Micro-needles as an effective drug delivery system and associated patents in pharmaceutical field: A Review

Abstract

Microneedles (MNs) are the most interesting and minimally invasive technique in pharmaceutical drug delivery systems. Recently researchers have concluded that MNs can be prominent future methods. Depending on the unique properties of MNs, they can be used widely in drug delivery systems. This delivery method has improved drug delivery avoiding many hurdles that were linked with the conventional system. The principal mechanism involved is temporarily damaging the skin layer; hence micron-size pores are created, which help the drug to reach the targeted site without any complications. The popularity of MNs in pharmaceutical and biomedical research is growing exponentially as it offers easy delivery of bio-actives to the specific site with minimal invasion. Several numbers of molecules are delivering via MNs, such as hormones, vaccines, and peptides. In this review, the efficiency of Micro-needle, their fabrication materials, as drug delivery carriers, and various associated patents are discussed.

Concept for a Unidirectional Release Mucoadhesive Buccal Tablet for Oral Delivery of Antidiabetic Peptide Drugs Such as Insulin, Glucagon-like Peptide 1 (GLP-1), and their Analogs

“…Moreover, the development of new formulation technologies, such as spray drying and freeze drying, has enabled the production of stable and easily administered oral peptide drug formulations [ 18 , 29 ]. Furthermore, advances in nanotechnology and biotechnology have allowed for the design of novel drug delivery systems, such as implantable devices and micro-needles, that could provide a sustained release of peptide drugs and eliminate the need for frequent dosing [ 30 , 31 ]. These innovations offer hope for the development of effective and convenient oral peptide drugs for diabetes mellitus therapy.…”