Micro-sized photo-detecting stimulator array for retinal prosthesis by distributed sensor network approach

Uehara, Akihiro; Pan, Yi-Li; Kagawa, Keiichiro; Tokuda, Takashi; Nunoshita, Masahiro

doi:10.1016/j.sna.2004.11.023

Cited by 11 publications

(4 citation statements)

References 23 publications

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“…In order to overcome the issue of mechanical rigidity and realize a feasible LSI-based device, we have proposed a device architecture consisting of small microchips that work under a single set of control signals [14], [15]. Fig.…”

Section: A Multiple Microchip-based Stimulatormentioning

confidence: 99%

Si-LSI Based Stimulators for Retinal Prosthesis

Ohta

Kagawa

Uehara

et al. 2007

2007 International Joint Conference on Neural Networks

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In this presentation, we demonstrate a pulsefrequency-modulation (PFM)-based retinal stimulator for subretinal implantation using standard CMOS technology with low voltage operation of 1.2 V. A PFM-based photosensor converts input light intensity to electrical pulse trains whose frequency is proportional to the input light intensity. To employ simple image processing function, 1-bit pulse domain operation is introduced and demonstrated. A packaging technology for ocular implantation is also discussed. We have proposed and demonstrated a multi-chip architecture with expandability of the number of stimulus electrodes and flexibility of bending along the eye-ball. A fabricated stimulator based on this architecture is implanted in a rabbit eye and achieved to obtain EEP (electrical evoked potential) signals.

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Section: A Multiple Microchip-based Stimulatormentioning

confidence: 99%

Si-LSI Based Stimulators for Retinal Prosthesis

Ohta

Kagawa

Uehara

et al. 2007

2007 International Joint Conference on Neural Networks

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“…To solve this issue, we have already developed a novel smart stimulator that consists of a number of LSI-based microchips distributed on a flexible substrate, as shown in figure 1(d) [10][11][12]. Each microchip has several stimulus electrodes, which can be externally controlled to turn on and off through an external control circuit.…”

Section: Introductionmentioning

confidence: 99%

Laboratory investigation of microelectronics-based stimulators for large-scale suprachoroidal transretinal stimulation (STS)

et al. 2007

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This paper describes the technological developments underlying the realization of a reliable and reproducible microchip-based stimulator with a large number of stimulus electrodes. A microchip-based stimulator with over 500 electrodes for suprachoroidal transretinal stimulation (STS) is proposed in this paper, and an example is presented. To enhance reliability and reproducibility for such a large array, we introduce a flip-chip bonding technique and place microchips on the reverse side of a substrate. A square microchip of size 600 microm was fabricated using 0.35 microm standard CMOS process technology. Twelve microchips were flip-chip bonded on a polyimide substrate through Au bumps. To evaluate the feasibility of the proposed device, we successfully fabricated a stimulator with 12 microchips and 118 electrodes made of Pt/Au bumps, and demonstrated their operation in a saline solution for 2 weeks. Also, to evaluate the device operation in vivo, a stimulator with one active IrO(x) electrode was implanted into the scleral pocket of a rabbit and electrical evoked potential (EEP) signals with a threshold of 100 microA were obtained. We also fabricated a simulator with 64 microchips that has 576 electrodes (9 electrodes in a microchip times 64 microchips).

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“…We have been developing LSI-based retinal prosthesis devices taking approach of suprachoroidal transretinal Stimulation (STS) and subretinal stimulation [6][7][8]. Two dimensionally patterned electric stimulation on the remained retinal neural cells is expected to evoke images consists of phosphenes.…”

Section: Introductionmentioning

confidence: 99%

“…However, since Si, material of the LSI device is rigid and a single-chip stimulator device cannot be used for retinal prosthestic applications. To overcome this issue, we have proposed "multi-chip architecture" to configure a thin, flexible retinal stimulation device[6][7][8].…”

mentioning

confidence: 99%

A multi-chip-architecture based flexible stimulation device for retinal prosthesis with a flip-chip packaging technique

Tokuda¹,

Kawada²,

Sugitani³

et al. 2006

2006 International Conference of the IEEE Engineering in Medicine and Biology Society

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In the present work, we designed a multi-chip-architecture based flexible neural stimulation device for retinal prosthesis. Based on the multi-chip architecture, a novel CMOS stimulation device was successfully designed and characterized. A packaging technique for thin, flexible neural stimulation device was also proposed and demonstrated. Flip-chip bonding technology plays an essential role in the fabrication of the present thin and flexible neural stimulation device.

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Micro-sized photo-detecting stimulator array for retinal prosthesis by distributed sensor network approach

Cited by 11 publications

References 23 publications

Si-LSI Based Stimulators for Retinal Prosthesis

Si-LSI Based Stimulators for Retinal Prosthesis

Laboratory investigation of microelectronics-based stimulators for large-scale suprachoroidal transretinal stimulation (STS)

A multi-chip-architecture based flexible stimulation device for retinal prosthesis with a flip-chip packaging technique

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