Micro-mixing in flow-type process for supercritical CO2 extraction of ferulic acid and gallic acid from aqueous solution

Houng, Peany; Murakami, Y.; Shimoyama, Yusuke

doi:10.1016/j.jcou.2021.101503

Cited by 9 publications

(10 citation statements)

References 41 publications

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“…Swirlflow mixing was generated in the mixing chamber by the eccentric connection between two sub-flow channels and the main-flow channel. 23 The inner diameter of the microchannel used in the process was set to 0.5 mm. The sample of emulsion was collected from a separated output of emulsion line for analysis.…”

Section: Methodsmentioning

confidence: 99%

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Integrated Micro-flow Process of Emulsification and Supercritical Fluid Emulsion Extraction for Stearic Acid Nanoparticle Production

Wijakmatee

Shimoyama

Orita

2022

Ind. Eng. Chem. Res.

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Combination of micro-flow processes between emulsification and supercritical fluid emulsion extraction was applied for the fabrication of stearic acid lipid nanoparticles dispersed in aqueous solution. Controllability of the lipid nanoparticle production by the flow rate of oil and water phases, surfactant species, surfactant concentrations, and pressure was investigated. The utilization of two different surfactant species was considered for the stabilization of oil droplets and solid lipid nanoparticles in water. As a result, Tween 80, a hydrophilic surfactant, was revealed to have an important role in obtaining a homogeneous emulsion phase, which is necessary to control particle sizes after the extraction process. Additionally, lecithin, a hydrophobic surfactant, successfully narrowed the size distribution of solid lipid nanoparticles, which can be explained by the suppression of their aggregation. Furthermore, the extraction efficiency values were over 97% and the model active ingredient was successfully encapsulated in the particle structure. These results suggest that combination of surfactant systems in the integrated micro-flow process is an appealing approach to continuously fabricate stable and uniform solid lipid nanoparticles for practical applications.

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Section: Methodsmentioning

confidence: 99%

“…: 0.5 mm). Swirl-flow mixing was generated in the mixing chamber by the eccentric connection between two sub-flow channels and the main-flow channel . The inner diameter of the microchannel used in the process was set to 0.5 mm.…”

Section: Methodsmentioning

confidence: 99%

Integrated Micro-flow Process of Emulsification and Supercritical Fluid Emulsion Extraction for Stearic Acid Nanoparticle Production

Wijakmatee

Shimoyama

Orita

2022

Ind. Eng. Chem. Res.

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“…In general, the GA is generated by hydrolysis of tannic acid‐based compounds, which may produce toxic wastewater and pollute the environmental. The commonly extraction methods for GA include reflux extraction, ultrasonic extraction and supercritical CO 2 fluid extraction, and so forth 9–11 . However, the low extraction efficiency, large solvent consumption, and the stringent requirements on their instruments limit the practical applications.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of molecularly imprinted polymer based on cooperative imprinting for enrichment of gallic acid in Puer tea

Zhang

Zhu

Guo

et al. 2023

J of Applied Polymer Sci

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The molecularly imprinted polymer (MIP) for gallic acid (GA) was prepared based on the cooperative imprinting of boronate affinity interactions and hydrogen bond. The fabricated MIP were designed by the polymerization of template with co-functional monomer, 3-acrylamidophenylboronic acid (AAPBA) and methacrylic acid (MAA). The characteristics of the resulting polymer (AAPBA-co-MAA MIP) were tested by scanning electron microscope (SEM), Fourier transform infrared spectra (FTIR) and nitrogen adsorption-desorption. Bonding performance demonstrated that the AAPBA-co-MAA MIP possessed the excellent recognition ability in the incubation solution with pH 7.4 and presented higher adsorption capacity, faster adsorption rate and satisfactory selectivity for GA. Additionally, the AAPBA-co-MAA MIP revealed the good applications in the separation and enrichment of GA from Puer tea, and the amount of GA enriched by them was determined to be 2.75 mg g À1 . This work suggested that the integration of cooperative imprinting strategy between covalent and non-covalent would be an effective way to improve the specific recognition performance of the MIP.

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“…The traditional methods for extracting GA mainly include solvent extraction [ 7 ], solid-phase extraction [ 8 ], ultrasonic-assisted extraction [ 9 ], supercritical fluid extraction [ 10 , 11 ], and many other techniques. The traditional methods for extracting GA are time-consuming and labor-intensive.…”

Section: Introductionmentioning

confidence: 99%

Selective Recognition of Gallic Acid Using Hollow Magnetic Molecularly Imprinted Polymers with Double Imprinting Surfaces

Zhou

Yan

et al. 2022

Polymers

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Gallic acid is widely used in the field of food and medicine due to its diversified bioactivities. The extraction method with higher specificity and efficiency is the key to separate and purify gallic acid from complex biological matrix. Herein, using self-made core-shell magnetic molecularly imprinted polymers (MMIP) with gallic acid as template, a hollow magnetic molecularly imprinted polymer (HMMIP) with double imprinting/adsorption surfaces was prepared by etching the mesoporous silica intermediate layer of MMIP. The characterization and adsorption research showed that the HMMIP had larger specific surface area, higher magnetic response strength and a more stable structure, and the selectivity and saturated adsorption capacity (2.815 mmol/g at 318 K) of gallic acid on HMMIP were better than those of MMIP. Thus, in addition to MMIP, the improved HMMIP had excellent separation and purification ability to selectively extract gallic acid from complex matrix with higher specificity and efficiency.

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Micro-mixing in flow-type process for supercritical CO2 extraction of ferulic acid and gallic acid from aqueous solution

Cited by 9 publications

References 41 publications

Integrated Micro-flow Process of Emulsification and Supercritical Fluid Emulsion Extraction for Stearic Acid Nanoparticle Production

Integrated Micro-flow Process of Emulsification and Supercritical Fluid Emulsion Extraction for Stearic Acid Nanoparticle Production

Synthesis of molecularly imprinted polymer based on cooperative imprinting for enrichment of gallic acid in Puer tea

Selective Recognition of Gallic Acid Using Hollow Magnetic Molecularly Imprinted Polymers with Double Imprinting Surfaces

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