Microalgae-based drug delivery systems in biomedical applications

Huang, Hui; Lang, Yutong; Wang, Shoujie; Zhou, Min

doi:10.1016/j.engreg.2024.01.002

Cited by 3 publications

(3 citation statements)

References 100 publications

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“…Magnetic bacteria-based bio-hybrid microrobots are a widely used living material in the field of magnetically driven diagnostics [101] as well as for targeted cancer therapy [102]. Microalgae, due to their high biocompatibility, low costs, large active surface area, strong anti-cancer drug and NPs absorption capability, phototaxis, oxygen production and high-speed of propulsion, can be successfully used as oxygenators, micro-or nanoswimmers and ideal carriers for efficient drug loading and precise targeted DDS [99,103]. Thus, Zhong et al (2020) reported the efficacy of a biodegradable microalgaebased carrier, Spirulina platensis, for the targeted delivery of doxorubicin and non-invasive fluorescence imaging-guided therapy on lung metastasis of 4T1 mouse BC cells [27].…”

Section: Nano-"magic Bullets" In Bc Theranosticsmentioning

confidence: 99%

A Nanorobotics-Based Approach of Breast Cancer in the Nanotechnology Era

Neagu,

Jayaweera,

Weraduwage

et al. 2024

IJMS

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We are living in an era of advanced nanoscience and nanotechnology. Numerous nanomaterials, culminating in nanorobots, have demonstrated ingenious applications in biomedicine, including breast cancer (BC) nano-theranostics. To solve the complicated problem of BC heterogeneity, non-targeted drug distribution, invasive diagnostics or surgery, resistance to classic onco-therapies and real-time monitoring of tumors, nanorobots are designed to perform multiple tasks at a small scale, even at the organelles or molecular level. Over the last few years, most nanorobots have been bioengineered as biomimetic and biocompatible nano(bio)structures, resembling different organisms and cells, such as urchin, spider, octopus, fish, spermatozoon, flagellar bacterium or helicoidal cyanobacterium. In this review, readers will be able to deepen their knowledge of the structure, behavior and role of several types of nanorobots, among other nanomaterials, in BC theranostics. We summarized here the characteristics of many functionalized nanodevices designed to counteract the main neoplastic hallmark features of BC, from sustaining proliferation and evading anti-growth signaling and resisting programmed cell death to inducing angiogenesis, activating invasion and metastasis, preventing genomic instability, avoiding immune destruction and deregulating autophagy. Most of these nanorobots function as targeted and self-propelled smart nano-carriers or nano-drug delivery systems (nano-DDSs), enhancing the efficiency and safety of chemo-, radio- or photodynamic therapy, or the current imagistic techniques used in BC diagnosis. Most of these nanorobots have been tested in vitro, using various BC cell lines, as well as in vivo, mainly based on mice models. We are still waiting for nanorobots that are low-cost, as well as for a wider transition of these favorable effects from laboratory to clinical practice.

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Section: Nano-"magic Bullets" In Bc Theranosticsmentioning

confidence: 99%

A Nanorobotics-Based Approach of Breast Cancer in the Nanotechnology Era

Neagu,

Jayaweera,

Weraduwage

et al. 2024

IJMS

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“…The presence of conjugated double bonds in FA acyls alters the physical properties of lipids containing them, which may help algae and higher plants adapt to demanding environments (for example, by dissipating intense light flux in high-altitude terrains [ 2 ]). Conjugated FAs appear to be a viable building material for liposome synthesis, which, in addition to their fundamental applications [ 3 ], are being intensively studied as transporters for targeted drug delivery [ 4 ], including cancer treatment [ 5 ]. Conjugated linoleic acid (CLA) has various advantages over common unsaturated FAs [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Identification of Conjugated Dienes of Fatty Acids in Vischeria sp. IPPAS C-70 under Oxidative Stress

Sidorov,

Starikov,

Sinetova

et al. 2024

IJMS

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The microalgae Vischeria sp. IPPAS C-70 produces eicosapentaenoic acid. Several stresses cause the formation of fatty acid peaks that resemble hexadecadienoic acids. We used the integrated technique including TLC, HPLC, and GC–MS to search and determine these fatty acids. Double bond positioning in these fatty acids indicated that they were conjugated dienes and allenes. We identified and described natural nine isomers of C16 polyunsaturated fatty acids, including common methylene-interrupted dienes (Δ6,9-16:2, Δ7,10-16:2, Δ9,12-16:2), and unusual conjugated dienes (Δ6,8-, Δ7,9-, Δ8,10-, Δ9,11-, and Δ10,12-16:2), as well as allenic diene (Δ9,10-16:2). We hypothesize that the formation of conjugated dienes and allenes among fatty acids is the result of oxidative stress caused by H2O2. Hydrogen peroxide also caused an increase in saturated at the expense of unsaturated fatty acids, suggesting inhibition either fatty acid desaturases activities or the corresponding gene expression.

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“…Recently, the O 2 production by photosynthetic microorganisms, mainly by algae, has attracted more attention due to its sustained and controllable O 2 supply [17][18][19][20]. In 2006, Bloch et al first develop an immuno-islet transplant device using Chlorella sorokiniana and alginate hydrogel, initiating the photosynthesis-dependent O 2 production to induce a higher insulin response [21].…”

Section: Introductionmentioning

confidence: 99%

Photosynthetic co‐culture system of algae and human umbilical vein endothelial cells: The effect on alleviating hypoxia and hypoxia/reoxygenation injury

Lin,

Chen,

Tao

et al. 2024

Biosurface and Biotribology

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It is a developed photosynthetic co‐culture system to alleviate the hypoxia and hypoxia/reoxygenation (H/R)‐injured human umbilical vein endothelial cells (HUVECs). The algae, Chlorella vulgaris, were encapsulated to slow their growth while not affecting the photosynthetic oxygen‐producing capacity by Layer‐by‐layer (LbL) using gelatin and sodium alginate as the positive and negative charges materials, respectively. Then, the photosynthetic co‐culture system of HUVECs and self‐oxygenating alginate hydrogel (Algae‐gel) was constructed in which the optimal ratios between algae and HUVECs were 5:1 and 20:1 for a 2D or 3D co‐cultured manner, respectively. It indicated that the 3D co‐cultured manner of HUVECs needed more O2 by the production of algae than it did in a 2D co‐cultured manner. The co‐cultured Algae‐gel could alleviate hypoxia and the oxidative stress injury of hypoxia and hypoxia/reoxygenation (H/R)‐treated HUVECs in the proliferation, intracellular ROS and cellular migratory ability. In addition, the Algae‐gel could downregulate the expression of hypoxia‐inducible factors 1α (HIF‐1α) and vascular endothelial growth factor (VEGF) of hypoxia and H/R‐injured HUVECs due to the improvement of hypoxia and H/R injury. This photosynthetic co‐culture system could offer a promising approach for repairing hypoxia and H/R‐injured cells or tissue by providing safe and stable O2.

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Microalgae-based drug delivery systems in biomedical applications

Cited by 3 publications

References 100 publications

A Nanorobotics-Based Approach of Breast Cancer in the Nanotechnology Era

A Nanorobotics-Based Approach of Breast Cancer in the Nanotechnology Era

Identification of Conjugated Dienes of Fatty Acids in Vischeria sp. IPPAS C-70 under Oxidative Stress

Photosynthetic co‐culture system of algae and human umbilical vein endothelial cells: The effect on alleviating hypoxia and hypoxia/reoxygenation injury

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