Micro particle-image velocimetry of bead suspensions and blood flows

In this work we combined numerical simulation with molecular-diffusion effect, high-tempo micro-particle image velocimetry (l-PIV), and probability distribution function (PDF) analysis to investigate the chaotic mixing and hydrodynamics inside a droplet moving through a planar serpentine micromixer (PSM). Robust solutions for the distributions of interface and concentration of the droplets were obtained via computational fluid dynamics. The simulated fluid patterns are consistent with those measured with l-PIV, which serves as a powerful nonintrusive diagnostic approach to observe the droplets. Two mechanisms are proposed to enhance the performance of mixing in a PSMthe deformation of droplets and the asymmetric recirculation within the droplets. On introducing alternating cross sections into a winding channel, this specific design of PSM is found to amplify the fluid disturbance and maximum vorticity difference. Data show that the PDF of the vorticity fields is modified and the fraction with larger vorticity is increased. Accordingly, the PSM is capable of achieving a mixing index 90% within 700 lm (Re = 2), which is eight times better than for a straight microchannel. The results not only demonstrate explicitly the fluid patterns within the droplets but also provide significant insight into the factors dominating the mixing efficiency.

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“…The apparatus for l-PIV, which is similar to that used by Bitsch et al (2005), is sketched in Fig. 3.…”

Section: Apparatus For L-pivmentioning

confidence: 99%

Mixing and hydrodynamic analysis of a droplet in a planar serpentine micromixer

Tung

Yang

2009

Microfluid Nanofluid

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“…However, later they measured both tracer particles and RBCs through a 100 μm glass capillary and they reported that by using in vitro blood with about 20% Hct the velocity profiles were parabolic (Sugii et al, 2005). By using a microchannel close to a rectangular shape, Bitsch and his co-workers (Bitsch et al, 2005) have reported blunt profiles. More recently, by using liposomes tracer particles the bloodplasma velocity was measured in the beating heart of a chicken embryo (Vennemann et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

In Vitro Blood Flow Behaviour in Microchannels with Simple and Complex Geometries

Garcia¹,

Dias²,

Lima³

2012

Applied Biological Engineering - Principles and Practice

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“…As a result, this combination, known as a micro-PIV, has greatly increased the resolution of conventional PIV. Because of the success of the micro-PIV in measuring accurate velocity fields of homogeneous fluids in microfluidic devices (Nguyen & Wereley 2002), the technique has been recently used to investigate blood flow behaviour in both microchannels and microvessels (Nakano et al 2003, Bitsch et al 2005, Vennemann P. et al 2006.…”

Section: Introductionmentioning

confidence: 99%