Microalgal Oil Supplementation Has an Anti-Obesity Effect in C57BL/6J Mice Fed a High Fat Diet

Yook, Jin Seon; Kim, Kyung-Ah; Park, Jeong Eun; Lee, Seon Hwa; Soo, Youn

doi:10.3746/pnf.2015.20.4.230

Cited by 19 publications

(11 citation statements)

References 42 publications

(45 reference statements)

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“…In the present study, HF diet induced hyperleptinemia, while supplementation with P. tricornutum decreased the leptin level. This is consistent with the results of Yook et al, who showed a significant decrease in leptin plasma concentration, after eight weeks of treatment, in C57BL/6J mice fed a HF diet supplemented with Aurantiochytrium microalgal oil as a source of n-3 LC-PUFA [74]. Thus, n-3 LC-PUFA could be a potential agent against hyperleptinemia.…”

Section: Discussionsupporting

confidence: 91%

Preventive Effects of the Marine Microalga Phaeodactylum tricornutum, Used as a Food Supplement, on Risk Factors Associated with Metabolic Syndrome in Wistar Rats

et al. 2019

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Long-chain polyunsaturated fatty acids, n-3 series (n-3 LC-PUFA), are known for their preventive effects against cardiovascular disease. In an unfavourable economic and environmental context of fish oil production, marine microalgae could be an alternative source of n-3 LC-PUFA and are of interest for human nutrition. The aim of this study was to evaluate the effects of P. tricornutum, a microalga rich in eicosapentaenoic acid and used as a food supplement, on the metabolic disorders associated with metabolic syndrome and obesity development. Three male Wistar rat groups (n = 6) were submitted for eight weeks to a standard diet or high-fat diet (HF) with 10% fructose in drinking water, supplemented or not with 12% of P. tricornutum (HF-Phaeo). Supplementation led to n-3 LC-PUFA enrichment of lipids in the liver, plasma and erythrocytes. Plasma transaminases showed no difference between the HF and HF-Phaeo groups. Body weight, fat mass, inflammatory markers and insulinemia decreased in HF-Phaeo rats versus the HF group. Plasma total cholesterol, triacylglycerols and leptine diminished in HF-Phaeo rats, while HDL-cholesterol increased. In conclusion, this study highlights the beneficial effects of P. tricornutum in reducing the metabolic disorders associated with metabolic syndrome.

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Section: Discussionsupporting

confidence: 91%

Preventive Effects of the Marine Microalga Phaeodactylum tricornutum, Used as a Food Supplement, on Risk Factors Associated with Metabolic Syndrome in Wistar Rats

et al. 2019

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“…At the end of week 10, insulin level of rats fed HFFD were higher than normal control. This result was the same as some researches, who stated that insulin concentrations were higher in the rats fed high fat diet compared to control [34][35][36][37][38][39], although their results were slightly different. Le et al said that high fructose diet in offspring of type 2 diabetic patients increased fasting plasma concentration of insulin [40].…”

Section: Discussionsupporting

confidence: 89%

Anthocyanin Extract of Purple Corn Improves Hyperglycemia and Insulin Resistance of Rats Fed High Fat and Fructose Diet via GLP1 and GLP1R Mechanism

Chayati¹,

Sunarti²,

Marsono³

et al. 2019

JFNR

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Hyperglycemia and insulin resistance are caused by high fat, fructose, or fat and fructose diet. The aim of this study was to investigate the effect of anthocyanin extract of purple corn (AEPC) on insulin resistance of rats fed high fat and fructose diet (HFFD). Insulin resistance was induced by feeding HFFD for 4 weeks and Wistar male rats were orally supplemented with the following treatments for the next six weeks: pioglitazone 1.35 mg kg-1 body weight (bw) as a positive control group (PC), AEPC 6 mg kg-1 bw (LA), AEPC 12.5 mg kg-1 bw (MA), and AEPC 25 mg kg-1 bw (HA), or no treatment as a negative control group (NC). A normal control group was fed a normal diet (NLC) for along 10 weeks. Insulin resistance was indicated by Homeostasis Model Assessments for Insulin Resistance (HOMA-IR) scores. The results showed that HFFD feeding increased HOMA-IR score and blood glucose levels, and decreased levels of plasma glucagon-like peptide 1 (GLP1) and pancreatic glucagon-like peptide 1 receptor (GLP1R). Administration of AEPC reduced HOMA-IR scores and blood glucose levels, increased HOMA-β and HOMA-IS scores, plasma GLP1 and pancreatic GLP1R levels, and improved pancreatic morphology. Our finding suggests that AEPC 12.5 mg kg-1 bw gave the best conditions to improve insulin resistance as well as standard drug administration pioglitazone 1.35 mg kg-1 bw via GLP1 and GLP1R mechanism.

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“…T. lutea supplementation, rich in DHA, restored plasma leptin level in HF-fed Wistar rats. The study conducted by Yook et al [ 76 ] showed a leptinemia decrease after eight weeks of treatment in HF-fed C57BL/6 J mice supplemented with Aurantiochytrium microalga oil rich in DHA.…”

Section: Discussionmentioning

confidence: 99%

“…As well as other microalga species, T. lutea could have an anti-diabetic activity due to its high levels of bioactive molecules such as DHA and fucoxanthin [ 17 , 53 , 78 , 79 , 80 ]. Thus, the study of Yook et al [ 76 ] showed preventive effects of Aurantiochytrium sp. microalga oil (rich in n-3 PUFA, DHA) against hyperinsulinemia in C57BL/6 J mice submitted to a hyperlipidic diet, suggesting the beneficial effects of n-3 LC-PUFA, and particularly DHA, in the improvement of insulin sensitivity.…”

Section: Discussionmentioning

confidence: 99%

The Marine Microalga, Tisochrysis lutea, Protects against Metabolic Disorders Associated with Metabolic Syndrome and Obesity

et al. 2021

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Long-chain polyunsaturated fatty acids n-3 series and especially docosahexaenoic acid are known to exert preventive effects on metabolic disturbances associated with obesity and decrease cardiovascular disease risk. n-3 LC-PUFAs are mainly consumed in the form of fish oil, while other sources, such as certain microalgae, may contain a high content of these fatty acids. The aim of this study was to evaluate the effects of Tisochrysis lutea (Tiso), a microalga rich in DHA, on metabolic disorders associated with obesity. Three male Wistar rat groups were submitted for eight weeks to a standard diet or high-fat and high fructose diet (HF), supplemented or not with 12% of T. lutea (HF-Tiso). The supplementation did not affect plasma alanine aminotransferase (ALAT). Bodyweight, glycemia and insulinemia decreased in HF-Tiso rats (ANOVA, p < 0.001), while total plasma cholesterol, high-density lipoprotein-cholesterol (HDL-C) increased (ANOVA, p < 0.001) without change of low-density lipoprotein-cholesterol (LDL-C) and triacylglycerol (TAG) levels. Tiso supplementation decreased fat mass and leptinemia as well as liver TAG, cholesterol and plasma tumor necrosis factor-alpha levels (ANOVA, p < 0.001) while it did not affect interleukin 6 (IL-6), IL-4 and lipopolysaccharides levels. HF-Tiso rats showed an increase of IL-10 level in abdominal adipose tissue (ANOVA, p < 0.001). In conclusion, these results indicated that DHA-rich T. lutea might be beneficial for the prevention of obesity and improvement of lipid and glucose metabolism.

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Microalgal Oil Supplementation Has an Anti-Obesity Effect in C57BL/6J Mice Fed a High Fat Diet

Cited by 19 publications

References 42 publications

Preventive Effects of the Marine Microalga Phaeodactylum tricornutum, Used as a Food Supplement, on Risk Factors Associated with Metabolic Syndrome in Wistar Rats

Preventive Effects of the Marine Microalga Phaeodactylum tricornutum, Used as a Food Supplement, on Risk Factors Associated with Metabolic Syndrome in Wistar Rats

Anthocyanin Extract of Purple Corn Improves Hyperglycemia and Insulin Resistance of Rats Fed High Fat and Fructose Diet via GLP1 and GLP1R Mechanism

The Marine Microalga, Tisochrysis lutea, Protects against Metabolic Disorders Associated with Metabolic Syndrome and Obesity

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