Micro RNA 146a gene variant / TNF-α / IL-6 / IL-1 β; A cross-link axis inbetween oxidative stress, endothelial dysfunction and neuro-inflammation in acute ischemic stroke and chronic schizophrenic patients

Ibrahim, Rowida Raafat; Amer, Reham A.; Abozeid, Abeer A.; Elsharaby, Radwa Mahmoud; Shafik, Noha M.

doi:10.1016/j.abb.2019.108193

Cited by 26 publications

(21 citation statements)

References 46 publications

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“…In the study, we found that the association between cIMT and IS and LAA subtype appeared to be strengthened among participants with rs2910164_GG genotype compared with the CC genotype. Of note, C > G polymorphism in pre-miR-146a might down-regulate the expression of mature miR-146a [18,47], therefore providing feedback to induce excess inflammation, which plays an important role in the atherosclerosis and atherothrombotic stroke [45]. The findings from the current study are in line with prior evidence that genetic susceptibility may modify the relations between environmental factors and human health outcomes [48,49].…”

Section: Discussionsupporting

confidence: 85%

“…MiR-146 might be involved in the inflammation process through inhibiting the expression of IRAK-1 and TRAF6, which are key regulators downstream of Toll-like receptor and cytokine signaling pathways [44]. Furthermore, TRAF6 could regulate the expression of pro-inflammatory pathways including NF-κB pathway, MAP kinase pathway, and TNF-α [19,45]. As described in previous studies, endothelial inflammation plays a vital role in the development of atherosclerosis [46].…”

Section: Discussionmentioning

confidence: 88%

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Carotid Intima-Media Thickness, Genetic Risk, and Ischemic Stroke: A Family-Based Study in Rural China

Wang

et al. 2020

IJERPH

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Background: Carotid intima-media thickness (cIMT) has been associated with an elevated risk of ischemic stroke (IS) in several studies, but the results are inconsistent. We investigated whether the association between cIMT and IS varied across different IS subtypes, and further assessed gene–cIMT interactions’ association with IS risk. Methods: A total of 1048 IS cases (795 large-artery atherosclerosis (LAA) cases, 103 small-vessel occlusion (SVO) cases, and 150 other subtypes) and 2696 IS-free controls across 2179 families were included in the analysis. Self-reported IS cases were confirmed through medical records’ review and head imaging by computed tomography and/or magnetic resonance imaging. The mean values of the common cIMT obtained in bilateral distal and proximal carotid artery segments were used. The genotype information of rs2910164 polymorphism in microRNA-146a (miR-146a) was also collected. Results: We found that cIMT was significantly associated with a higher risk of IS and LAA subtype but not SVO subtype in the multivariate-adjusted models. The odds ratio (OR) and 95% confidence interval (CI) in the highest quartile versus the lowest quartile of cIMT was 2.48 (1.92–3.20) for IS and 2.75 (2.08–3.64) for LAA (both p trend <0.001). The results also showed that there was a significant interaction between cIMT and rs2910164 genotype with the risk of IS (p interaction = 0.03) and LAA (p interaction = 0.02). The associations of cIMT with IS and LAA were strengthened among participants carried rs2910164_GG genotype compared with those with rs2910164_CC genotype. Conclusions: Our results indicate that higher cIMT levels were significantly associated with IS and LAA subtype but not SVO subtype, and the relations were modified by rs2910164 polymorphism in miR-146a.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 88%

Carotid Intima-Media Thickness, Genetic Risk, and Ischemic Stroke: A Family-Based Study in Rural China

Wang

et al. 2020

IJERPH

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“…Neuroinflammation is an important marker of the pathology of ischemic stroke, which involves a series of inflammatory responses. Proinflammatory cytokines, TNFα and IL-6, increased significantly during cerebral ischemia and stroke [33,34]. In this study, the experimental results showed that after CIRI, the SOD activity decreased significantly.…”

Section: Discussionsupporting

confidence: 47%

The Effect of Angelica sinensis Polysaccharide on Neuronal Apoptosis in Cerebral Ischemia-Reperfusion Injury via PI3K/AKT Pathway

Xu¹,

Chen

Liu

et al. 2021

International Journal of Polymer Science

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In the present study, the protective effects and mechanism of Angelica sinensis polysaccharide (ASP) were investigated in rats with cerebral ischemia-reperfusion injury (CIRI). Rats were randomly divided into sham group, CIRI group, ASP treatment group, and ASP and LY294002 treatment group. H&E results confirmed the successful induction of CIRI in Sprague-Dawley rats. Compared with the sham group, the neurological function score, percentage of myocardial infarction area, neuronal apoptosis, oxidative stress, and inflammation in the CIRI group were significantly increased. Compared with the CIRI group, the ASP group’s neurological function score, percentage of myocardial infarction area, neuronal apoptosis, oxidative stress, and inflammation were significantly reduced. However, compared with the ASP group, LY294002 inhibited the effect of ASP in CIRI rats. CIRI downregulated the PI3K/AKT pathway and upregulated the apoptosis level. And ASP activated the PI3K/AKT pathway and Bcl-2 protein expression, while it inhibited caspase-3 and Bax expression. LY294002 could significantly inhibit the protective effect of ASP on nerve injury and the expression and phosphorylation of PI3K and Akt protein in CIRI rats. ASP could effectively improve nerve function and nerve cell apoptosis of CIRI rats by activating the PI3K/AKT signaling pathway.

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“…By searching relevant databases, 4,106 articles were identified; after the screening, 3,811 articles were excluded by its title and abstract. Next, 123 articles were further estimated by its contents, in which 110 articles provided data of other polymorphisms, one article conducted by Mir et al ( 2020 ) did not provide the specific lipid levels by the genotypes of rs2910164, one article conducted by Huang et al ( 2015 ) provided lipid levels by the genotypes of rs2910164 but expressed odds ratio (OR) and 95% CI, and 1 article conducted by Ibrahim et al ( 2020 ) provided lipid levels by the genotypes of rs2910164 but in a strange genetic model [(CG + GG) vs. CC]. Therefore, 113 articles were further excluded.…”

Section: Resultsmentioning

confidence: 99%

Associations of the miRNA-146a rs2910164 and the miRNA-499a rs3746444 Polymorphisms With Plasma Lipid Levels: A Meta-Analysis

Liu

Wang

2021

Front. Genet.

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Background: The studies of miRNAs are vibrant and remain at the forefront in the cardiovascular system. Emerging studies indicate that the genetic polymorphisms of the miRNA gene may affect lipid metabolism; this study aims to clarify the specific correlations between the rs2910164 and rs3746444 polymorphisms and lipid levels.Methods and Results: A comprehensive search of literature was performed from December 31, 2020, to May 31, 2021, by searching of the PubMed and the Cochrane databases. The standardized mean difference (SMD) and 95% confidence interval (CI) were used to evaluate the differences in lipid levels between the genotypes. rs2910164, a functional polymorphism in the miRNA-146a gene, was associated with increased triglycerides (TG) (SMD = 0.35, 95% CI = 0.15–0.54, p < 0.001), total cholesterol (TC) (SMD = 0.43, 95% CI = 0.16–0.70, p < 0.001), and low-density lipoprotein cholesterol (LDL-C) (SMD = 0.37, 95% CI = 0.11–0.63, p = 0.01) as well as decreased high-density lipoprotein cholesterol (HDL-C) (SMD = −0.27, 95% CI = −0.47−0.07, p = 0.01) levels. rs3746444, a functional polymorphism in the miRNA-499a gene, was only correlated with decreased TG (SMD = −0.09, 95% CI = −0.17−0.01, P = 0.03) levels.Conclusions: The miRNA-146a rs2910164 polymorphism is significantly associated with atherogenic dyslipidemia.

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Micro RNA 146a gene variant / TNF-α / IL-6 / IL-1 β; A cross-link axis inbetween oxidative stress, endothelial dysfunction and neuro-inflammation in acute ischemic stroke and chronic schizophrenic patients

Cited by 26 publications

References 46 publications

Carotid Intima-Media Thickness, Genetic Risk, and Ischemic Stroke: A Family-Based Study in Rural China

Carotid Intima-Media Thickness, Genetic Risk, and Ischemic Stroke: A Family-Based Study in Rural China

The Effect of Angelica sinensis Polysaccharide on Neuronal Apoptosis in Cerebral Ischemia-Reperfusion Injury via PI3K/AKT Pathway

Associations of the miRNA-146a rs2910164 and the miRNA-499a rs3746444 Polymorphisms With Plasma Lipid Levels: A Meta-Analysis

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