Microalgae in modern cancer therapy: Current knowledge

El‐Hack, Mohamed E. Abd; Abdelnour, Sameh A.; Alagawany, Mahmoud; Abdo, Mohamed; Sakr, Moustafa A.; Khafaga, Asmaa F.; Mahgoub, Samir A.; Elnesr, Shaaban S.; Gebriel, Manar G

doi:10.1016/j.biopha.2018.12.069

Cited by 148 publications

(108 citation statements)

References 109 publications

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“…Indeed, the growing interest in the use of microalgae in human health comes from their composition that is rich in molecules of interest (lipids, polysaccharides, carotenoids) known to have beneficial effects on health [27]. In addition, many studies reveal the pharmacological interest of microalgae as natural products that can offer significant benefits in CVDs, inflammation, and cancer [68][69][70][71][72]. In this context, our study aimed at evaluating the capacity of two microalgal extracts from the green alga Ostreococcus tauri (OT) and the diatom Phaeodactylum tricornutum (PT), to prevent harmful effects induced by an environmental pollutant, B[a]P, known to contribute to the development or aggravation of human pathologies notably CVDs [2,3].…”

Section: Discussionmentioning

confidence: 99%

Protective Action of Ostreococcus Tauri and Phaeodactylum Tricornutum Extracts towards Benzo[a]Pyrene-Induced Cytotoxicity in Endothelial Cells

Goff

Delbrut²,

Quinton³

et al. 2019

Marine Drugs

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Marine microalgae are known to be a source of bioactive molecules of interest to human health, such as n-3 polyunsaturated fatty acids (n-3 PUFAs) and carotenoids. The fact that some of these natural compounds are known to exhibit anti-inflammatory, antioxidant, anti-proliferative, and apoptosis-inducing effects, demonstrates their potential use in preventing cancers and cardiovascular diseases (CVDs). Benzo[a]pyrene (B[a]P), a polycyclic aromatic hydrocarbon (PAH), is an ubiquitous environmental pollutant known to contribute to the development or aggravation of human diseases, such as cancer, CVDs, and immune dysfunction. Most of these deleterious effects are related to the activation of the polycyclic aromatic hydrocarbon receptor (AhR). In this context, two ethanolic microalgal extracts with concentrations of 0.1 to 5 µg/mL are tested, Ostreoccoccus tauri (OT) and Phaeodactylum tricornutum (PT), in order to evaluate and compare their potential effects towards B[a]P-induced toxicity in endothelial HMEC-1 cells. Our results indicate that the OT extract can influence the toxicity of B[a]P. Indeed, apoptosis and the production of extracellular vesicles were decreased, likely through the reduction of the expression of CYP1A1, a B[a]P bioactivation enzyme. Furthermore, the B[a]P-induced expression of the inflammatory cytokines IL-8 and IL1-β was reduced. The PT extract only inhibited the expression of the B[a]P-induced cytokine IL-8 expression. The OT extract therefore seems to be a good candidate for counteracting the B[a]P toxicity.

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Section: Discussionmentioning

confidence: 99%

Protective Action of Ostreococcus Tauri and Phaeodactylum Tricornutum Extracts towards Benzo[a]Pyrene-Induced Cytotoxicity in Endothelial Cells

Goff

Delbrut²,

Quinton³

et al. 2019

Marine Drugs

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“…Seaweeds are photosynthetic autotrophic organisms classified into different taxonomic groups, which produce a range of chemically distinct compounds [8]. Some of these compounds are not present in plants and have bioactive potential, of interest for pharmaceutics, cosmetics, and nutrition [9][10][11][12]. Seaweeds are sources of many biochemical compounds such as lipids, vitamins, proteins, polysaccharides, fibers, minerals, and others [11,[13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Marine Alkaloids with Anti-Inflammatory Activity: Current Knowledge and Future Perspectives

2020

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Alkaloids are nitrogenous compounds with various biological activities. Alkaloids with anti-inflammatory activity are commonly found in terrestrial plants, but there are few records of the identification and characterization of the activity of these compounds in marine organisms such as fungi, bacteria, sponges, ascidians, and cnidarians. Seaweed are a source of several already elucidated bioactive compounds, but few studies have described and characterized the activity of seaweed alkaloids with anti-inflammatory properties. In this review, we have gathered the current knowledge about marine alkaloids with anti-inflammatory activity and suggest future perspectives for the study and bioprospecting of these compounds.

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“…It is evident from our review that microalgae have high potential as a source of anti-lung cancer molecules, however it still needs to be extensively investigated further, in vitro and in vivo [103]. Although microalgae present high potential for producing pharmaceuticals and nutraceuticals with high antioxidant and anticancer activities, some limitations and challenges need to be addressed carefully especially before moving from laboratory to pilot and industrial scale [104].…”

Section: Economic Feasibility and Challenges In Using Microalgae For mentioning

confidence: 99%

Algae-Derived Bioactive Compounds with Anti-Lung Cancer Potential

et al. 2020

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Lung cancer is one of the major causes of death worldwide. Natural molecules with anti-lung cancer potential are of a great interest and considered as very promising alternative to substitute or enhance the efficiency of the conventional drugs. Recently, algae as source of high value-added compounds are considered as very promising source of these bioactive molecules. These are secondary metabolites that consist mainly of derivatives of peptides, carbohydrates, and lipids with various structures. Accordingly, various mechanisms by which different algae molecules demonstrate attenuation of tumor angiogenesis were stated and discussed. The mode of action of the algae bioactives is closely related to their nature and chemical structure. Furthermore, this literature review considers the synergistic effect between microalgae bioactives and conventional drugs and discuss the economic feasibility of producing microalgae bioactives at large scale to conclude with some future perspectives related to algae-based drug discovery.

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Microalgae in modern cancer therapy: Current knowledge

Cited by 148 publications

References 109 publications

Protective Action of Ostreococcus Tauri and Phaeodactylum Tricornutum Extracts towards Benzo[a]Pyrene-Induced Cytotoxicity in Endothelial Cells

Protective Action of Ostreococcus Tauri and Phaeodactylum Tricornutum Extracts towards Benzo[a]Pyrene-Induced Cytotoxicity in Endothelial Cells

Marine Alkaloids with Anti-Inflammatory Activity: Current Knowledge and Future Perspectives

Algae-Derived Bioactive Compounds with Anti-Lung Cancer Potential

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