Microarchitecture of the Vitreous Body: A High-Resolution Optical Coherence Tomography Study

Uji, Akihito; Yoshimura, Nagahisa

doi:10.1016/j.ajo.2016.04.021

Cited by 16 publications

(11 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Over 80% of the structure of the eyeball is natural vitreous body, which contains only 1% of proteins, hyaluronan, lipids and inorganic chemical compounds. Natural vitreous body, which was proved to maintain a certain spatial relationship with dipolar water molecules, has the ability to support the retina, supply nutrition, stabilize intraocular metabolism, act as cell barrier and ocular refractive media, etc [1] However, the composition of natural vitreous body is unclear, which means it is impossible to create artificial vitreous body [2][3][4]. Furthermore, due to the natural vitreous body is non-renewable [5][6][7], vitrectomy and SO tamponade are required when vitreoretinal diseases occur, such as retinal detachment caused by severe ocular trauma, post-trauma proliferative vitreoretinopathy, proliferative diabetic retinopathy and endophthalmitis [8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Study on the effectiveness and safety of Foldable Capsular Vitreous Body implantation

Zhang

Tian²,

Zhang³

et al. 2019

BMC Ophthalmol

View full text Add to dashboard Cite

Background: Foldable capsular vitreous body (FCVB) was designed to treat severe retinal detachment. The aim of this study was to evaluate the efficacy and safety of the implantation of foldable capsular vitreous body in 1-year follow-up. Methods: A retrospective analysis was conducted for 20 patients with severe ocular trauma or silicone oil (SO) dependent eyes underwent vitrectomy and FCVB implantation in a 1-year follow-up. All treated eyes were peformed clinical examinations involved the visual acuity (VA) examination, Goldmann applanation tonometer, noncontact specular microscopy, fundus photography, B-Scan examination and optical coherence tomography (OCT). The groups were compared with t-test and the McNemar-Bowker test. Results: In 1-year follow-up, 20 eyes were evaluated in the study. FCVB well supported the vitreous retina in all treated eyes, and 6 treated eyes achieved retinal reattachment 12 months after FCVB implantation. There were no significant differences in VA before and after FCVB implantation (P = 1.000). In addition, the postoperative IOP markedly elevated from the preoperative IOP of 12.90 ± 7.06 mmHg to 15.15 ± 3.36 mmHg (P = 0.000017). The intraocular pressure (IOP) of 10 eyes maintained at a normal level after surgeries. The other 10 eyes showed slightly lower IOP within the acceptable level. Though two patients developed keratopathy and ocular inflammation respectively, other treated eyes were symmetric with fellow eyes showing satisfactory appearance. Moreover, there was no SO emulsification or leakage happened in the observation. Conclusions: FCVB implantation was an effective and safe treatment in the eyes with severe retinal detachment.

show abstract

Section: Introductionmentioning

confidence: 99%

Study on the effectiveness and safety of Foldable Capsular Vitreous Body implantation

Zhang

Tian²,

Zhang³

et al. 2019

BMC Ophthalmol

View full text Add to dashboard Cite

show abstract

“…An OCTA system (OCT-HS100; Canon, Tokyo, Japan) with an optical axial resolution of 3 lm is now commercially available. 7 The OCT-HS100 can generate high-contrast OCTA with a multiple en face averaging technique. In this study, we used the OCT-HS100 to differentiate the four layers of retinal capillary plexuses in the living human macula and investigated angiographic features of each plexus and relationships between the plexuses.…”

mentioning

confidence: 99%

Segmentation of the Four-Layered Retinal Vasculature Using High-Resolution Optical Coherence Tomography Angiography Reveals the Microcirculation Unit

Muraoka

Uji

Ishikura

et al. 2018

Invest. Ophthalmol. Vis. Sci.

Self Cite

View full text Add to dashboard Cite

Citation: Muraoka Y, Uji A, Ishikura M, Iida Y, Ooto S, Tsujikawa A. Segmentation of the four-layered retinal vasculature using high-resolution optical coherence tomography angiography reveals the microcirculation unit. Invest Ophthalmol Vis Sci. 2018;59:5847-5853. https://doi.org/ 10.1167/iovs.18-25301 PURPOSE. To differentiate the four layers of the retinal vessel network in the human macula and examine their morphologic features using high-resolution optical coherence tomography angiography (HR-OCTA).METHODS. Macular areas measuring 464 3 464 pixels of 10 right eyes of 10 healthy subjects without ocular disease were scanned 10 times using a HR-OCTA device. Averaged OCTA images were created. Based on clear decorrelation signals, four vascular slabs were segmented, comprising one each in the retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), and top and bottom of the inner nuclear layer (INL). Qualitative features and quantitative measurements in each slab were compared with those in conventionally segmented slabs.RESULTS. HR-OCTA isolated four layers of vascular plexuses in the macula that followed the corresponding anatomic layers. Segmentations for the RNFL revealed that radial peripapillary capillaries (RPCs) extended to the central macular area. The RPCs followed relatively straight and long paths, with few apparent feed points and anastomoses. The GCL slab enhanced visualization of the capillary-free zones around the arteries and arterioles and helped to differentiate arterial and venous systems. The arterioles and venules were linked by capillaries that were arranged in a mesh-like fashion, with multiple arteriolar feed points and anastomoses. Vascular plexuses in the top and bottom of the INL consisted of capillaries in a vortex arrangement. The center of these vortex arrangements was consistent with the venules in the GCL.CONCLUSIONS. HR-OCTA can differentiate the four layers of vascular plexuses in the human macula and elucidate their angiographic features.

show abstract

“…Koo et al [25] described the passage of intravitreal nanoparticles through the retina by both diffusion and endocytosis by the Müller cells, and Xu et al [26] found that cationic amphiphilic intravitreal polymers reached RPE cells. The space between the ILM and the PVC houses an interdigitate extracellular matrix [15]. In this space, the authors observed that the BRI/LAP IF arranged itself in a row with the aggregates ordered one after the other at different heights, concentrically (see Fig.…”

Section: Discussionmentioning

confidence: 99%

Monitoring New Long-Lasting Intravitreal Formulation for Glaucoma with Vitreous Images Using Optical Coherence Tomography

Rodrigo

Palomar

Montolío

et al. 2020

Preprint

View full text Add to dashboard Cite

Intravitreal injection is the gold standard therapeutic option for posterior segment pathologies, and long-lasting release is necessary to avoid reinjections. There is no effective intravitreal treatment for glaucoma or other optic neuropathies in daily practice, nor is there a non-invasive method to monitor drug levels in the vitreous. Here we show that a glaucoma treatment combining a hypotensive and neuroprotective intravitreal formulation (IF) of brimonidine-Laponite (BRI/LAP) can be monitored non-invasively using vitreous imaging captured with optical coherence tomography (OCT) over 24 weeks of follow-up. Qualitative and quantitative characterization was achieved by analysing the changes in vitreous (VIT) signal intensity, expressed as a ratio of retinal pigment epithelium (RPE) intensity. Vitreous hyperreflective aggregates mixed in the vitreous and tended to settle on the retinal surface. Relative intensity and aggregate size progressively decreased over 24 weeks in treated rat eyes as the BRI/LAP IF degraded. VIT/RPE relative intensity and total aggregate area correlated with brimonidine levels measured in the eye. The OCT-derived VIT/RPE relative intensity may be a useful and objective marker for non-invasive monitoring of BRI/LAP IF.

show abstract

Microarchitecture of the Vitreous Body: A High-Resolution Optical Coherence Tomography Study

Cited by 16 publications

References 24 publications

Study on the effectiveness and safety of Foldable Capsular Vitreous Body implantation

Study on the effectiveness and safety of Foldable Capsular Vitreous Body implantation

Segmentation of the Four-Layered Retinal Vasculature Using High-Resolution Optical Coherence Tomography Angiography Reveals the Microcirculation Unit

Monitoring New Long-Lasting Intravitreal Formulation for Glaucoma with Vitreous Images Using Optical Coherence Tomography

Contact Info

Product

Resources

About