Micro-hydroxyapatite reinforced Ti-based composite with tailored characteristics to minimize stress-shielding impact in bio-implant applications

Kumar, Rakesh; Agrawal, Anupam

doi:10.1016/j.jmbbm.2023.105852

Cited by 9 publications

(2 citation statements)

References 40 publications

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“…To combat this, researchers are attempting to enhance the mechanical properties of CP Ti, including its strength, ductility, and fatigue resistance [ 4 , 8 , 9 , 10 , 11 ]. In addition, improving biocompatibility is crucial, which can be achieved through surface modification [ 12 , 13 , 14 ] or by tailoring the composition with bioactive elements, such as calcium, phosphorus, and oxygen [ 15 , 16 , 17 , 18 ]. Therefore, improving the mechanical properties and biocompatibility of CP Ti through continuous research is essential for the development of safe and effective biomedical implants.…”

Section: Introductionmentioning

confidence: 99%

Improving Pure Titanium’s Biological and Mechanical Characteristics through ECAP and Micro-Arc Oxidation Processes

Alemayehu,

Todoh,

Hsieh

et al. 2023

Micromachines

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Pure titanium is limited to be used in biomedical applications due to its lower mechanical strength compared to its alloy counterpart. To enhance its properties and improve medical implants feasibility, advancements in titanium processing technologies are necessary. One such technique is equal-channel angular pressing (ECAP) for its severe plastic deformation (SPD). This study aims to surface modify commercially pure titanium using micro-arc oxidation (MAO) or plasma electrolytic oxidation (PEO) technologies, and mineral solutions containing Ca and P. The composition, metallography, and shape of the changed surface were characterized using X-ray diffraction (XRD), digital optical microscopy (OM), and scanning electron microscope (SEM), respectively. A microhardness test is conducted to assess each sample’s mechanical strength. The weight % of Ca and P in the coating was determined using energy dispersive spectroscopy (EDS), and the corrosion resistance was evaluated through potentiodynamic measurement. The behavior of human dental pulp cell and periodontal cell behavior was also studied through a biomedical experiment over a period of 1-, 3-, and 7-days using culture medium, and the cell death and viability can be inferred with the help of enzyme-linked immunosorbent assay (ELISA) since it can detect proteins or biomarkers secreted by cells undergoing apoptosis or necrosis. This study shows that the mechanical grain refinement method and surface modification might improve the mechanical and biomechanical properties of commercially pure (CP) titanium. According to the results of the corrosion loss measurements, 2PassMAO had the lowest corrosion rate, which is determined to be 0.495 mmpy. The electrode potentials for the 1-pass and 2-pass coated samples are 1.44 V and 1.47 V, respectively. This suggests that the coating is highly effective in reducing the corrosion rate of the metallic CP Ti sample. Changes in the grain size and the presence of a high number of grain boundaries have a significant impact on the corrosion resistance of CP Ti. For ECAPED and surface-modified titanium samples in a 3.6% NaCl electrolyte solution, electrochemical impedance spectroscopy (EIS) properties are similar to Nyquist and Bode plot fitting. In light of ISO 10993-5 guidelines for assessing in vitro cytotoxicity, this study contributes valuable insights into pulp and periodontal cell behavior, focusing specifically on material cytotoxicity, a critical factor determined by a 30% decrease in cell viability.

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Section: Introductionmentioning

confidence: 99%

Improving Pure Titanium’s Biological and Mechanical Characteristics through ECAP and Micro-Arc Oxidation Processes

Alemayehu,

Todoh,

Hsieh

et al. 2023

Micromachines

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“…Composite biomaterials that are slightly resorbable, nonresorbable, and completely resorbable are additional classifications of avital composites. − The nonresorbable combinations are not meant to break down within the tissue’s surroundings . Extended use of implants including substitutions of joints, bone grafts, spinal tubes, plates, orthodontic care, tendons, and ligaments show the most promise for them. − A particular type of thermally and mechanically stable polymer used in composite fabrication is an unsaturated polyester resin, which mostly contains unsaturated double bonds and ester bonds through a polycondensation reaction involving unsaturated dicarboxylic acid and either saturated dicarboxylic acid or unsaturated diol. , An “unsaturated polyester resin (UPR)″ is frequently reinforced with fiber materials for employment as composites. Polyesters that contain either unsaturated dicarboxylic acid and anhydride (often maleic anhydride) or saturated dicarboxylic acid and anhydride (usually phthalic anhydride) are referred to as unsaturated polyesters. , When two organic acid components combine with one or more alcohols, it forms a large polyester chain .…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Characterization of a Bioscaffold Using Hydroxyapatite and Unsaturated Polyester Resin

Kawcher Alam,

Sahadat Hossain,

Anisur Rahman Dayan

et al. 2024

ACS Omega

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Outstanding biodegradability and biocompatibility are attributes associated with particular polyester substances that make this group useful in specific biomedical fields. To assess the potential as a biomaterial, a novel composite consisting of hydroxyapatite (HAp) and unsaturated polyester resin (UPR) was developed in this work. Using a hand-lay-up technique, various percentages (50, 40, 30, 20, and 10%) of HAp were reinforced into the UPR matrix to fabricate composite materials out of glass sheets. Prior to processing of the composite samples, hydroxyapatite was chemically synthesized in a wet chemical manner. Using a universal testing machine (UTM), Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and thermogravimetric analysis (TGA), the fabricated samples were characterized. The crystallographic parameters of synthesized hydroxyapatite (HAp) were also estimated through a range of formulas. The optimal amount for hydroxyapatite was 40% according to the findings of the tensile strength (TS), tensile modulus (TM), percentage of elongation at break (EB), bending strength (BS), and bending modulus (BM). Improvements in TS, TM, BS, and BM for the ideal combination were 39.39, 9.21, 912.05, and 259.96%, in each case, over the controlled one. Thermogravimetric analysis (TGA) has been implemented to determine the degradation temperature of the fabricated composites up to 600 °C.

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Effect of Laser Power on Anisotropic Microstructure and Mechanical Behavior of Biomedical Ti-35Nb-15Zr (at%) Alloy Fabricated by Laser Powder Bed Fusion

et al. 2023

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Micro-hydroxyapatite reinforced Ti-based composite with tailored characteristics to minimize stress-shielding impact in bio-implant applications

Cited by 9 publications

References 40 publications

Improving Pure Titanium’s Biological and Mechanical Characteristics through ECAP and Micro-Arc Oxidation Processes

Improving Pure Titanium’s Biological and Mechanical Characteristics through ECAP and Micro-Arc Oxidation Processes

Fabrication and Characterization of a Bioscaffold Using Hydroxyapatite and Unsaturated Polyester Resin

Effect of Laser Power on Anisotropic Microstructure and Mechanical Behavior of Biomedical Ti-35Nb-15Zr (at%) Alloy Fabricated by Laser Powder Bed Fusion

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