Micro-particle corrugation, adhesion and inhalation aerosol efficiency

Adi, Santoso; Adi, Handoko; Tang, Patricia A.; Traini, Daniela; Chan, Hak‐Kim; Young, Paul M.

doi:10.1016/j.ejps.2008.05.009

Cited by 87 publications

(35 citation statements)

References 22 publications

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“…The ratio of tap to bulk density, also known as Hausner ratio, reflects the flowability of particles, which is closely related to the interparticle interactions, and the lower the Hausner ratio values, the less cohesive the particles are (28,29). Therefore, it could be deduced that corrugated particles had lower the interparticulate interactions than moderately corrugated or smooth particles, and such findings were in well agreement with previous results (13)(14)(15)(16)30).…”

Section: Physical Characteristics Of Spray-dried Particlessupporting

confidence: 81%

“…In contrast, irregular surface particles improve dispersibility by decreasing cohesive and adhesive interaction strength arising from reducing contact surface area. Typical examples of irregular surface particles include corrugated (also called raisin-like or wrinkled) particles and the use of corrugated particles in drug alone or drug-carrier DPI system has been successfully demonstrated to improve aerosol performance of spray-dried bovine serum albumin (BSA) and gentamicin (13)(14)(15)(16)(17). Relative to regular particles, irregular surface particles have increased surface roughness.…”

Section: Introductionmentioning

confidence: 99%

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Preparation and In Vitro Aerosol Performance of Spray-Dried Shuang-Huang-Lian Corrugated Particles in Carrier-Based Dry Powder Inhalers

et al. 2012

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Abstract. The development of dry powder inhalation (DPI) products of traditional Chinese medicine (TCM) remains to be a challenge due to chemical complexity and batch-to-batch variations in constituent composition. This study was to investigate the feasibility of using spray-dried corrugated particles to improve the aerodynamic performance of a TCM, Shuang-Huang-Lian (SHL), in carrier-based DPI. Particles with different surface roughness were spray-dried by the addition of leucine and concomitant manipulation of spray-drying parameters. The surface roughness was determined by atomic force microscopy, whilst the aerodynamic performance of drug particle-mannitol/lactose blends was evaluated using a next-generation pharmaceutical impactor through a Cyclohaler. Although the emission efficiency for corrugated particle-based DPI was ∼10% lower than that for smooth SHL, the fine particle fractions (FPF <4.4 μm ) of 32.4-36.8% for the former were significantly higher than those of 14.7-16.2% for the latter. In particular, the FPF and fraction of drug detached from the carrier appeared not to be significantly affected by the variation in constituent composition of SHL. This study demonstrates that the use of corrugated particles in carrier-based DPI improved aerosol performance by facilitating drug detachment from the carrier, independent of variation in constituent composition, and such particles were potentially applicable to the development of SHL DPI products.

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Section: Physical Characteristics Of Spray-dried Particlessupporting

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Preparation and In Vitro Aerosol Performance of Spray-Dried Shuang-Huang-Lian Corrugated Particles in Carrier-Based Dry Powder Inhalers

et al. 2012

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“…Since micro-particle corrugation, adhesion and surface morphology can greatly affect the inhalation aerosol efficiency, this model might not be beneficial enough for particle-phase contaminants, but vapor phase (Adi et al, 2008). Furthermore, this study is based on the assumption that the 6-year PM data is adequate for evaluating life time exposure of general population.…”

Section: Three-dimensional Plots Of Principal Component Analysis (Pca)mentioning

confidence: 99%

Hospital out-and-in-patients as Functions of Trace Gaseous Species and Other Meteorological Parameters in Chiang-Mai, Thailand

Pongpiachan

Paowa

2015

Aerosol Air Qual. Res.

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The aims of this study were to investigate the impact of meteorological parameters and trace gas concentrations on daily hospital walk-ins and admissions in Chiang-Mai province, Thailand, during 2007Thailand, during -2013. Advanced statistical models, including t-tests, Analysis of Variance (ANOVA), Multiple Linear Regression Analysis (MLRA) and Incremental Lifetime Particulate Matter Exposure (ILPE), were constructed using meteorological data from the Pollution Control Department (PCD), Ministry of Natural Resources and Environment (MNRE), Thailand, and the Thai Meteorological Department at Chiang-Mai Province Air Quality Observatory Site (TMCS) as well as the number of walk-in and admitted patients at Nakornping Hospital, Chiang-Mai (NHCM). The results showed that all trace gaseous species and PM 10 were significantly higher during the "haze episode" than during the "non-haze period." The FTIR spectra highlight the relatively homogeneous organic functional compositions of PM 2.5 collected from urban, suburban and rural observatory sites, indicating that agricultural waste burning plays an important role in air quality during the "haze episode." The effect of age on susceptibility to respiratory diseases was investigated by separating the dataset into four groups (i.e., < 15 years, 15-59 years, 60-74 years and ≥ 75 years). The ANOVA results revealed a significant increase in hospital walk-ins and admissions for both genders in the < 15 years group (p < 0.005). MLRA revealed the significantly highest impacts of CO on hospital walk-ins for both genders. The predicted ILPE of PM 10 showed the highest values for both genders during the "haze-episode" in 2007, with average values of 3.338 ± 0.576 g and 1.838 ± 0.317 g for male and female outdoor workers, respectively, over an exposure duration of 25 years.

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“…It is well documented that the particle size, size distribution (4), morphology (33,34), surface roughness (23,35), surface area, flowability (6), density, and surface energy (7) of lactose carriers all have influence on the DPI formulations. The granulated lactose carrier particles produced in this study had similar solid-state, flowability, surface area, and true density, but different size, morphology, roughness, and bulk/tap density.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Granulated Lactose as a Carrier for DPI Formulations 1: Effect of Granule Size

2014

AAPS PharmSciTech

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ABSTRACT. The objective of this study was to investigate the effect of large granulated lactose carrier particle systems on aerosol performance of dry powder inhaler formulations. Granulated lactose carriers with average sizes ranging from 200 to 1,000 μm were prepared and subsequently fractionated into separate narrow size powders. The fractionated granulated lactose (GL) samples were characterized in terms of size, specific surface area, surface roughness, morphology, density, flowability, and solid-state. The in vitro aerosolization performance was performed on the different size fractions of GL samples from a commercial inhaler device (Aerolizer®) with a model formulation (2% w/w salbutamol sulfate). The cascade impaction parameters employed were 60 or 90 L/min with standard (aperture size, 0.6 mm) or modified piercing holes (aperture size, 1.2 mm) of the inhaler loaded capsules. It was shown that the largest size fraction formulation (850-1000 μm) had a slight improvement in the fine particle fraction (FPF) compared to immediately preceding size fractions, explained by a smaller adhesive force between drug and carrier. Compared to commercial piercing holes, enlarged piercing holes generated a slight decreasing trend of FPF as the lactose powder sizes increased from 200-250 μm to 600-850 μm, perhaps due to the reduced detachment force by flow forces. The size, surface roughness, density, and flowability of lactose carrier as well as device design all contributed to the aerosol dispersion performance of granulated lactose-based adhesive mixtures. It was concluded that poorer or enhanced redispersion performance is not an inherent property to the significantly large size of granulated lactose carriers as previously contended.

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Micro-particle corrugation, adhesion and inhalation aerosol efficiency

Cited by 87 publications

References 22 publications

Preparation and In Vitro Aerosol Performance of Spray-Dried Shuang-Huang-Lian Corrugated Particles in Carrier-Based Dry Powder Inhalers

Preparation and In Vitro Aerosol Performance of Spray-Dried Shuang-Huang-Lian Corrugated Particles in Carrier-Based Dry Powder Inhalers

Hospital out-and-in-patients as Functions of Trace Gaseous Species and Other Meteorological Parameters in Chiang-Mai, Thailand

Evaluation of Granulated Lactose as a Carrier for DPI Formulations 1: Effect of Granule Size

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