Micro-vascular complications of post-transplant diabetes mellitus in renal transplant recipients- an observational study

Abdullah,; Momin, Indrajeet; Kaul, Anupma; Bhadauria, Dharmendra; Prasad, Narayan; Behera, Manas; Patel, Manas; Kushwaha, Ravi; Yachha, Monika; Srivastava, Aneesh

doi:10.1016/j.trim.2024.102012

Transplant Immunology

2024

DOI: 10.1016/j.trim.2024.102012

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Micro-vascular complications of post-transplant diabetes mellitus in renal transplant recipients- an observational study

Abdullah,

Indrajeet Momin,

Anupma Kaul

et al.

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Management of diabetes in people with advanced chronic kidney disease

Chowdhury,

Mukuba,

Casabar

et al. 2024

Diabet Med

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Diabetes is the commonest cause of end stage kidney disease globally, accounting for almost 40% of new cases requiring renal replacement therapy. Management of diabetes in people with advanced kidney disease on renal replacement therapy is challenging due to some unique aspects of assessment and treatment in this group of patients. Standard glycaemic assessment using glycated haemoglobin may not be valid in such patients due to altered red blood cell turnover or iron/erythropoietin deficiency, leading to changed red blood cell longevity. Therefore, use of continuous glucose monitoring may be beneficial to enable more focussed glycaemic assessment and improved adjustment of therapy. People with advanced kidney disease may be at higher risk of hypoglycaemia due to a number of physiological mechanisms, and in addition, therapeutic options are limited in such patients due to lack of experience or license. Insulin therapy is the basis of treatment of people with diabetes with advanced kidney disease due to many other drugs classes being contraindicated. Targets for glycaemic control should be adjusted according to co‐morbidity and frailty, and continuous glucose monitoring should be used in people on dialysis to ensure low risk of hypoglycaemia. Post‐transplant diabetes is common amongst people undergoing solid organ transplantation and confers a greater risk of mortality and morbidity in kidney transplant recipients. It should be actively screened for and managed in the post‐transplant setting.

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Management of diabetes in people with advanced chronic kidney disease

Chowdhury,

Mukuba,

Casabar

et al. 2024

Diabet Med

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show abstract

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Micro-vascular complications of post-transplant diabetes mellitus in renal transplant recipients- an observational study

Cited by 1 publication

References 28 publications

Management of diabetes in people with advanced chronic kidney disease

Management of diabetes in people with advanced chronic kidney disease

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