Microalga Chlorella sp. extract induced apoptotic cell death of cholangiocarcinoma via AKT/mTOR signaling pathway

Sawasdee, Nunghathai; Jantakee, Kanyaluck; Wathikthinnakon, Methi; Panwong, Suthida; Pekkoh, Jeeraporn; Duangjan, Kritsana; Yenchitsomanus, Pa‐thai; Panya, Aussara

doi:10.1016/j.biopha.2023.114306

Cited by 5 publications

(4 citation statements)

References 22 publications

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“…Several effects were observed: a reduction in procaspase-3, -8, and -9; an increase in the enzymatic activity of caspase and a reduction in the anti-apoptosis protein Bcl-2 (which induce cell death); and a reduction in the proteins phosphorylate-AKT and phosphorylate-mTOR, which led to inhibition of AKT/mTOR survival signaling. In all types of tumor cells considered, there was growth inhibition [ 129 ].…”

Section: Lutein: a Versatile Antioxidant In Human Healthmentioning

confidence: 99%

Lutein Production and Extraction from Microalgae: Recent Insights and Bioactive Potential

Montuori,

Lima,

Marchese

et al. 2024

IJMS

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Microalgae have been reported to be excellent producers of bioactive molecules. Lutein is a pigment reported to have various beneficial effects for humans, and especially for eye well-being. In the current review, we summarize various methods that have been developed to optimize its extraction and bioactivities reported for human health. Several protective effects have been reported for lutein, including antioxidant, anticancer, anti-inflammatory, and cardioprotective activity. This review also reports attempts to increase lutein production by microalgae by changing culturing parameters or by using pilot-scale systems. Genetic engineering lutein production is also discussed. Considering the increasing aging of the worldwide population will create an increased need for lutein, a viable economic and eco-sustainable method to produce lutein is needed to face this market demand.

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Section: Lutein: a Versatile Antioxidant In Human Healthmentioning

confidence: 99%

Lutein Production and Extraction from Microalgae: Recent Insights and Bioactive Potential

Montuori,

Lima,

Marchese

et al. 2024

IJMS

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“…Chlorella is a single-celled algae whose main property is detoxifying tissues from heavy metals and providing nutrients and vitamins [ 96 ]. The impact of ethanol and polysaccharide extracts from algae was evaluated by Nunghathai Sawasdee et al in terms of HCC cell survival, with the results indicating anti-cancer effects [ 97 ]. Carotenoids and epigallocatechin gallate have been identified in studies using the applied extract [ 97 ].…”

Section: Selected Food Products With Hepatoprotective Propertiesmentioning

confidence: 99%

“…The impact of ethanol and polysaccharide extracts from algae was evaluated by Nunghathai Sawasdee et al in terms of HCC cell survival, with the results indicating anti-cancer effects [ 97 ]. Carotenoids and epigallocatechin gallate have been identified in studies using the applied extract [ 97 ]. Ragaa A. Hamouda et al demonstrated the anti-cancer effect of methanol extract from chlorella on HCC [ 98 ].…”

Section: Selected Food Products With Hepatoprotective Propertiesmentioning

confidence: 99%

The Influence of Diet and Its Components on the Development and Prevention of Hepatocellular Carcinoma (HCC)

Janota,

Szymanek

2024

Cancers

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Hepatocellular carcinoma (HCC) is diagnosed annually in nearly a million people worldwide, with approximately half of them being diagnosed at an advanced stage of the disease. Non-infectious risk factors for the development of HCC include an unbalanced lifestyle, including poor dietary choices characterized by a low intake of antioxidants, such as vitamins E and C, selenium, and polyphenols, as well as an excessive consumption of energy and harmful substances. Repeated bad dietary choices that contribute to an unbalanced lifestyle lead to the accumulation of fatty substances in the liver and to it entering an inflammatory state, which, without intervention, results in cirrhosis, the main cause of HCC. This review of the English language literature aims to present the food components that, when included in the daily diet, reduce the risk of developing HCC, as well as identifying foods that may have a carcinogenic effect on liver cells.

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“…[1,2] Nowadays microalgae are increasingly used in industry as a feed for farmed fish or livestock, [3][4][5] as well as the production of food, drugs or drug components such as 𝛽-carotene for humans, [6,7] omega-3 polyunsaturated fatty acid, [8][9][10][11] food colorings including astaxanthin, [7,12] and phycoerythrin, [13][14][15] and many other carotenoid antioxidants with anticancer and anti-inflammatory activities. [16][17][18][19][20] Gene engineered microalgae have been tested in protein drug development [21] and edible vaccine production. [22][23][24] Many strains of microalgae are rich in vitamins, antioxidants, proteins, and lipids and low in carbohydrates therefore they are considered as healthy food compounds.…”

Section: Introductionmentioning

confidence: 99%

Recent advances and fundamentals of microalgae cultivation technology

Rozenberg,

Sorokin,

Mukhambetova

et al. 2024

Biotechnology Journal

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Microalgae are considered to be a promising group of organisms for fuel production, waste processing, pharmaceutical applications, and as a source of food components. Unicellular algae are worth being considered because of their capacity to produce comparatively large amounts of lipids, proteins, and vitamins while requiring little room for growth. They can also grow on waste and fix CO2 and nitrogen compounds. However, production costs limit the industrial use of microalgae to the most profitable applications including micronutrient production and fish farming. Therefore, novel microalgae based technologies require an increase of the production efficiencies or values. Here we review the recent studies focused on getting strains with novel characteristics or cultivating techniques that improve production's robustness or efficiency and categorize these findings according to the fundamental factors that determine microalgae growth. Improvements of light and nutrient delivery, as well as other aspects of photobioreactor design, have shown the highest average increase in productivity. Other methods, such as an improvement of phosphorus or CO2 fixation and temperature adaptation have been found to be less effective. Furthermore, interactions with particular bacteria may promote the growth of microalgae, although bacterial and grazer contaminations must be managed to avoid culture failure. The competitiveness of the algal products will increase if these discoveries are applied to industrial settings.

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Microalga Chlorella sp. extract induced apoptotic cell death of cholangiocarcinoma via AKT/mTOR signaling pathway

Cited by 5 publications

References 22 publications

Lutein Production and Extraction from Microalgae: Recent Insights and Bioactive Potential

Lutein Production and Extraction from Microalgae: Recent Insights and Bioactive Potential

The Influence of Diet and Its Components on the Development and Prevention of Hepatocellular Carcinoma (HCC)

Recent advances and fundamentals of microalgae cultivation technology

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