Micro RNA in meniscal ailments: current concepts

Migliorini, Filippo; Vecchio, Gianluca; Giorgino, Riccardo; Eschweiler, Jörg; Hildebrand, Frank; Maffulli, Nicola

doi:10.1093/bmb/ldac039

Cited by 5 publications

(3 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Meniscal tears are common and increase with age [ 41 , 57 ]. Squatting, kneeling, crawling, chair sitting while driving, stair climbing, lifting items, and walking are associated with acute meniscal tears [ 39 , 61 , 79 ]. Both the lateral and medial menisci help preserve the knee biomechanics, and are important for shock absorption, joint stability, joint lubrication, and proprioception [ 6 , 66 , 90 ].…”

Section: Introductionmentioning

confidence: 99%

Meniscectomy is associated with a higher rate of osteoarthritis compared to meniscal repair following acute tears: a meta‐analysis

Migliorini,

Schäfer,

Bell

et al. 2023

Knee surg. sports traumatol. arthrosc.

Self Cite

View full text Add to dashboard Cite

Purpose Meniscal tears are common and may impair knee function and biomechanics. This meta-analysis compared meniscal repair versus resection in patients with symptomatic meniscal tears in terms of patient-reported outcomes measures (PROMs), joint width, surgical failure, and rate of progression to osteoarthritis (OA) at conventional radiography. Methods This study was conducted according to the 2020 PRISMA statement. In August 2023, the following databases were accessed: PubMed, Web of Science, Google Scholar, and Embase. Two reviewers independently performed the analysis and a methodological quality assessment of the included studies. All the clinical investigations which compared repair versus resection of meniscal tears were accessed. Results Data from 20 studies (31,783 patients) were collected. The mean BMI was 28.28 ± 3.2 kg/m2, and the mean age was 37.6 ± 14.0 years. The mean time elapsed from injury to surgery was 12.1 ± 10.2 months and the mean medial joint width was 4.9 ± 0.8 mm. Between studies comparability at baseline was found in age, women, BMI, time from injury to surgery and length of the follow-up, PROMs, medial joint width, and stage of OA. The resection group demonstrated a greater Lysholm score (P = 0.02). No difference was found in the International Knee Documentation Committee (P = 0.2). Nine studies reported data on the rate of failures at a mean of 63.00 ± 24.7 months. No difference was found between the two groups in terms of persistent meniscal symptoms (P = 0.8). Six studies reported data on the rate of progression to total knee arthroplasty at a mean of 48.0 ± 14.7 months follow-up. The repair group evidenced a lower rate of progression to knee arthroplasty (P = 0.0001). Six studies reported data on the rate of advanced knee OA at a mean of 48.0 ± 14.7 months of follow-up. The repair group evidenced a lower rate of advanced knee OA (P = 0.0001). No difference was found in the mean joint space width (P = 0.09). Conclusion Meniscal repair is associated with a lower progression to knee osteoarthritis at approximately six years of follow-up compared to partial meniscectomy. No difference in PROMs, medial joint width, and failures were evidenced. Level of evidence Level III, meta-analysis.

show abstract

Section: Introductionmentioning

confidence: 99%

Meniscectomy is associated with a higher rate of osteoarthritis compared to meniscal repair following acute tears: a meta‐analysis

Migliorini,

Schäfer,

Bell

et al. 2023

Knee surg. sports traumatol. arthrosc.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Structurally, menisci consist predominantly of type I collagen in addition to proteoglycans and elastin [18, 65]. Shock absorption during gait and increasing joint stability are other important functions of the menisci [45]. The lateral and medial menisci differ in shape, percentage of tibial plateau coverage, and load transfer on the medial and lateral compartments during distinct knee movements [30, 34].…”

Section: Introductionmentioning

confidence: 99%

Outside‐in repair technique is effective in traumatic tears of the meniscus in active adults: a systematic review

Migliorini

Pilone

Bell³

et al. 2023

Knee surg. sports traumatol. arthrosc.

Self Cite

View full text Add to dashboard Cite

Purpose Meniscal injuries are common. Outside-in meniscal repair is one of the techniques advocated for the management of traumatic meniscal tears. This systematic review investigated the outcomes of the outside-in repair technique for the management of traumatic tears of the menisci. The outcomes of interest were to investigate whether PROMs improved and to evaluate the rate of complications. Methods Following the 2020 PRISMA statement, in May 2023, PubMed, Web of Science, Google Scholar, and Embase were accessed with no time constraints. All the clinical investigations which reported data on meniscal repair using the outside-in technique were considered for inclusion. Only studies which reported data on acute traumatic meniscal tears in adults were considered. Only studies which reported a minimum of 24 months of follow-up were eligible. Results Data from 458 patients were extracted. 34% (155 of 458) were women. 65% (297 of 458) of tears involved the medial meniscus. The mean operative time was 52.9 ± 13.6 min. Patients returned to their normal activities at 4.8 ± 0.8 months. At a mean of 67-month follow-up, all PROMs of interest improved: Tegner scale (P = 0.003), Lysholm score (P < 0.0001), International Knee Documentation Committee (P < 0.0001). 5.9% (27 of 458) of repairs were considered failures. Four of 186 (2.2%) patients experienced a re-injury, and 5 of 458 (1.1%) patients required re-operation. Conclusion Meniscal repair using the outside-in technique can be effectively performed to improve the quality of life and the activity level of patients with acute meniscal tears. Level of evidence Level IV.

show abstract

“…The meniscus, a fibrocartilaginous structure essential for stabilizing the knee joint, absorbing shocks, distributes forces and protects the articular cartilage [1][2][3][4][5]. Acute tears of the meniscus may be symptomatic, impacting negatively quality of life and sport participation, and may lead to early onset osteoarthritis [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Greater rate of return to play and re-injury following all-inside meniscal repair compared to the inside-out technique: a systematic review

Migliorini

Asparago

Oliva

et al. 2023

Arch Orthop Trauma Surg

Self Cite

View full text Add to dashboard Cite

Introduction Inside-out and all-inside arthroscopic meniscal repairs are widely performed. However, it remains unclear which method promotes greater clinical outcomes. This study compared inside-out versus all-inside arthroscopic meniscal repair in terms of patient-reported outcome measures (PROMs), failures, return to play, and symptoms. Methods This systematic review was conducted in accordance with the PRISMA guidelines. Two authors independently performed the literature search by accessing the following databases: PubMed, Google Scholar, and Scopus in February 2023. All clinical studies which investigated the outcomes of all-inside and/or inside-out meniscal repair were considered. Results Data from 39 studies (1848 patients) were retrieved. The mean follow-up was 36.8 (9 to 120) months. The mean age of the patients was 25.8 ± 7.9 years. 28% (521 of 1848 patients) were women. No difference was found in PROMs: Tegner Activity Scale (P = 0.4), Lysholm score (P = 0.2), and International Knee Document Committee score (P = 0.4) among patients undergoing meniscal repair with all inside or inside-out techniques. All-inside repairs showed a greater rate of re-injury (P = 0.009) but also a greater rate of return to play at the pre-injury level (P = 0.0001). No difference was found in failures (P = 0.7), chronic pain (P = 0.05), reoperation (P = 0.1) between the two techniques. No difference was found in the rate of return to play (P = 0.5) and to daily activities (P = 0.1) between the two techniques. Conclusion Arthroscopic all-inside meniscal repair may be of special interest in patients with a particular interest in a fast return to sport, while, for less demanding patients, the inside-out suture technique may be recommended. High-quality comparative trials are required to validate these results in a clinical setting. Level of Evidence Level III, systematic review.

show abstract

Micro RNA in meniscal ailments: current concepts

Cited by 5 publications

References 39 publications

Meniscectomy is associated with a higher rate of osteoarthritis compared to meniscal repair following acute tears: a meta‐analysis

Meniscectomy is associated with a higher rate of osteoarthritis compared to meniscal repair following acute tears: a meta‐analysis

Outside‐in repair technique is effective in traumatic tears of the meniscus in active adults: a systematic review

Greater rate of return to play and re-injury following all-inside meniscal repair compared to the inside-out technique: a systematic review

Contact Info

Product

Resources

About