Micro reactors: principles and applications in organic synthesis

Fletcher, Paul D. I.; Haswell, Stephen J.; Pombo‐Villar, Esteban; Warrington, Brian H.; Watts, Paul; Wong, Stephanie Y. F.; Zhang, Xunli

doi:10.1016/s0040-4020(02)00432-5

Cited by 453 publications

(248 citation statements)

References 58 publications

(48 reference statements)

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“…Microfluidic devices have been fabricated from a range of different materials including polymers, 38 glass, 39 silicon, 40 metals, 4 and ceramics. 20 The selection of material is based on the chemistry required, the operating conditions for the reaction, as well as the ease of manufacture of the part.…”

Section: Microfluidic Devices and Manufacturing Methodsmentioning

confidence: 99%

Design and additive manufacture for flow chemistry

et al. 2013

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Section: Microfluidic Devices and Manufacturing Methodsmentioning

confidence: 99%

Design and additive manufacture for flow chemistry

et al. 2013

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“…[171] Since the first use of MF to prepare Cd nanoparticles on a lab-on-a-chip device, [172] advancement in the area of chemical synthesis of nanomaterials has been accelerated over the past decade. [39] Since then, various nanoparticles such as metal, [173] metal oxide, [174] semiconductors, [175] organic, [176] inorganic, etc., have been synthesized in MF systems, for example CdSe, Cds, Ti 2 O, boehmite, Au, Co, Ag, Pd, Cu, BaSO 4 , and CdSe − ZnS core-shell nanoparticles. [177] In nearly all cases MF synthesis has demonstrated clear advantages over conventional batch methods in terms of monodispersity and shape control.…”

Section: Microfluidic Synthesis Of Nanoparticlesmentioning

confidence: 99%

“…[175,200] Furthermore, by eliminating the need to store and transport potentially hazardous materials, flexibility for tailoring complex functional nanomaterials is provided. [201] h. Easy Scale out:…”

Section: F Continuous Synthesismentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

192

171

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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“…[1][2][3][4][5] One of the main drivers behind such work lies in the fact that when micrometer-scale fluidic channels are used, they have a high surface-tovolume ratio compared with more conventional (Ͼ1 cm) vessels. As an analogy, when the dimension of a cube is reduced from 1 mm to 1 µm, the surface-to-volume ratio increases by a factor of a thousand.…”

Section: Introductionmentioning

confidence: 99%

“…When performing chemical reactions in non-aqueous solvent systems, glass has proved to be an excellent choice of substrate due to its chemical and thermal resistance and its optical transparency, which enables on-chip detection to be carried out with relative ease. 2,4 In addition, the presence of inherent native surface charges makes glass most suitable for supporting electro-osmotic flow. 4 This surface property is also present in a number of polymer materials such as poly(dimethylsiloxane) (PDMS), an elastomeric and optically transparent polymer, which has proven to be a popular material for its low cost and fast prototyping.…”

Section: Introductionmentioning

confidence: 99%

Materials Matter in Microfluidic Devices

Zhang¹,

Haswell²

2006

MRS Bull.

Self Cite

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A number of materials, including silicon, quartz, glass, metal, and polymers, have been used to date to fabricate mi- MRS BULLETIN • VOLUME 31 • FEBRUARY 2006 95 Materials Matter in Microfluidic DevicesXunli Zhang and Stephen J. Haswell AbstractAs more micro-and nanofluidic methodologies are developed for a growing number of diverse applications, it becomes increasingly apparent that the choice of substrate material can have a profound effect on the eventual performance of a device. This is due mostly to the high surface-to-volume ratio that exists within such small structures. In addition to the obvious limitations related to the choice of solvent, operating temperatures, and pressure, the method of fluidic pumping-in particular, an electrokinetics-based methodology using a combination of electro-osmotic and electrophoresis flows-can further complicate material choice. These factors, however, are only part of the problem; once chemicals or biological materials (e.g., proteins or cells) are introduced into a microfluidic system, surface characteristics will have a profound influence on the activity of such components, which will subsequently influence their performance. This article reviews the common types of materials that are currently used to fabricate microfluidic devices and considers how these materials may influence the overall performance associated with chemical and biological processing. Consideration will also be given to the selection of materials and surface modifications that can aid in exploiting the high surface properties to enhance process performance.

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Micro reactors: principles and applications in organic synthesis

Cited by 453 publications

References 58 publications

Design and additive manufacture for flow chemistry

Design and additive manufacture for flow chemistry

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Materials Matter in Microfluidic Devices

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