Microalbuminuria in Patients With NIDDM: An Overview

Alzaid, Aus

doi:10.2337/diacare.19.1.79

Cited by 100 publications

(58 citation statements)

References 45 publications

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“…In favour of this view, are the observations indicating that tighter blood glucose control reduces the incidence and progression of cardiovascular complications and of diabetic nephropathy. 7,23,24 In addition, subsequent development of hypertension and/or worsening or existing hypertension elevation of the BP, and development of a state of salt sensitivity, may also play a role in the development of microalbuminuria. 25 Because of the well-known male and female pattern of body fat distribution, 16 we separately evaluated the relationships between abdominal fat and albuminuria in males and females.…”

Section: Discussionmentioning

confidence: 99%

“…[3][4][5][6][7] Moreover, it has been reported that even in non-diabetic subjects the presence of microalbuminuria may be associated with increased atherosclerotic risk factors and cardiovascular morbidity and mortality. [8][9][10][11] However, what determines microalbuminuria in normotensive nondiabetic subjects is unknown.…”

Section: Journal Of Human Hypertension (2001) 15 407-412mentioning

confidence: 99%

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Urinary albumin excretion in lean, overweight and obese glucose tolerant individuals: its relationship with dyslipidaemia, hyperinsulinaemia and blood pressure

2001

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The presence of microalbuminuria has become an important tool for therapeutic intervention. In this study we investigated whether the dysmetabolic syndrome of obesity was associated with or could occur in the absence of microalbuminuria. The study was conducted in 71 clinically healthy, glucose tolerant Hispanics (age: 43 ؎ 1.4 years, body mass index (BMI): 28.7 ؎ 0.6 kg/m 2 , systolic blood pressure (SBP): 117 ؎ 2 mm Hg, diastolic blood pressure (DBP): 77 ؎ 1.3 mm Hg, urinary albumin excretion: 10.2 ؎ 0.6 mg/24 h). Subjects were classified as lean (BMI Ͻ25), overweight (BMI Ͼ25 Ͻ30) and obsese (BMI Ͼ30 kg/m 2 ). Greater BMI was associated with higher body weight, waist-to-hip ratio (WHR), BP, fasting insulin, triglyceride, post glucose load insulin and glucose, and lower high-density lipoprotein (HDL) cholesterol levels. However, no significant differences in the urinary albumin excretion (mg/24 h) were found between lean (9.0 ؎ 0.9; median: 9.1), overweight (11.3 ؎ 1.2; median: 10.5) and obese (11.1 ؎ 1.2; median: 9.7) subjects. In addition, microalbuminuria

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Section: Discussionmentioning

confidence: 99%

Section: Journal Of Human Hypertension (2001) 15 407-412mentioning

confidence: 99%

Urinary albumin excretion in lean, overweight and obese glucose tolerant individuals: its relationship with dyslipidaemia, hyperinsulinaemia and blood pressure

2001

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“…Urine samples from healthy Saudi subjects without any history of renal disease, hypertension or diabetes mellitus were free of glucose, had normal pH values and NAG [17] , AAP [18] , microalbuminuria [19] and total protein values ( Table 1). No significant differences were found between males and females, data was then pooled for the whole group.…”

Section: Normal Subjectsmentioning

confidence: 99%

Urinary Enzymes and Microalbuminuria as Indicators of Renal Nephropathy in Saudi Patients

Lary¹

2008

sci

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Abstract. In the current work we tried to investigate some new biochemical markers in the urine of kidney patients, kidney transplant recipients and control subjects of the Saudi population, such markers are N-acetyl-β-D-glucosaminidase (NAG), Alkaline Phosphatase (ALP), Alanine Aminopeptidase (AAP) as well as microalbuminuria. Kidney patients, males and females, age ranged from 16-85 years, and kidney transplant recipients, male and female, age ranged from 18-75 years.Results from control subjects showed a slight elevation of total urinary protein and NAG in females. This may be due to the higher level of creatinine concentration in male subjects, that would result in lower protein concentration and NAG activity when expressed in terms of creatinine. Microalbuminuria, glucose and pH results were in close agreement with the published data and no sex differences were recorded when compared with the males. There were statistically significant differences in most of parameters investigated between kidney patients and the normal population except for glucose level and pH value. The reduction in creatinine concentration may reflect changes in the glomerular filtration rate (GRF). Higher levels of urinary NAG activity were associated with high microalbuminuria and raised AAP levels.Increase urinary NAG predominantly reflects decreased renal function and tubular damage. ALP increased levels reflect a lesion of the proximal convoluted tubules and/or intensive degeneration of the tubular epithelial cells. The increase in NAG activity correlates well with urinary protein and may indicate an increase in activity of renal tubular cells. Kidney transplant recipients showed a significant increase in NAG, ALP and AAP enzymes compared to control subjects. The marked increase in most parameters may indicate that patients are in an immediate functioning graft.

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“…An ACR of 2.0 -2.5 mg/mmol to 20-35 mg/mmol corresponds to albumin excretion of 20 -200 µg/min or 30 -300 mg/day. 27,28,29 In this study control subjects mean±2SD of urinary albumin creatinine ratio (ACR) was 2.77 mg/mmol. ACR 2.77mg/mmol was taken as a cut-off value.…”

Section: Introductionmentioning

confidence: 99%

Raised Arterial Pressure and Microalbuminuria in Type 2 Diabetic Subjects with Familial Hypertension

Rahman

Billah

Mitra

et al. 2016

Bangladesh Crit Care J

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Background and Aims : Microalbuminuria is claimed to be an early marker of nephropathy in type 2 diabetes.The raised arterial pressure is an important factor in the progression of diabetic nephropathy. There is a significant correlation between blood pressure and the progression of albuminuria in both type 1 and type 2 diabetes. This study in Bangladeshi type 2 diabetic patients was to evaluate whether microalbuminuria and raised arterial pressure are influenced by familial predisposition to hypertension.Methods : Sixty three newly diagnosed Bangladeshi type 2 diabetic patients were investigated. The diabetic subjects were divided into two groups as diabetes with family history of hypertension (n=37) and diabetes without family history of hypertension (n=26). Diabetic subjects were further divided into normotensive (n= 46) and hypertensive (n= 17); diabetic normoalbuminuric (n 44) and diabetic microalbuminuric (n 19) subgroups. Serum glucose was measured by glucose-oxidase; blood urea, serum creatinine and urinary creatinine by enzymatic-colorimetric method and urinary albumin by immunoturbidimetry method.Results : systolic blood pressure (SBP), diastolic blood pressure (DBP) and microalbuminuria were significantly elevated in diabetic subjects with familial predisposition to hypertension when compared to diabetic subjects without familial predisposition to hypertension [SBP (127±16 vs 110±14) mmHg P= 0.001; DBP (81±9 vs 72±11) mmHg P= 0.001; Microalbuminuria 2.23(0.28-9.43) vs 1.52(.29-3.91) mg/mmol p<0.03]. When diabetic normotensive subjects were compared with diabetic hypertensive subjects for microalbuminuria, no significant difference was found among themselves [median (range) 1.67(0.17-8.62) vs 1.70(.28-9.43) mg/mmol p = NS]. Comparison of blood pressure was found no significant difference between diabetic normoalbuminuric and diabetic microalbuminuric subjects [systolic blood pressure (117±17 vs 125±17) mmHg p= NS ; diastolic blood pressure (76±11 vs 82±10) mmHg p= NS ].Conclusion : Microalbuminuria, a marker of early diabetic nephropathy and raised arterial pressure, a progression factor of nephropathy are more influenced by familial predisposition to hypertension in diabetic population irrespective of presence or absence of microalbuminuria and hypertension.Bangladesh Crit Care J March 2016; 4 (1): 14-18

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Microalbuminuria in Patients With NIDDM: An Overview

Cited by 100 publications

References 45 publications

Urinary albumin excretion in lean, overweight and obese glucose tolerant individuals: its relationship with dyslipidaemia, hyperinsulinaemia and blood pressure

Urinary albumin excretion in lean, overweight and obese glucose tolerant individuals: its relationship with dyslipidaemia, hyperinsulinaemia and blood pressure

Urinary Enzymes and Microalbuminuria as Indicators of Renal Nephropathy in Saudi Patients

Raised Arterial Pressure and Microalbuminuria in Type 2 Diabetic Subjects with Familial Hypertension

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