Microarchitectural adaptations in aging and osteoarthrotic subchondral bone issues

Ding, Ming

doi:10.3109/17453671003619037

Cited by 48 publications

(41 citation statements)

References 193 publications

(298 reference statements)

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“…Each 3D image dataset consisted of approximately 210 μCT slide images of which 100 slide images (1250μm) were used for analysis of bone tissue (2048 × 2048 pixels) with 16-bit grey levels. Bone volume fraction (BV/TV), bone surface to bone volume ratio (BS/BV), and trabecular separation (TbSp) were calculated based on assumption-free 3D methods 80 .…”

Section: Methodsmentioning

confidence: 99%

The Src family kinase inhibitor dasatinib delays pain-related behaviour and conserves bone in a rat model of cancer-induced bone pain

Appel

Gallego-Pedersen

Andersen

et al. 2017

Sci Rep

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Pain is a severe and debilitating complication of metastatic bone cancer. Current analgesics do not provide sufficient pain relief for all patients, creating a great need for new treatment options. The Src kinase, a non-receptor protein tyrosine kinase, is implicated in processes involved in cancer-induced bone pain, including cancer growth, osteoclastic bone degradation and nociceptive signalling. Here we investigate the role of dasatinib, an oral Src kinase family and Bcr-Abl tyrosine kinase inhibitor, in an animal model of cancer-induced bone pain. Daily administration of dasatinib (15 mg/kg, p.o.) from day 7 after inoculation of MRMT-1 mammary carcinoma cells significantly attenuated movement-evoked and non-evoked pain behaviour in cancer-bearing rats. Radiographic - and microcomputed tomographic analyses showed significantly higher relative bone density and considerably preserved bone micro-architecture in the dasatinib treated groups, suggesting a bone-preserving effect. This was supported by a significant reduction of serum TRACP 5b levels in cancer-bearing rats treated with 15 mg/kg dasatinib. Furthermore, immunoblotting of lumbar spinal segments showed an increased activation of Src but not the NMDA receptor subunit 2B. These findings support a role of dasatinib as a disease modifying drug in pain pathologies characterized by increased osteoclast activity, such as bone metastases.

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Section: Methodsmentioning

confidence: 99%

The Src family kinase inhibitor dasatinib delays pain-related behaviour and conserves bone in a rat model of cancer-induced bone pain

Appel

Gallego-Pedersen

Andersen

et al. 2017

Sci Rep

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“…In the late stage of OA, microarchitectural characteristics of subchondral bone are elevated apparent density, increased bone volume, thickening of subchondral bone plate, increased trabecular thickness, decrease of trabecular separation and bone marrow spacing, and transformation of trabeculae from rod-like into plate-like [94]. The overlying calcified cartilage is also thickened, with advancement and duplication of the tidemark (Figure 2), which contributes to articular cartilage thinning and deterioration [20].…”

Section: Microarchitectural Changes Of Subchondral Bone In Osteoarthrmentioning

confidence: 99%

Subchondral bone in osteoarthritis: insight into risk factors and microstructural changes

et al. 2013

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Osteoarthritis (OA) is a major cause of disability in the adult population. As a progressive degenerative joint disorder, OA is characterized by cartilage damage, changes in the subchondral bone, osteophyte formation, muscle weakness, and inflammation of the synovium tissue and tendon. Although OA has long been viewed as a primary disorder of articular cartilage, subchondral bone is attracting increasing attention. It is commonly reported to play a vital role in the pathogenesis of OA. Subchondral bone sclerosis, together with progressive cartilage degradation, is widely considered as a hallmark of OA. Despite the increase in bone volume fraction, subchondral bone is hypomineralized, due to abnormal bone remodeling. Some histopathological changes in the subchondral bone have also been detected, including microdamage, bone marrow edema-like lesions and bone cysts. This review summarizes basic features of the osteochondral junction, which comprises subchondral bone and articular cartilage. Importantly, we discuss risk factors influencing subchondral bone integrity. We also focus on the microarchitectural and histopathological changes of subchondral bone in OA, and provide an overview of their potential contribution to the progression of OA. A hypothetical model for the pathogenesis of OA is proposed.

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“…In our study, Fe in the severe OA group (subchondral and ilium bone) was higher than that in the normal group by 60.4 times, which could be caused by subchondral bone sclerosis and osteophyte formation with increasing collagen synthesis. In severe OA, subchondral bone is characterized by an elevated apparent density, increased bone volume, and thickening of the subchondral bone plate [26]. Even with an increased bone volume density, the mineralization was reduced and lower than normal.…”

Section: Discussionmentioning

confidence: 96%

“…*p < 0.05 indicates a significant difference ratio of Ca/P. In 2006, Akesson et al [26] compared some elements (Se, Cu, Zn, and Fe) in synovial fluid and plasma between normal patients and those with rheumatoid arthritis (RA) or OA. Only synovial fluid Cu and Fe concentration were significantly higher in the OA group.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Bone Tissue Elements Between Normal and Osteoarthritic Pelvic Bones in Dogs

Nganvongpanit

Buddhachat

Brown

2015

Biol Trace Elem Res

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Physiochemical analysis of bones affected with osteoarthritis (OA) can be used to better understand the etiology of this disease. We investigated the percentage of chemical elements in canine pelvic bone affected with varying degrees of OA using a handheld X-ray fluorescence (XRF) analyzer that discriminates magnesium (Mg(12)) through bismuth (Bi(83)). A total of 45 pelvic bones, including both ilium and subchondral acetabular bone plates, were categorized as normal (n = 20), mild grade OA (n = 5), moderate grade OA (n = 15), and severe grade OA (n = 5). In normal pelvic, seven elements (P, Ca, Mn, Ag, Cd, Sn, and Sb) differed (p < 0.005) in percentage between ilium and acetabulum. Comparisons among the four OA groups found Mn and Fe to be highest in severe grades (p < 0.05) in both ilium and acetabulum. Three heavy metals (Ag, Sn, and Sb) were detected in high percentages (p < 0.05) in the severe OA group in the acetabulum, but in ilium only Sn was high (p < 0.05) in severe OA. In conclusion, the percentages of several elements differed between pelvic types in dogs, and also with increasing severity of OA. The finding of high Mn and Fe in severe grade OA bone suggests these two elements may be useful in future studies of the etiology and pathophysiology of OA.

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Microarchitectural adaptations in aging and osteoarthrotic subchondral bone issues

Cited by 48 publications

References 193 publications

The Src family kinase inhibitor dasatinib delays pain-related behaviour and conserves bone in a rat model of cancer-induced bone pain

The Src family kinase inhibitor dasatinib delays pain-related behaviour and conserves bone in a rat model of cancer-induced bone pain

Subchondral bone in osteoarthritis: insight into risk factors and microstructural changes

Comparison of Bone Tissue Elements Between Normal and Osteoarthritic Pelvic Bones in Dogs

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