Microalbuminuria as a subclinical marker of renal impairment in subjects with psoriasis vulgaris

Jc, Szepietowski; Bielicka, E; Wa̧sik, F; Kopeć, W; Szepietowski, T

doi:10.1046/j.1468-3083.2000.00119.x

Cited by 23 publications

(20 citation statements)

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“…We therefore recommend always asking women with psoriasis about vulvar symptoms and examining the whole patient including the genital region. It was demonstrated recently that psoriatic patients also have increased risk of other systemic diseases, including myocardial infarction, heart arrhythmia, diabetes mellitus and metabolic syndrome (13)(14)(15)(16)(17). Taken together, strong evidence exists that psoriasis is not only a dermatoiogical disorder with skin involvement, but represents a disease with significant internal organ and psychiatric co-morbidity.…”

Section: Discussionmentioning

confidence: 99%

Vulvar Pruritus and Burning Sensation in Women with Psoriasis

Zamirska¹,

Reich²,

Berny-Moreno³

et al. 2008

Acta Derm Venereol

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Approximately 80% of psoriatic individuals experience pruritus, of varying intensity. This study evaluated the frequency of vulvar itching and burning and its influence on well-being in women with psoriasis. A total of 93 women were included in the study. Psoriasis severity was assessed according to the Psoriasis Area and Severity Index, the intensity of vulvar discomfort by visual analogue scale and depressive symptoms by Beck's Depression Inventory. On admission 41 (44.1%) women experienced vulvar discomfort, 18 (19.4%) itching, 10 (10.8%) burning and 13 (14.0%) both itching and burning sensations. Psoriatic lesions on the vulva were found in 22 (23.7%) women. No significant correlation was found between burning or itching intensity and global psoriasis severity (r = 0.19, p = 0.26). Patients with vulvar discomfort had psoriatic lesions on the vulva more often than women without discomfort (43.6% vs. 8.2%, p < 0.001). In addition, patients with vulvar discomfort more frequently demonstrated depressive symptoms (p < 0.05). We conclude that vulvar discomfort is an important clinical problem in women with psoriasis and should be taken into consideration during treatment.

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Section: Discussionmentioning

confidence: 99%

Vulvar Pruritus and Burning Sensation in Women with Psoriasis

Zamirska¹,

Reich²,

Berny-Moreno³

et al. 2008

Acta Derm Venereol

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“…Although psoriasis is a common chronic inflammatory disorder of the skin, increasing evidence has demonstrated that psoriasis is associated with an increased risk of CKD and urinary albumin excretion [26, 27]. A population-based cohort study demonstrated that moderate to severe psoriasis was associated with an increased risk of CKD, independent of traditional risk factors [10].…”

Section: Discussionmentioning

confidence: 99%

PLA2R antibodies and PLA2R glomerular deposits in psoriasis patients with membranous nephropathy

Jin

Zeng

et al. 2016

BMC Nephrol

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BackgroundThe association between psoriasis and membranous nephropathy (MN) remains largely unclear. We examined the prevalence of serum PLA2R antibody and characterized the expression of PLA2R and THSD7A in glomeruli in patients with MN and psoriasis.MethodsA total of 24 patients with MN without evidence of a secondary cause except psoriasis were enrolled. The clinical and pathological features were retrospectively analyzed. Serum anti-PLA2R antibody was measured using IFA Mosaic. Renal tissue samples stored in the laboratory bio-bank were used for PLA2R staining under immunofluorescence microscopy and THSD7A immunohistochemical analysis.ResultsTwenty-four patients (21 male and 3 female) with a mean age of 43.6 ± 15.7 years old were enrolled. Serum anti-PLA2R antibody was positive in 7 patients, which was significantly lower than the positivity observed in idiopathic MN (29.2% vs. 81.7%, P < 0.001). Glomerular PLA2R staining was positive in 7 patients with positive serum anti-PLA2R antibody. THSD7A staining was negative in all 24 patients. During the follow-up visits, 13 patients with negative serum PLA2R antibody achieved CR. In contrast, CR was only achieved in 1 patient with positive serum PLA2R antibody, PR was achieved in 2 patients.ConclusionsThe prevalence of serum anti-PLA2R antibody and glomerular expression of PLA2R was significantly lower in patients with psoriasis and MN than in those with idiopathic MN, and THSD7A staining was negative, suggesting that MN is associated with psoriasis in the majority of patients. However, idiopathic MN might also accompany psoriasis in a minority of psoriatic patients with positive serum anti-PLA2R antibody.

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“…Plaque type psoriasis of the lips has been described in association with psoriasis of the tongue, presenting whitish or grayish roundish polycyclic or annular plaques with an erythematous halo of the tongue, palate and gingiva and a fissured or geographic tongue [ 7 , 8 ]. The clinical differential diagnosis must consider irritative cheilitis, chronic eczema, leucoplakia, actinic cheilitis and chronic candidiasis [ 9 ]. In our case, these conditions were not supported by histology.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, unlike keratinized stratified squamous epithelium of the skin, the transitional and mucosal epithelia do not contain corneodesmosin, an epidermal glycoprotein involved in keratinocyte adhesion, an allelic variant of which has been strongly associated with the development of psoriasis [ 8 , 10 ]. It is well known that traumas, stress and streptococcal infection can precipitate psoriasis; therefore mild traumas, e.g., chronic friction from protruding teeth, or environmental changes in infection can lead to psoriatic lesions on the lips, especially in a genetically predisposed subject [ 9 , 11 ].…”

Section: Discussionmentioning

confidence: 99%