Micro/Nano Technologies for High-Density Retinal Implant

Zeng, Qi; Zhao, Siqi; Yang, Hangao; Zhang, Yi; Wu, Tianzhun

doi:10.3390/mi10060419

Cited by 27 publications

(19 citation statements)

References 130 publications

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“…It seems that this layer-by-layer strategy was more sophisticated for implantable TENG devices. A similar approach using parylene-C/Al 2 O 3 achieved an excellent hermetical level, up to 10 −10 Pa·m/s, for a 10-year implant which met the Food and Drug Administration (FDA) medical standard [ 81 ].…”

Section: The Development Of Teng-based Self-powered Nerve Stimulatmentioning

confidence: 99%

A Review and Perspective for the Development of Triboelectric Nanogenerator (TENG)-Based Self-Powered Neuroprosthetics

Wang

Zeng

et al. 2020

Micromachines

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Neuroprosthetics have become a powerful toolkit for clinical interventions of various diseases that affect the central nervous or peripheral nervous systems, such as deep brain stimulation (DBS), functional electrical stimulation (FES), and vagus nerve stimulation (VNS), by electrically stimulating different neuronal structures. To prolong the lifetime of implanted devices, researchers have developed power sources with different approaches. Among them, the triboelectric nanogenerator (TENG) is the only one to achieve direct nerve stimulations, showing great potential in the realization of a self-powered neuroprosthetic system in the future. In this review, the current development and progress of the TENG-based stimulation of various kinds of nervous systems are systematically summarized. Then, based on the requirements of the neuroprosthetic system in a real application and the development of current techniques, a perspective of a more sophisticated neuroprosthetic system is proposed, which includes components of a thin-film TENG device with a biocompatible package, an amplification circuit to enhance the output, and a self-powered high-frequency switch to generate high-frequency current pulses for nerve stimulations. Then, we review and evaluate the recent development and progress of each part.

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Section: The Development Of Teng-based Self-powered Nerve Stimulatmentioning

confidence: 99%

A Review and Perspective for the Development of Triboelectric Nanogenerator (TENG)-Based Self-Powered Neuroprosthetics

Wang

Zeng

et al. 2020

Micromachines

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“…Although this does not give a high-quality image, it does allow a blind person sufficient image quality to function and navigate around objects. This work has shown the feasibility of the approach, and work is continuing to improve the image quality [ 76 , 77 ], including increasing the area of the electrode array and increasing the density of electrodes [ 78 , 79 ]. Another approach is to implant arrays of the probe directly into the optical cortex at the back of the brain [ 80 ].…”

Section: Long Term Implantsmentioning

confidence: 99%

In-Vivo Microsystems: A Review

French

2020

Sensors

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In-vivo sensors yield valuable medical information by measuring directly on the living tissue of a patient. These devices can be surface or implant devices. Electrical activity in the body, from organs or muscles can be measured using surface electrodes. For short term internal devices, catheters are used. These include cardiac catheter (in blood vessels) and bladder catheters. Due to the size and shape of the catheters, silicon devices provided an excellent solution for sensors. Since many cardiac catheters are disposable, the high volume has led to lower prices of the silicon sensors. Many catheters use a single sensor, but silicon offers the opportunity to have multi sensors in a single catheter, while maintaining small size. The cardiac catheter is usually inserted for a maximum of 72 h. Some devices may be used for a short-to-medium period to monitor parameters after an operation or injury (1–4 weeks). Increasingly, sensing, and actuating, devices are being applied to longer term implants for monitoring a range of parameters for chronic conditions. Devices for longer term implantation presented additional challenges due to the harshness of the environment and the stricter regulations for biocompatibility and safety. This paper will examine the three main areas of application for in-vivo devices: surface devices and short/medium-term and long-term implants. The issues of biocompatibility and safety will be discussed.

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“…Advances in micro-fabrication technology, electronics, materials, surgical techniques, and other research have enabled our Bionic Eye Technologies team (formerly known as the Boston Retinal Implant Project or BRIP) to build a 256+ channel retinal prosthesis to restore vision to patients who have lost vision due to degenerative diseases such as retinitis pigmentosa and age-related macular degeneration [ 5 ]. In recent years, the visual prosthetic community of researchers and commercial entities has expanded to well over 20 groups worldwide [ 4 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ]. Remarkable strides have been made toward the restoration of useful vision to severely blind patients by several teams, including recent promising results by the Pixium company in subjects with macular degeneration [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Micro-Fabrication of Components for a High-Density Sub-Retinal Visual Prosthesis

Shire¹,

Gingerich²,

Wong³

et al. 2020

Micromachines

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We present a retrospective of unique micro-fabrication problems and solutions that were encountered through over 10 years of retinal prosthesis product development, first for the Boston Retinal Implant Project initiated at the Massachusetts Institute of Technology and at Harvard Medical School’s teaching hospital, the Massachusetts Eye and Ear—and later at the startup company Bionic Eye Technologies, by some of the same personnel. These efforts culminated in the fabrication and assembly of 256+ channel visual prosthesis devices having flexible multi-electrode arrays that were successfully implanted sub-retinally in mini-pig animal models as part of our pre-clinical testing program. We report on the processing of the flexible multi-layered, planar and penetrating high-density electrode arrays, surgical tools for sub-retinal implantation, and other parts such as coil supports that facilitated the implantation of the peri-ocular device components. We begin with an overview of the implantable portion of our visual prosthesis system design, and describe in detail the micro-fabrication methods for creating the parts of our system that were assembled outside of our hermetically-sealed electronics package. We also note the unique surgical challenges that sub-retinal implantation of our micro-fabricated components presented, and how some of those issues were addressed through design, materials selection, and fabrication approaches.

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Micro/Nano Technologies for High-Density Retinal Implant

Cited by 27 publications

References 130 publications

A Review and Perspective for the Development of Triboelectric Nanogenerator (TENG)-Based Self-Powered Neuroprosthetics

A Review and Perspective for the Development of Triboelectric Nanogenerator (TENG)-Based Self-Powered Neuroprosthetics

In-Vivo Microsystems: A Review

Micro-Fabrication of Components for a High-Density Sub-Retinal Visual Prosthesis

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