Microalbuminuria in Obesity

Løkkegaard, Niels; Haupter, Ilia; Kristensen, Troels B.

doi:10.3109/00365599209180882

Cited by 27 publications

(22 citation statements)

References 17 publications

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“…This could reflect coinheritance of obesity and predisposition to microalbuminuria. Obesity in itself, especially abdominal obesity, has also been associated with increased AER [25,26]. Further, it has been found that higher BMI predicted higher AER in diabetic siblings of Type II diabetic probands with and without albuminuria [27].…”

Section: Discussionmentioning

confidence: 99%

Heritability of albumin excretion rate in families of patients with Type II diabetes

Forsblom

Kanninen²,

Lehtovirta

et al. 1999

Diabetologia

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Diabetic nephropathy develops in up to 30 % of patients with Type I (insulin-dependent) diabetes mellitus after 30 years duration, whereas the cumulative risk in Type II (non-insulin-dependent) diabetes mellitus varies between 25 and 50 % depending upon ethnic background and age at onset [1±3]. Although hyperglycaemia in itself represents the most important single risk factor for the development of diabetic nephropathy, genetic predisposition is also considered to have an important role. A familial clustering of diabetic nephropathy has been shown in both Type I and Type II diabetes [4±6]. Therefore an intensive search for genes which increase susceptibility to diabetic nephropathy has been initiated.For genetic studies it is essential to correctly define the phenotype as early as possible. Microalbuminuria has served this purpose as it predicts diabetic nephropathy in both Type I and Type II diabetes [7±10]. Microalbuminuria is, however, also associated with cardiovascular disease [11] and it is not entirely clear whether the same genetic mechanisms confer suscep- Diabetologia (1999) AbstractAims/hypothesis. To study whether albumin excretion rate is an inherited trait in families of patients with Type II (non-insulin-dependent) diabetes mellitus. Methods. We used three different approaches. Heritability of albumin excretion rate was studied in 267 nuclear families from the Botnia Study in Western Finland using parent-offspring regression. Albumin excretion rate was also measured in 206 non-diabetic offspring of 119 Type II diabetic parents with or without albuminuria (albumin excretion rate > 20 mg/ min). Finally, albumin excretion rate was measured in altogether 652 siblings of 74 microalbuminuric and 320 normoalbuminuric probands. To study the potential confounding effect of blood pressure, the heritability of blood pressure was estimated in 718 nuclear families.Results. Using parent-offspring regression, the heritability of albumin excretion rate was about 30 %, being the strongest from mothers to sons (35±39 % resemblance). The heritability for systolic blood pressure ranged from 10 to 20 % and for diastolic blood pressure from 10 to 27 %. Offspring of albuminuric Type II diabetic parents had higher albumin excretion rates (median 5.

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Section: Discussionmentioning

confidence: 99%

Heritability of albumin excretion rate in families of patients with Type II diabetes

Forsblom

Kanninen²,

Lehtovirta

et al. 1999

Diabetologia

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“…Not surprisingly, therefore, essential hypertensive patients with microalbuminuria frequently showed either mild fasting hyperglycaemia or a hyperglycaemic response to oral glucose loading. [63][64][65][66][67][68][69][70][71][72] Since a worse glucose tolerance is part of the so-called metabolic syndrome X, 73 slight elevations in UAE were also associated with its typical phenotypes, ie, hyperinsulinaemia, [63][64][65][66][67][68][69][70][71][72]74 insulin resistance, 67,68 high triglycerides and low high-density lipoprotein (HDL), 25,75,76 overweight-obesity 18,77,78 and BP sensitivity to increased sodium intake. 79 Increased concentrations of total and low-density lipoprotein (LDL)-cholesterol sometimes reported in hypertensive patients with microalbuminuria 3 have raised the intriguing possibility of a link between microalbuminuria and atherogenic lipids unrelated to the trait of the syndrome X, but the results of large-scale studies 14,18 seem to contradict that possibility.…”

Section: 4957-59mentioning

confidence: 99%

Microalbuminuria, an integrated marker of cardiovascular risk in essential hypertension

et al. 2002

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This paper reviews the existing epidemiological and clinical evidence about the relationships of non-diabetic microalbuminuria with cardiovascular risk factors such as elevated blood pressure (BP), systolic particularly, cardiac hypertrophy, adverse metabolic status, smoking habits, elevated angiotensin II levels, endothelial dysfunction, acute and perhaps subclinical inflammation. Because of that unique property of reflecting the influence of so many clinically relevant parameters, microalbuminuria may legitimately be defined as an integrated marker of cardiovascular risk, an unique profile among the several prognostic predictors available to

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“…BMI and WHR are independent risk factors for cardiovascular mortality [12], and the BMI has been shown to be positively correlated with urinary albumin excretion [13,14]. However, a difference has not been shown in renal function between obese subjects with the same %TBF but with a different distribution of this fat.…”

Section: Introductionmentioning

confidence: 99%

Body Fat Distribution and Total Body Fat as Risk Factors for Microalbuminuria in the Obese

et al. 2001

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Background/Aim: Despite evidence linking type of obesity with subsequent organ malfunction, such a link with renal malfunction has not been widely researched. The aim of this study was to investigate percentage of total body fat (%TBF), and body fat distribution in relation to the renal function in overweight/obese subjects. Methods: Body mass index (BMI), waist-to-hip ratio (WHR), TBF (by bioelectric impedance), and albumin excretion rate (AER) were determined in 77 subjects: 48 overweight/obese (BMI ≧27.8 for men and ≧27.3 for women) and 29 controls (BMI <27.8 for men and <27.3 for women). Obese subjects were subdivided into those (n = 33) with central fat distribution (WHR ≧0.81 for women and ≧0.92 for men) and those (n = 15) with peripheral fat distribution (WHR <0.81 for women and <0.92 for men). Results: Obesity, irrespective of type, was significantly related to increased AER. Furthermore, in subjects who did not differ in %TBF, the age-adjusted relative risk of abnormal AER was 18 times greater in centrally obese subjects as compared with controls, while only four times greater in peripherally obese subjects. Conclusion: A significant difference in risk of renal malfunction was observed in individuals having the same %TBF, but differing in the distribution of this fat, with a central fat pattern being the greater risk.

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Microalbuminuria in Obesity

Cited by 27 publications

References 17 publications

Heritability of albumin excretion rate in families of patients with Type II diabetes

Heritability of albumin excretion rate in families of patients with Type II diabetes

Microalbuminuria, an integrated marker of cardiovascular risk in essential hypertension

Body Fat Distribution and Total Body Fat as Risk Factors for Microalbuminuria in the Obese

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