Micro-RNA-208a, -208b, and -499 as Biomarkers for Myocardial Damage After Cardiac Surgery in Children

Bolkier, Yoav; Nevo‐Caspi, Yael; Salem, Yasser; Vardi, Amir; Mishali, David; Paret, Gideon

doi:10.1097/pcc.0000000000000644

Cited by 15 publications

(3 citation statements)

References 24 publications

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“…With regard to specific postoperative complications, only a few studies addressing miRNAs as possible biomarkers are available so far: for example, a study investigating 30 children after heart surgery revealed a set of 3 miRNAs (208a, 208b, and 499) as possible biomarkers for early detection of postoperative myocardial damage. 110 Also, miRNA-499 was identified as a marker for postoperative MI in 30 patients undergoing coronary artery bypass grafting. 111 Several ongoing studies are evaluating the suitability of miRNAs as biomarkers in postoperative care, for example, as predictors of postoperative delirium (ClinicalTrials.gov).…”

Section: Mirnas In Anesthesia and Postoperative Carementioning

confidence: 99%

MicroRNAs as Clinical Biomarkers and Therapeutic Tools in Perioperative Medicine

Kreth¹,

Hübner²,

Hinske³

2018

Anesthesia &Amp; Analgesia

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Over the past decade, evolutionarily conserved, noncoding small RNAs-so-called microRNAs (miRNAs)-have emerged as important regulators of virtually all cellular processes. miRNAs influence gene expression by binding to the 3'-untranslated region of protein-coding RNA, leading to its degradation and translational repression. In medicine, miRNAs have been revealed as novel, highly promising biomarkers and as attractive tools and targets for novel therapeutic approaches. miRNAs are currently entering the field of perioperative medicine, and they may open up new perspectives in anesthesia, critical care, and pain medicine. In this review, we provide an overview of the biology of miRNAs and their potential role in human disease. We highlight current paradigms of miRNA-mediated effects in perioperative medicine and provide a survey of miRNA biomarkers in the field known so far. Finally, we provide a perspective on miRNA-based therapeutic opportunities and perspectives.

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Section: Mirnas In Anesthesia and Postoperative Carementioning

confidence: 99%

MicroRNAs as Clinical Biomarkers and Therapeutic Tools in Perioperative Medicine

Kreth¹,

Hübner²,

Hinske³

2018

Anesthesia &Amp; Analgesia

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“…In a study by Bolkier et al, the plasma levels of some cardiac-associated miRNA were dramatically increased after surgery of children undergoing open-heart surgery for CHDs. The increase in the selected miRNAs (microRNA-208a, -208b and -499) correlated with higher troponin levels and delayed hospital discharge [65]. This evidence further justifies the use of circulating miRNAs as biomarkers not only for the diagnosis but also for prognosis and prediction of surgical clinical outcome.…”

Section: Reoxygenation and Reperfusion Injuriesmentioning

confidence: 86%

Hypoxia-Induced Molecular and Cellular Changes in the Congenitally Diseased Heart: Mechanisms and Strategies of Intervention

Iacobazzi¹,

Caputo²,

Ghorbel³

2017

Hypoxia and Human Diseases

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Tissue hypoxia plays a critical role in the pathobiology of congenital heart diseases, especially with regard to cyanotic patients. Here, we describe the cellular and molecular mechanisms induced by hypoxia in the diseased heart, with particular attention to the metabolic and functional changes that underlie the hypoxia-induced right ventricle remodelling. The role of reactive oxygen species in transcriptomic changes, DNA damage, contractile dysfunction and extracellular matrix remodelling will be addressed. Furthermore, the reoxygenation injury, which occurs when oxygen is reintroduced upon initiation of cardiopulmonary bypass, will be discussed. This allows a better understanding of the risks associated with the reoxygenation injury in children undergoing openheart surgery and helps to improve strategies of intervention for myocardial protection.

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“…Contrary to the levels of miR-133 and miR-499, the level of miR-208 positively correlated with cardiac biomarker CK-MB and may be more relevant to cardiac failure, because muscle injures influence the expression of the other two miRNAs [ 88 ]. MiR-208 and miR-499 appear to be promising as factors of myocardial damage after cardiac surgery not only in adults but also in children [ 155 ].…”

Section: Perioperative Prognostic Value Of Mirnasmentioning

confidence: 99%

Diagnostic and Prognostic Value of miRNAs after Coronary Artery Bypass Grafting: A Review

Błażejowska

Urbanowicz

Olasińska-Wiśniewska

et al. 2021

Biology

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MiRNAs are noncoding, 21–24 nucleotide-long RNA particles that control over 60% of genes. MiRNAs affect gene expression through binding to the 3’-untranslated region of messenger RNA (mRNA), thus inhibiting mRNA translation or inducing mRNA degradation. MiRNAs have been associated with various cardiovascular diseases, including heart failure, hypertension, left ventricular hypertrophy, or ischemic heart disease. In addition, miRNA expression alters during coronary artery bypass grafting (CABG) surgery, which could be used to predict perioperative outcomes. CABG is an operation in which complex coronary arteries stenosis is treated by bypassing atherosclerotic lesions with venous or arterial grafts. Despite a very low perioperative mortality rate and excellent long-term survival, CABG is associated with postoperative complications, including reperfusion injury, graft failure, atrial fibrillation and perioperative myocardial infarction. So far, no reliable diagnostic and prognostic tools to predict prognosis after CABG have been developed. Changes in the perioperative miRNA expression levels could improve the diagnosis of post-CABG myocardial infarction and atrial fibrillation and could be used to stratify risk after CABG. Herein, we describe the expression changes of different subtypes of miRNAs during CABG and review the diagnostic and prognostic utility of miRNAs in patients undergoing CABG.

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Micro-RNA-208a, -208b, and -499 as Biomarkers for Myocardial Damage After Cardiac Surgery in Children

Abstract: Circulating micro-RNA-208a, -208b, and -499 are detectable in the plasma of children undergoing cardiac surgery and may serve as novel biomarkers for monitoring and forecasting postoperative myocardial injury and recovery.

Cited by 15 publications

References 24 publications

MicroRNAs as Clinical Biomarkers and Therapeutic Tools in Perioperative Medicine

MicroRNAs as Clinical Biomarkers and Therapeutic Tools in Perioperative Medicine

Hypoxia-Induced Molecular and Cellular Changes in the Congenitally Diseased Heart: Mechanisms and Strategies of Intervention

Diagnostic and Prognostic Value of miRNAs after Coronary Artery Bypass Grafting: A Review

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