Microanatomical effects of ethanolic extract of <i>Cola nitida</i> on the stomach mucosa of adult wistar rats

Abstract

The study investigated the microanatomical effects of the extracts of Cola nitida on the stomach mucosa of adult male Wistar rats. Twenty adult male wistar rats were randomly divided into four equal groups of A, B, C and D (n=5). Animals in experimental groups B, C and D were given 600mg/kg body weight of crude extract of Cola nitida each by oral intubation for five, seven and nine consecutive days respectively, while group A (control) received equivalent volume of distilled water. Twenty four hrs after the last administration, the animals were sacrificed; tissues were harvested and fixed in 10% formol saline for histological analysis. The study revealed necrotized surface epithelium, degenerated gastric mucosa, and loss of glandular elements in the stomachs of experimental groups' vis-à-vis the control group. These observations were days-dependent; as those groups which received the extract for higher number of days were seen to be adversely affected. In conclusion, Cola nitida at 600mg/kg body weight can cause gastric lesion in animals. This lesion may be pronounced if the administration continued for days. Cola nitida should, therefore, be taken with caution to avoid gastric complications.

The Therapeutic Potential of Cola nitida in Health and Disease: A Review

“…Lawal et al, 2022;Osim et al, 1991;Tende et al, 2011;Umoh et al, 2019). Moreover, high doses of Cola nitida have been observed to induce gastric lesions in animals, and these lesions can worsen with prolonged administration (Ojo et al, 2010). It is advised to consume Cola nitida with caution to minimize the risk of gastric complications, particularly for individuals with ulcers who may consider avoiding it.…”

“…May have gastroprotective effects, but may also stimulate gastric secretion and erode mucosa epithelial lining (Ibu et al, 1986;A. Lawal et al, 2022;Ojo et al, 2010;Osim et al, 1991;Tende et al, 2011;Umoh et al, 2019). 5…”

Dynamic changes in the hippocampal memory index and biochemical indices in Sprague Dawley rats exposed to intrauterine kola nut

“…Traditionally, fresh seeds are used in the treatment of many ailments, including infections, toothaches, morning sickness, skin diseases, and ulcers (Tachie- Obeng and Brown, 2004). It is also known as a stimulant and appetite suppressant (Ojo et al, 2010). Fresh nuts are used in the commercial production of beverages, especially cola drinks, wines, and chocolates (Ogutuga, 1975;Dah-Nouvlessounon et al, 2015).…”

Temporal Evolution of Organochlorine Pesticides Residues in Kola Nuts (Cola nitida Vent Nuts. Schott & Endl.) Processing in Eastern of Côte d’Ivoire

“…In addition, the kola nuts play an important social role in African societies where it symbolizes the sacred. Indeed, it is used in socio-cultural rites such as weddings, baptisms, manifestations of friendships, funerals, rituals and sacrifices [9,10,11]. The kolanut is also used as a stimulant, promoting the physical and psychic endurance of manual workers [12,13].…”