Microalgae pigments as a promising immunomodulating food ingredient: In silico study

Widyaningrum, Dwiyantari; Oktafika, R A; Cecilia, Diana

doi:10.1088/1755-1315/998/1/012056

Cited by 6 publications

(5 citation statements)

References 37 publications

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“…These approaches can help in speeding up the discovery of natural products with different potential bioactivities within different genera by identifying clusters of genes that are responsible for their synthesis [ 3 ]. An example of an in silico study has been recently published in 2022 by Widyaningrum [ 56 ], whose purpose was to study the immunomodulatory activity of microalgal pigments and propose a first clue in regard to the mechanism of microalgal pigments that modulate the human immune system. Overall, this review shows that marine organisms can produce bioactive molecules to stimulate the immune system and are worthy of further investigation.…”

Section: Discussionmentioning

confidence: 99%

“…A 2022 in silico study that used molecular docking [ 56 ] showed that microalgae pigments β-carotene, phycocyanobilin, astaxantin, 9-cis-β-carotene, and violaxantin docked pro-inflammatory proteins such as TNFα, IL-6, and NF-κB-inducing kinase (NIK). The aims of the researchers were (1) to investigate the immunomodulating activity of microalgal pigments and (2) to propose a first clue on the mechanism of microalgal pigments modulating the human immune system.…”

Section: Marine Microorganisms As Source Of Immunomodulatory Compoundsmentioning

confidence: 99%

“…The exploration of natural compounds that are able to inhibit NIK can lead to the discovery of compounds that are capable of inhibiting the NF-kB pathway and modulating the immune system [ 61 ]. Similar to this, microalgae pigment may support the immune system modulation and prevent and attenuate chronic inflammatory [ 56 ].…”

Section: Marine Microorganisms As Source Of Immunomodulatory Compoundsmentioning

confidence: 99%

See 2 more Smart Citations

Recent Discoveries on Marine Organism Immunomodulatory Activities

2022

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Marine organisms have been shown to be a valuable source for biologically active compounds for the prevention and treatment of cancer, inflammation, immune system diseases, and other pathologies. The advantage of studying organisms collected in the marine environment lies in their great biodiversity and in the variety of chemical structures of marine natural products. Various studies have focused on marine organism compounds with potential pharmaceutical applications, for instance, as immunomodulators, to treat cancer and immune-mediated diseases. Modulation of the immune system is defined as any change in the immune response that can result in the induction, expression, amplification, or inhibition of any phase of the immune response. Studies very often focus on the effects of marine-derived compounds on macrophages, as well as lymphocytes, by analyzing the release of mediators (cytokines) by using the immunological assay enzyme-linked immunosorbent assay (ELISA), Western blot, immunofluorescence, and real-time PCR. The main sources are fungi, bacteria, microalgae, macroalgae, sponges, mollusks, corals, and fishes. This review is focused on the marine-derived molecules discovered in the last three years as potential immunomodulatory drugs.

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Section: Discussionmentioning

confidence: 99%

Section: Marine Microorganisms As Source Of Immunomodulatory Compoundsmentioning

confidence: 99%

Section: Marine Microorganisms As Source Of Immunomodulatory Compoundsmentioning

confidence: 99%

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Recent Discoveries on Marine Organism Immunomodulatory Activities

2022

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“…Recently, various papers have reported docking tools, compared them and tested their efficacy in virtual screening against a wide range of protein targets [ 122 , 139 , 140 , 141 , 142 ]. Very recently, these in silico studies have begun to focus on marine organisms and marine natural products [ 143 ]. This approach requires low costs and offers the possibility of using an ecofriendly research strategy (no need to sample several species and induce damage to the environment).…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

In Silico Methodologies to Improve Antioxidants’ Characterization from Marine Organisms

et al. 2023

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Marine organisms have been reported to be valuable sources of bioactive molecules that have found applications in different industrial fields. From organism sampling to the identification and bioactivity characterization of a specific compound, different steps are necessary, which are time- and cost-consuming. Thanks to the advent of the -omic era, numerous genome, metagenome, transcriptome, metatranscriptome, proteome and microbiome data have been reported and deposited in public databases. These advancements have been fundamental for the development of in silico strategies for basic and applied research. In silico studies represent a convenient and efficient approach to the bioactivity prediction of known and newly identified marine molecules, reducing the time and costs of “wet-lab” experiments. This review focuses on in silico approaches applied to bioactive molecule discoveries from marine organisms. When available, validation studies reporting a bioactivity assay to confirm the presence of an antioxidant molecule or enzyme are reported, as well. Overall, this review suggests that in silico approaches can offer a valuable alternative to most expensive approaches and proposes them as a little explored field in which to invest.

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“…Molecular interaction prediction between several S. platensis bioactive compounds already perform to see the interaction of S. platensis bioactive compounds in inflammatory regulation involving NF-κB activation pathway, IL-6, TNF-α, and COX-2 [13,14]. This study aims to analyze the effect of S. platensis ethanol extract supplementation on IL-10 mRNA expression in the spleen of healthy rats in emerging adults and young adults.…”

Section: Introductionmentioning

confidence: 99%

Supplementation of Spirulina platensis ethanol extract: influence on mRNA expression and prediction of molecular interactions with IL-10

Purba,

Paramita,

Prijanti

et al. 2023

IOP Conf. Ser.: Earth Environ. Sci.

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Alleviation of inflammation requires an optimal balance between pro and anti-inflammatory cytokines, in which IL-10 plays a critical role as a major anti-inflammatory cytokine. Studies about the ability of the active component of Spirulina platensis to promote IL-10 expression still vary. This study aims to analyze the effect of S. platensis on IL-10 mRNA expression in healthy rats of emerging adults and young adults. This study used six groups of male Wistar rats aged 12, 18, and 24 weeks treated with 200 mg/kg BW of S. platensis extract and a control group. Molecular interaction was predicted between three bioactive compounds of S. platensis (α-glucan, β-carotene, phycocyanobilin) and tacrolimus (control ligand) with IL-10 protein. The relative expression ratio of IL-10 mRNA increased in the treatment rats at 12 weeks (1.77) and 24 weeks (2.05). In rats aged 18 weeks, there was no increase in the expression ratio of IL-10 mRNA in treated rats compared to controls (0.91). Tacrolimus, the control ligand, has the best affinity as an IL-10 inhibitor (-6.68 kcal/mol), followed by β-carotene (-5.83 kcal/mol). The ethanolic extract of S. platensis can potentially increase the expression of IL-10 mRNA in the rat spleen at 12 and 24 weeks.

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Microalgae pigments as a promising immunomodulating food ingredient: In silico study

Cited by 6 publications

References 37 publications

Recent Discoveries on Marine Organism Immunomodulatory Activities

Recent Discoveries on Marine Organism Immunomodulatory Activities

In Silico Methodologies to Improve Antioxidants’ Characterization from Marine Organisms

Supplementation of Spirulina platensis ethanol extract: influence on mRNA expression and prediction of molecular interactions with IL-10

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