Microalbuminuria

Gumbinger, Christoph; Sýkora, Marek; Diedler, Jennifer; Ringleb, Peter A.; Rocco, Andrea

doi:10.1007/s00115-012-3678-3

Cited by 8 publications

(4 citation statements)

References 15 publications

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“…The ROC analysis demonstrated that microalbuminuria outperformed other risk factors in predicting poor early functional outcomes, as evidenced by its higher AUC. These results align with studies highlighting microalbuminuria as an independent prognostic marker for adverse outcomes and increased short-term mortality [ 24 , 25 ].…”

Section: Discussionsupporting

confidence: 90%

Microalbuminuria as a Predictor of Early Neurological Deterioration and Poor Functional Outcomes in Acute Ischemic Stroke

Pavuluri,

Pathi,

Dash

et al. 2024

Cureus

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Background Ischemic stroke is a major health crisis with significant consequences. Microalbuminuria, a sign of endothelial dysfunction, has been linked to adverse outcomes in ischemic stroke. Early neurological deterioration (END) is a critical factor influencing the patient’s prognosis. This study aimed to determine the prevalence of microalbuminuria, its predictive value in assessing END, and its prognostic implications in acute ischemic stroke (AIS). Methodology This study conducted at Pradyumna Bal Memorial Hospital, Kalinga Institute of Medical Sciences Bhubaneswar (November 2020-April 2022) included 114 AIS patients over 18 years who presented within 24 hours of stroke onset. Demographics, vascular risk factors, National Institutes of Health Stroke Scale (NIHSS) scores (admission and day three), modified Rankin scores (day 10), urinary albumin-to-creatinine ratios, and carotid artery Doppler studies were collected. Results The mean age of the patients was 61.87 years, with males constituting 72.8% of the population. Hypertension (50.9%) and diabetes mellitus (28.9%) were the most common comorbid conditions. The mean NIHSS stroke severity at presentation was 11.30. END occurred in 38.6% of patients. Overall, 43.9% of cases showed carotid stenosis, and the mean carotid intimal media thickness was 1.08 mm. Notably, the presence of microalbuminuria significantly increased the chances of both END (39.45 times higher risk) and worse functional outcomes (odds ratio = 19.147, p = 0.001). Conclusions Microalbuminuria emerges as a robust independent predictor of END and a poor prognosis in AIS. These findings highlight the importance of early microalbuminuria identification and intervention to reduce END risk and potentially improve outcomes in AIS patients.

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Section: Discussionsupporting

confidence: 90%

Microalbuminuria as a Predictor of Early Neurological Deterioration and Poor Functional Outcomes in Acute Ischemic Stroke

Pavuluri,

Pathi,

Dash

et al. 2024

Cureus

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“…Microalbuminuria is considered a notable risk-factor for cerebrovascular diseases [ 36 , 37 , 38 ]. Microalbuminuria has been widely related to the severity of ischemic stroke, hemorrhagic transformation, and poor clinical outcomes [ 31 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 ]. In the present study, we demonstrated an increased risk of developing m-MCA in patients with elevated levels of microalbuminuria.…”

Section: Discussionmentioning

confidence: 99%

Antihyperthermic Treatment in the Management of Malignant Infarction of the Middle Cerebral Artery

Alonso-Alonso¹,

Sampedro-Viana²,

Rodríguez‐Yáñez

et al. 2022

JCM

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Malignant infarction of the middle cerebral artery (m-MCA) is a complication of ischemic stroke. Since hyperthermia is a predictor of poor outcome, and antihyperthermic treatment is well tolerated, our main aim was to analyze whether the systemic temperature decrease within the first 24 h was associated with a better outcome. Furthermore, we studied potential biochemical and neuroimaging biomarkers. This is a retrospective observational analysis that included 119 patients. The temperature variations within the first 24 h were recorded. Biochemical laboratory parameters and neuroimaging variables were also analyzed. The temperature increase at the first 24 h (OR: 158.97; CI 95%: 7.29–3465.61; p < 0.001) was independently associated with a higher mortality. Moreover, antihyperthermic treatment (OR: 0.08; CI 95%: 0.02–0.38; p = 0.002) was significantly associated with a good outcome at 3 months. Importantly, antihyperthermic treatment was associated with higher survival at 3 months (78% vs. 50%, p = 0.003). Significant independently associations between the development of m-MCA and both microalbuminuria (OR: 1.01; CI 95%: 1.00–1.02; p = 0.005) and leukoaraiosis (OR: 3.07; CI 1.84–5.13–1.02; p < 0.0001) were observed. Thus, antihyperthermic treatment within the first 24 h was associated with both a better outcome and higher survival. An increased risk of developing m-MCA was associated with leukoaraiosis and an elevated level of microalbuminuria.

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“…A condition commonly encountered in urological and nephrological practice [7], MA is a consequence of altered glomerular permeability, which could be the result of pathophysiological events such as hypertension or diabetes mellitus [8][9][10]. Recent studies have shown that MA may be associated with an increased risk of cardiovascular events and mortality [11,12]. Furthermore, MA has been identified as a marker of organ damage, such as left ventricular hypertrophy and atherosclerosis, and as a predictor of hypertension and diabetes complications [13].…”

Section: Introductionmentioning

confidence: 98%

Predictive modeling using a nationally representative database to identify patients at risk of developing microalbuminuria

et al. 2015

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Microalbuminuria

Cited by 8 publications

References 15 publications

Microalbuminuria as a Predictor of Early Neurological Deterioration and Poor Functional Outcomes in Acute Ischemic Stroke

Microalbuminuria as a Predictor of Early Neurological Deterioration and Poor Functional Outcomes in Acute Ischemic Stroke

Antihyperthermic Treatment in the Management of Malignant Infarction of the Middle Cerebral Artery

Predictive modeling using a nationally representative database to identify patients at risk of developing microalbuminuria

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