Microarray analysis of gene expression on herbal glycoside recipes improving deficient ability of spatial learning memory in ischemic mice

Zhong, Wang; Du, Qingyou; Wang, Fusheng; Liu, Zhongrong; Li, Baigang; Wang, An Min; Wang, Yongyan

doi:10.1046/j.1471-4159.2003.02258.x

Cited by 28 publications

(18 citation statements)

References 48 publications

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“…The compound acts via the following mechanisms: blockade of calcium channels, scavenging of free radicals and inhibition of NMDA receptors. Moreover, some herbal glycoside recipes have been demonstrated to affect nine genes related to spatial learning and memory, thereby alleviating ischemic damage [74] . Considering that multifactorial and progressive pathophysiological processes are involved in cerebral ischemia therefore suggests that drugs binding to multiple targets or that combinations of drugs that act on single targets may be more effective in curing ischemia and related cerebral injury.…”

Section: Discussionmentioning

confidence: 99%

Natural compounds from traditional medicinal herbs in the treatment of cerebral ischemia/reperfusion injury

et al. 2010

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More and more attention in the field of drug discovery has been focused on the neuroprotection of natural compounds from traditional medicinal herbs. Cerebral ischemia is a complex pathological process involving a series of mechanisms, and a framework for the development of neuroprotectants from traditional herb medicine is a promising treatment for cerebral ischemia. Natural compounds with the effects of anti-oxidation, anti-inflammation, calcium antagonization, anti-apoptosis, and neurofunctional regulation exhibit preventive or therapeutic effects on experimental ischemic brain injury. According to the pharmacological mechanisms underlying neuroprotection, we evaluated natural products from traditional medicinal herbs that exhibit protective effects on ischemic brain injury and characterized the promising targets.

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Section: Discussionmentioning

confidence: 99%

Natural compounds from traditional medicinal herbs in the treatment of cerebral ischemia/reperfusion injury

et al. 2010

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“…[15][16][17][18] Recently, the global view of gene-expression profiles in the hippocampus has provided insight into the mechanisms and nature of the molecular changes underlying the effects of some herbal medicines on memory enhancement measured by behavior tests such as the passive avoidance test. 13,19,20) To evaluate the effect and mechanism of YMJd on memory enhancement, the passive avoidance test, cDNA microarray assays and Real Time PCR were performed.…”

Section: Fig 3 Number Of Significant Genes In Control and Ymjd Treamentioning

confidence: 99%

Effects of Yukmijihwang-tang Derivatives (YMJd), a Memory Enhancing Herbal Extract, on the Gene-Expression Profile in the Rat Hippocampus

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Kang

Choi

et al. 2005

Biological & Pharmaceutical Bulletin

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Memory may be conceptualized into three phases of information manipulation: those processes that handle the encoding of, storage of, and drawing upon learned and witnessed facts and events, which for humans is encoded physiologically. Two general forms of memory have been classified according to their duration in time: short-term memory (STM), which is rapidly formed and can outlast training from minutes to hours, and long-term memory (LTM), which lasts from hours to days, weeks, or even years.2) The hippocampus is a brain structure that plays a critical role in learning and memory in humans and animals.3) There have been many trials to find memory enhancing or cognition enhancing agents to ameliorate dementia. 8) Other studies report that YMJ increases neurogenesis in the dentate gyrus of the hippocampus in stressed rats 9) while enhancing memory retention and cognitive activities related to memory processes. 7,8) It is also reported that YMJ reverses scopolamine-induced and p-chloroamphetamine-induced amnesia in rats. 7) In addition, our unpublished data shows that YMJ derivatives (YMJd), including Lycii fructus, enhance memory retention by protecting neuronal cells from attack by reactive oxygen species (data not shown). In our recent study, K-WAIS, the Korean version of the WAIS test, and Event-Related Potential P300 latency during auditory oddball tasks were measured to assess the effect of YMJd on cognitive abilities in normal human subjects before and after 6 weeks of YMJd treatment. We found that the K-WAIS mean scores of the group treated with YMJd were significantly higher than those of the placebo group (pϽ0.05), while their mean P300 latency was substantially shorter (pϽ0.005). These results suggest that YMJd treatment accelerates the speed of information processing and enhances cognitive ability. 10) Thus, those results suggest that YMJ and its derivatives may be useful agents for the enhancement of learning and memory. However, there have been few reported studies on accessing the mechanism of memory enhancement triggered by treatment with YMJ or YMJd. The present study is designed to evaluate the action and mechanism behind the memory-enhancing effect of the herbal extract YMJd. Our results revealed that YMJd has a significant effect on memory enhancement and the expression of genes associated not only with the prevention of neuronal degeneration but also with neuronal growth events. The herbal extract Yukmijihwang-tang (YMJ) has been widely used for centuries as an anti-aging herbal medicine in Asian countries. Among the various modified prescriptions of YMJ, YMJ derivatives (YMJd) were formulated to enhance memory retention. This study has three goals: 1) to quantitatively evaluate the memoryenhancing effect of YMJd using behavior tasks; 2) to use cDNA micro-array tools to identify candidate genes responsible for enhancing memory; and 3) to statistically evaluate the specific gene expression patterns using Real-time PCR. Memory retention abilities are addressed by the passive avoidance task with...

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“…Functional annotation of these genes identified proteins with a role in neurotransmission, cell growth and neuroprotection. Another study involving brain function was designed by Wang et al [131]. In this work, cerebral ischemia was induced in mice that had been maintained on various dosages of a standardized TCM herbal glycoside recipe, consisting of the compounds baicalein and dioscin (see Fig.…”

Section: Systems Toxicologymentioning

confidence: 99%

Toxic plants: a chemist’s perspective

Hanson

2010

Experientia Supplementum

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Abstract. Chemistry has long been an integral part of toxicology, as the two fields originated in much the same way: the investigation of plants with interesting properties. In this chapter I review the role that chemistry has played in understanding toxic and medicinal plants. After some introductory remarks, three broad areas are addressed: the role of natural products in understanding plant taxonomy and evolution, recent developments in chemical synthesis, especially efforts to discover and efficiently synthesize novel structures based upon naturally occurring toxins, and finally, developments in the new field of systems toxicology, which seeks to integrate all aspects of an organism's response to toxic insult.

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Microarray analysis of gene expression on herbal glycoside recipes improving deficient ability of spatial learning memory in ischemic mice

Cited by 28 publications

References 48 publications

Natural compounds from traditional medicinal herbs in the treatment of cerebral ischemia/reperfusion injury

Natural compounds from traditional medicinal herbs in the treatment of cerebral ischemia/reperfusion injury

Effects of Yukmijihwang-tang Derivatives (YMJd), a Memory Enhancing Herbal Extract, on the Gene-Expression Profile in the Rat Hippocampus

Toxic plants: a chemist’s perspective

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