Microarray Analysis and Organization of Circadian Gene Expression in Drosophila

McDonald, Michael J.; Rosbash, Michael

doi:10.1016/s0092-8674(01)00545-1

Cited by 553 publications

(532 citation statements)

References 74 publications

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“…In previous studies it was suggested that the circadian system is involved in maintaining ROS homeostasis (Krishnan et al 2008). The rhythmic expression of genes involved in various metabolic pathways and stress resistance was reported in flies (Ceriani et al, 2001;McDonald and Rosbash, 2001) and in mammals (Miller et al, 2007). Daily rhythms have been supposed in the expression of some antioxidants such as catalase, SOD or GST.…”

Section: Discussionmentioning

confidence: 96%

Circadian rhythms of redox states and total locomotor activity in dairy cattle

Giannetto¹,

Fazio²,

Assenza³

et al. 2010

Czech J. Anim. Sci.

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ABSTRACT:We want to study the circadian rhythm of dROMs and anti-oxidative power in dairy cattle during dry period and the possible involvement of the circadian organization of rest/activity cycles in the fluctuation of redox state. For this purpose we recorded TLA in five clinically healthy Bruna Italian dairy cattle by means of an actigraphy-based data logger, Actiwatch-Mini ® . Blood samples were collected every 3 hours over a 48-hour period for the assessment of free radicals (dROMs) and the antioxidant power: antioxidant barrier (Oxy-ads) and thiol-antioxidant barrier (SHp). All animals were in the same productive period (dry) and they were housed in the same stable under natural photoperiod and ambient temperature. One-way repeated measure ANOVA was used to determine a statistical significant effect of time on the studied parameters. A trigonometric statistical model was applied to characterize the main rhythmic parameters according to the single cosinor procedure. A significant effect of time on all studied parameters was observed. They showed a diurnal acrophase and different degrees of robustness of rhythms. In conclusion, we can claim that there is a synergism between the dROM circadian rhythm and the circadian rhythm of anti-oxidative power. These rhythms do not have any implication for the issue of causation with the TLA circadian rhythms.

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Section: Discussionmentioning

confidence: 96%

Circadian rhythms of redox states and total locomotor activity in dairy cattle

Giannetto¹,

Fazio²,

Assenza³

et al. 2010

Czech J. Anim. Sci.

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“…Borycz et al (2002) have found that histamine levels are low in both ebony and black and both are deficient in carcinine. Studies by others (McDonald and Rosbash, 2001;Richardt et al, 2003) show that while black mRNA cycles in response to light/dark cues, as does histidine decarboxylase (hdc) and ebony, the black message peaks some 6 -7 h earlier than the other messages i.e. black is most highly expressed in the night and hdc and ebony at dawn.…”

Section: Discussionmentioning

confidence: 99%

The Drosophila black enigma: The molecular and behavioural characterization of the black1 mutant allele

Phillips

Smart

Strauß³

et al. 2005

Gene

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The cuticular melanization phenotype of black flies is rescued by h-alanine, but h-alanine production, by aspartate decarboxylation, was reported to be normal in assays of black mutants, and although black/Dgad2 is expressed in the lamina, the first optic ganglion, no electroretinogram (ERG) or other visual defect has been demonstrated in black flies. The purpose of this study was to investigate the black gene, and protein, in black 1 mutants of Drosophila melanogaster in order to resolve the apparent paradox of the black phenotype. Using black 1 mutant flies we show that (1) aspartate decarboxylase activity is significantly reduced in adults and at puparium formation, consistent with defects in cuticular and non-cuticular processes, (2) that the black 1 mutation is a frameshift, and black 1 flies are nulls for the black/ DGAD2 protein, and (3) that behavioural experiments using Buridan's paradigm, demonstrate that black responds abnormally to visual cues. No ERG, or target recognition defects can be demonstrated suggesting a problem with higher order visual functions in black mutants. D

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“…Although the function of "clock" genes in generating circadian rhythms is now firmly established, their implication in other molecular pathways is likely given their wide-spread expression throughout the organism and the large number and diversity of genes controlling fundamental biologic processes that are under the influence of "clock" genes in Arabidopsis, Drosophila, and the mouse (Harmer et al, 2000;Claridge-Chang et al, 2001;McDonald and Rosbash, 2001;Rutter et al, 2001;Panda et al, 2002a;Storch et al, 2002;Ueda et al, 2002). The distinct roles of circadian and homeostatic components in sleep regulation are often difficult to discern (Dijk and Czeisler, 1994).…”

Section: Conclusion Sleep Homeostasis As An Oscillatory Network Of Trmentioning

confidence: 99%

Perchance to dream: Solving the mystery of sleep through genetic analysis

Shaw

Franken

2002

J. Neurobiol.

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Sleep has been identified in all mammals and nonmammalian vertebrates that have been critically evaluated. In addition, sleep-like states have also been identified and described in several invertebrates. Despite this prevalence throughout the animal kingdom, the function of sleep remains a mystery. The completion of several genome sequencing projects has led to the expectation that fundamental aspects of sleep can be elucidated through genetic dissection. Indeed, studies in both the mouse and fly have begun to reveal tantalizing suggestions about the underlying principles that regulate sleep homeostasis. In this article we will review recent studies that have used genetic techniques to evaluate sleep in the fruit fly and the mouse.

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Microarray Analysis and Organization of Circadian Gene Expression in Drosophila

Cited by 553 publications

References 74 publications

Circadian rhythms of redox states and total locomotor activity in dairy cattle

Circadian rhythms of redox states and total locomotor activity in dairy cattle

The Drosophila black enigma: The molecular and behavioural characterization of the black1 mutant allele

Perchance to dream: Solving the mystery of sleep through genetic analysis

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