Micro-RNA-34a Contributes to the Impaired Function of Bone Marrow-Derived Mononuclear Cells From Patients With Cardiovascular Disease

Qiao, Xu; Seeger, Florian; Castillo, J. De; Iekushi, Kazuma; Boon, Reinier A.; Farcas, Ruxandra; Manavski, Yosif; Li, Yi Gang; Aßmus, Birgit; Zeiher, Andreas M.; Dimmeler, Stefanie

doi:10.1016/j.jacc.2012.02.033

Cited by 82 publications

(64 citation statements)

References 42 publications

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“…93,94 Jakob et al 95 reported that peripheral blood-derived CD34 + stem cells and early outgrowth cells have significantly reduced the levels of proangiogenic miRNA-126 and miR-130a in patients with chronic heart failure caused by ischemic cardiomyopathy as compared with healthy subjects. Other reports in mouse models suggest that cardiac ischemia mobilizes BM mononuclear cells via downregulating the expression of miR-150 activating CXCR4 in BM mononuclear cells.…”

Section: Exosomal Mirnas Reprogramming the Bmmentioning

confidence: 99%

Exosomes and Cardiac Repair After Myocardial Infarction

Sahoo¹,

Losordo

2014

Circulation Research

438

343

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Section: Exosomal Mirnas Reprogramming the Bmmentioning

confidence: 99%

Exosomes and Cardiac Repair After Myocardial Infarction

Sahoo¹,

Losordo

2014

Circulation Research

438

343

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“…Xu et al found that bone marrow cells isolated from MI patients display increased miR-210 and miR-34a levels (148). The latter appears as particularly important for this cell type: inhibition of miR-34 significantly decreases hydrogen peroxideinduced cell death in vitro, whereas its overexpression reduces the bone marrow cell survival.…”

Section: Stem Cells For MI Therapy and Hypoxamirmentioning

confidence: 99%

HypoxamiR Regulation and Function in Ischemic Cardiovascular Diseases

Greco

Gaetano

Martelli

2014

Antioxidants & Redox Signaling

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Significance: MicroRNAs (miRNAs) are deregulated and play a causal role in numerous cardiovascular diseases, including myocardial infarction, coronary artery disease, hypertension, heart failure, stroke, peripheral artery disease, kidney ischemia-reperfusion. Recent Advances: One crucial component of ischemic cardiovascular diseases is represented by hypoxia. Indeed, hypoxia is a powerful stimulus regulating the expression of a specific subset of miRNAs, named hypoxia-induced miRNAs (hypoxamiR). These miRNAs are fundamental regulators of the cell responses to decreased oxygen tension. Certain hypoxamiRs seem to have a particularly pervasive role, such as miR-210 that is virtually induced in all ischemic diseases tested so far. However, its specific function may change according to the physiopathological context. Critical Issues: The discovery of HypoxamiR dates back 6 years. Thus, despite a rapid growth in knowledge and attention, a deeper insight of the molecular mechanisms underpinning hypoxamiR regulation and function is needed. Future Directions: An extended understanding of the function of hypoxamiR in gene regulatory networks associated with cardiovascular diseases will allow the identification of novel molecular mechanisms of disease and indicate the development of innovative therapeutic approaches.

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“…In fact, its overexpression induces senescence in pro-angiogenic cultured endothelial progenitor cells, 41 and promotes cell death in bone marrow-derived pro-angiogenic cells. 42 Mir-34 is induced by p53, even though its levels can also be increased independently of p53. 42, 43 Important miR-34 targets include SIRT1, Bcl-2 and other cell cycle regulators.…”

mentioning

confidence: 96%