Micro‐Regulators of Hormones and Stress

Sharma, Neha; Mittal, Deepti; Mishra, Neeti‐Sanan

doi:10.1002/9781118889022.ch29

Cited by 7 publications

(2 citation statements)

References 258 publications

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“…Number of computational algorithms or tools are available that allow fast and confident prediction of miRNAs and their targets ( Jones-Rhoades et al, 2006 ). The miRNAs have been implicated in numerous developmental and disease states, but their function in distinct biological pathways and phenotypes remains largely unknown ( Bazzini et al, 2007 ; Sharma et al, 2017 ). Hence, a comprehensive integrome resource of rice miRNA and mRNA would fasten the meta-analysis of miRNA mediated gene regulation in rice at various conditions.…”

Section: Discussionmentioning

confidence: 99%

“…The miRNAs mainly act to down-regulate cognate transcripts in a sequence specific manner. A single miRNA may regulate the expression of many target transcripts and thus acts as a probable master-switch in biological processes related to growth, development and response to environment ( Djami-Tchatchou et al, 2017 ; Sharma et al, 2017 ). In plants, a miRNA gene is transcribed by RNA polymerase II into a primary miRNA transcript which is processed by DCL1 (DICER like 1) protein into a hairpin intermediate, called precursor miRNA (pre-miRNA).…”

Section: Introductionmentioning

confidence: 99%

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ARMOUR – A Rice miRNA: mRNA Interaction Resource

et al. 2018

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ARMOUR was developed as A Rice miRNA:mRNA interaction resource. This informative and interactive database includes the experimentally validated expression profiles of miRNAs under different developmental and abiotic stress conditions across seven Indian rice cultivars. This comprehensive database covers 689 known and 1664 predicted novel miRNAs and their expression profiles in more than 38 different tissues or conditions along with their predicted/known target transcripts. The understanding of miRNA:mRNA interactome in regulation of functional cellular machinery is supported by the sequence information of the mature and hairpin structures. ARMOUR provides flexibility to users in querying the database using multiple ways like known gene identifiers, gene ontology identifiers, KEGG identifiers and also allows on the fly fold change analysis and sequence search query with inbuilt BLAST algorithm. ARMOUR database provides a cohesive platform for novel and mature miRNAs and their expression in different experimental conditions and allows searching for their interacting mRNA targets, GO annotation and their involvement in various biological pathways. The ARMOUR database includes a provision for adding more experimental data from users, with an aim to develop it as a platform for sharing and comparing experimental data contributed by research groups working on rice.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%