Micro-RNA (miRNA) profile in Hodgkin lymphoma: association between clinical and pathological variables

Paydaş, Semra; Acikalin, Arbil; Ergïn, Melek; Celik, Hikmet; Yavuz, Basak; Tanrıverdi, Kahraman

doi:10.1007/s12032-016-0749-5

Cited by 63 publications

(60 citation statements)

References 15 publications

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“…miR‐876‐5p is a relatively recently identified miRNA that is deregulated in various human cancers. miR‐876‐5p is one miRNA that is decreased in Hodgkin's lymphoma . In osteosarcoma, decreased miR‐876‐5p expression is positively correlated with advanced clinical stage and poor overall survival rate .…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‐876‐5p represses the cell proliferation and invasion of colorectal cancer through suppressing YAP signalling via targeting RASAL2

Ren

Zhang

Feng

et al. 2020

Clin Exp Pharma Physio

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Aberrant expression of microRNA‐876‐5p (miR‐876‐5p) is implicated in the progression of multiple human cancers. However, the potential role of miR‐876‐5p in colorectal cancer remains poorly understood. The purpose of the current study was to investigate the potential role of miR‐876‐5p in colorectal cancer. miR‐876‐5p expression was significantly downregulated in colorectal cancer tissues and cell lines compared with normal controls. Gain‐of‐function assays revealed that miR‐876‐5p overexpression effectively repressed the malignant behaviours of colorectal cancer cells, including cell proliferation, colony formation, and invasion. Bioinformatics analysis predicted that RAS protein activator like 2 (RASAL2), a potential oncogene for colorectal cancer, is a putative miR‐876‐5p target gene. A luciferase reporter assay confirmed that miR‐876‐5p directly binds to the 3′‐untranslated region (UTR) of RASAL2. Furthermore, both RASAL2 messenger RNA (mRNA) and protein expression were negatively modulated by miR‐876‐5p in colorectal cancer cells. Notably, there was an inverse correlation between miR‐876‐5p and RASAL2 expression in colorectal cancer tissue specimens. Moreover, miR‐876‐5p was involved in regulating the activation of Yes‐associated protein (YAP) signalling through inhibiting RASAL2. However, the miR‐876‐5p‐mediated antitumour effect on colorectal cancer cells was partially reversed by restoring RASAL2 expression. Notably, miR‐876‐5p upregulation impeded the tumour growth of colorectal cancer cells in vivo in nude mice. Overall, these results demonstrated that miR‐876‐5p exerts an antitumour function in colorectal cancer by targeting RASAL2 to suppress YAP signalling activation. These findings highlight the importance of the miR‐876‐5p/RASAL2/YAP axis in colorectal cancer progression and suggest that miR‐876‐5p is a potential therapeutic target for treating colorectal cancer.

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Section: Discussionmentioning

confidence: 99%

MicroRNA‐876‐5p represses the cell proliferation and invasion of colorectal cancer through suppressing YAP signalling via targeting RASAL2

Ren

Zhang

Feng

et al. 2020

Clin Exp Pharma Physio

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“…They reported 11 miRNAs upregulated and 13 downregulated. Two of them showed a correlation with clinic pathological variables; while miR-889 was upregulated in patients with B-symptoms, miR-127-3p was upregulated in NS compared to MC patients [28]. …”

Section: Mirna Signatures In Hl Tissue and Cell Linesmentioning

confidence: 99%

“…Of note, most of the miRNAs identified to date as having clinical or prognostic implications are shared by two or more of the six studies of miRNA signatures in HL [23,24,25,26,27,28] (Figure 1 and Table 1). …”

Section: Mirnas Impacting Prognosis and Treatment Response In Hlmentioning

confidence: 99%

“…They identified 70 gains and 28 losses of miRNA genes in the entire set of patients. Some of these miRNA genes were also deregulated in the different miRNA signatures of HL [23,24,25,26,27,28], including the miR-30 family, miR-124, miR-196a, miR-132, miR-23a, miR-27a, and miR-17-92 clusters [57] (Table 3). …”

Section: Genomic Changes Affecting Mirna Expression In Hlmentioning

confidence: 99%

“…When they combined the results from all the samples (patients and cell lines), they found 308 miRNA genes affected by CNVs in at least three samples-126 amplified and 182 deleted. Among the miRNAs included in the six signatures [23,24,25,26,27,28] (Figure 1B), miR-16, miR-20a, miR-30b, miR-31, and miR-92 can be deregulated by CNVs [58] (Table 3). …”

Section: Genomic Changes Affecting Mirna Expression In Hlmentioning

confidence: 99%

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Non-Coding RNAs in Hodgkin Lymphoma

Cordeiro

Monzó

Navarro

2017

IJMS

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MicroRNAs (miRNAs), small non-coding RNAs that regulate gene expression by binding to the 3’-UTR of their target genes, can act as oncogenes or tumor suppressors. Recently, other types of non-coding RNAs—piwiRNAs and long non-coding RNAs—have also been identified. Hodgkin lymphoma (HL) is a B cell origin disease characterized by the presence of only 1% of tumor cells, known as Hodgkin and Reed-Stenberg (HRS) cells, which interact with the microenvironment to evade apoptosis. Several studies have reported specific miRNA signatures that can differentiate HL lymph nodes from reactive lymph nodes, identify histologic groups within classical HL, and distinguish HRS cells from germinal center B cells. Moreover, some signatures are associated with survival or response to chemotherapy. Most of the miRNAs in the signatures regulate genes related to apoptosis, cell cycle arrest, or signaling pathways. Here we review findings on miRNAs in HL, as well as on other non-coding RNAs.

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