Micro RNA profiling reveals differentially expressed micro RNA signatures from the skin of patients with nonsegmental vitiligo

The catalase gene promoter and 5ʹ-untranslated region variants lead to altered gene expression and enzyme activity in vitiligo

“…have shown that microRNA (miR)‐147b interacts with the 5ʹ‐UTR of mRNA encoding CAT and can regulate CAT allelic expression imbalance through the SNP in the 5ʹ‐UTR. However, our previous study on skin miR signatures in patients with vitiligo showed no difference in miR‐147b expression . The miR‐147b interaction with the CAT 5ʹ‐UTR rs1049982 was shown to affect regulation of CAT expression in vitro : miR‐147b had a higher binding affinity for the ‘C’ allele than for the ‘T’ allele .…”

Altered expression of four miRNA (miR‐1238‐3p, miR‐202‐3p, miR‐630 and miR‐766‐3p) and their potential targets in peripheral blood from vitiligo patients

“…As a support, another study claimed that there was a correlation between upregulated and downregulated miRNA and the immune imbalance of vitiligo patients . Although a large amount of differentially expressed miRNA have been discovered in vitiligo, only a few targets have been identified and the potential function in BP remains unknown . The identification of miRNA involved in pathogenesis of vitiligo and understanding the miRNA regulation pathways will be vital to the development of miRNA‐based diagnostic and therapeutic strategies for vitiligo.…”

MicroRNA-211 Regulates Oxidative Phosphorylation and Energy Metabolism in Human Vitiligo

“…Recent findings showing (i) abnormal miRNA expression in the skin and serum of patients with vitiligo (Mansuri et al , 2014, Shi et al , 2014, Shi et al , 2013); (ii) miR-211 positively controls pigmentation by targeting Transforming growth factor beta receptor 2 (TGFBR2), a negative regulator of melanogenic enzyme TYR and tyrosinase-related protein-1 ( TYRP1 ) (Dai et al , 2015); (iii) our own recent findings that miR-211 acts as a metabolic switch in non-pigmented melanoma cells (Mazar et al , 2016), and (iv) miR-211-mediated reprogramming of primary fibroblasts triggers elevated expression of proinflammatory genes, cell proliferation, and migration leading to melanoma growth (Dror et al , 2016), prompted us to examine the expression and putative function of miR-211 and its downstream effectors in vitiligo pathogenesis. We reasoned that since miRNAs are known participants in the stress response and autoimmunity in vitiligo, the most highly differentially expressed genes in vitiligo lesions may regulate or be regulated by miRNAs and miR-211 would be represented in the top downregulated transcripts.…”

“…Dysregulated miRNA expression is associated with the pathogenesis of various inflammatory skin disorders such as psoriasis, atopic dermatitis, and allergic contact dermatitis (Sonkoly E et al , 2008), and there is some evidence implicating miRNAs in vitiligo. Gene expression microarray studies have revealed aberrant miRNA expression in the skin and serum of patients with vitiligo (Mansuri et al , 2014, Shi et al , 2014, Shi et al , 2013), with upregulation of miR-224-3p, miR-4712-3p, and miR-3940-5p in peripheral blood mononuclear cells (Wang et al , 2015), miR-25 upregulated in serum (Shi et al , 2016) and miR-99b, miR-125-b, miR-155, and miR-199a-3p upregulated in the skin (Šahmatova et al , 2016) of vitiligo patients. Little is known, however, about the exact role of miRNAs, their targets, and their mechanism of action in the pathophysiology of vitiligo.…”