Micro-Grippers with Femtosecond-Laser Machined In-Plane Agonist-Antagonist SMA Actuators Integrated on Wafer-Level by Galvanic Riveting

Garcés-Schröder, Mayra; Hecht, Lars; Vierheller, Anke; Leester-Schädel, Monika; Böl, Markus; Dietzel, Andreas

doi:10.3390/proceedings1040385

Cited by 14 publications

(10 citation statements)

References 3 publications

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“…Furthermore, the laser machining system includes a galvanometer scanner system (Scanlab RTC 5, Scanlab GmbH, Puchheim, Germany) embedded into a micromachining platform (Microstruct-C, 3DMicromac, Chemnitz, Germany). In the past, this laser system was already used to fabricate devices for nanoparticle precipitation [ 28 ], the analysis of pancreatic islets [ 29 ], point-of-care tests from nitrocellulose [ 30 ], and shape memory alloy (SMA) actuators made from NiTi material [ 31 ]. The fabrication process utilized in this work is shown in Figure 4 :…”

Section: Methodsmentioning

confidence: 99%

Particle-Based Microfluidic Quartz Crystal Microbalance (QCM) Biosensing Utilizing Mass Amplification and Magnetic Bead Convection

et al. 2018

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Microfluidic quartz crystal microbalances (QCM) can be used as powerful biosensors that not only allow quantifying a target analyte, but also provide kinetic information about the surface processes of binding and release. Nevertheless, their practical use as point-of-care devices is restricted by a limit of detection (LoD) of some ng/cm². It prohibits the measurement of small molecules in low concentrations within the initial sample. Here, two concepts based on superparamagnetic particles are presented that allow enhancing the LoD of a QCM. First, a particle-enhanced C-reactive protein (CRP) measurement on a QCM is shown. The signal response could be increased by a factor of up to five by utilizing the particles for mass amplification. Further, a scheme for sample pre-preparation utilizing convective up-concentration involving magnetic bead manipulation is investigated. These experiments are carried out with a glass device that is fabricated by utilizing a femtosecond laser. Operation regimes for the magnetic manipulation of particles within the microfluidic channel with integrated pole pieces that are activated by external permanent magnets are described. Finally, the potential combination of the concepts of mass amplification and up-concentration within an integrated lab-on-a chip device is discussed.

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Section: Methodsmentioning

confidence: 99%

Particle-Based Microfluidic Quartz Crystal Microbalance (QCM) Biosensing Utilizing Mass Amplification and Magnetic Bead Convection

et al. 2018

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“…Moreover, electromagnetic fields could disturb the measurement of the very weak electrical signals (in the picoampere range) during the electrophysiological measurements. Thermomechanical actuation, such as the shape memory alloy design [ 7 , 8 ], or the thermal expansion design [ 9 ], has the inevitable disadvantage of heat dissipation, which may impair the physiological function under study. These considerations limit the range of actuation principles that are compatible with the intended bioanalytical procedures to pneumatic, hydraulic, or mechanic actuations.…”

Section: Introductionmentioning

confidence: 99%

An Immersible Microgripper for Pancreatic Islet and Organoid Research

et al. 2022

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To improve the predictive value of in vitro experimentation, the use of 3D cell culture models, or organoids, is becoming increasingly popular. However, the current equipment of life science laboratories has been developed to deal with cell monolayers or cell suspensions. To handle 3D cell aggregates and organoids in a well-controlled manner, without causing structural damage or disturbing the function of interest, new instrumentation is needed. In particular, the precise and stable positioning in a cell bath with flow rates sufficient to characterize the kinetic responses to physiological or pharmacological stimuli can be a demanding task. Here, we present data that demonstrate that microgrippers are well suited to this task. The current version is able to work in aqueous solutions and was shown to position isolated pancreatic islets and 3D aggregates of insulin-secreting MIN6-cells. A stable hold required a gripping force of less than 30 mN and did not affect the cellular integrity. It was maintained even with high flow rates of the bath perfusion, and it was precise enough to permit the simultaneous microfluorimetric measurements and membrane potential measurements of the single cells within the islet through the use of patch-clamp electrodes.

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“…To introduce new robotic platforms to address the demands of the modern era, proper actuators and materials should be used to achieve the required specifications of the robotic platforms [13]. Shape memory alloys (SMA) [14], piezoelectric [15], Electrostatic MEMS [16], and hydraulic/pneumatic actuators [17] are among the widely used actuators to design better robots.…”

Section: Introductionmentioning

confidence: 99%

A Hydraulic Soft Microhand with an Application of Live Insect Manipulation

Kordmahale¹,

Qu²,

Muliana³

et al. 2021

Preprint

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We have developed micro scale hydraulic/pneumatic soft grippers and demonstrated the handling of an insect. These grippers are built on Polydimethylsiloxane (PDMS) with the soft material casting technique to form three finger-like columns, which are placed on a circular membrane. The fingers have a length of 1.5mm/2mm and a diameter of 300µm each; the distance between two fingers is 600µm of center-to-center distance. Membrane is built as a 150µm soft skin on the top of a cylindrical void. Applying a pressure difference between the interior of the void and the exterior can bend the membrane. Bending the membrane causes the motion of opening/closing of the gripper, and as a result, the three fingers can grip an object or release it. The PDMS was characterized and the experimental results were used later in Abaqus software to simulate the gripping motion. The produced force and range of deformation of the grippers were investigated by simulation and experiment. The results of the simulation agrees with the experiments. The maximum 543 µN force was measured for the microfluidic compatible microgrippers.Using this microhand gripper, the an ant was manipulated successfully without any damage. Results showed fabricated devices have great potential as a micro/bio manipulator.

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Micro-Grippers with Femtosecond-Laser Machined In-Plane Agonist-Antagonist SMA Actuators Integrated on Wafer-Level by Galvanic Riveting

Cited by 14 publications

References 3 publications

Particle-Based Microfluidic Quartz Crystal Microbalance (QCM) Biosensing Utilizing Mass Amplification and Magnetic Bead Convection

Particle-Based Microfluidic Quartz Crystal Microbalance (QCM) Biosensing Utilizing Mass Amplification and Magnetic Bead Convection

An Immersible Microgripper for Pancreatic Islet and Organoid Research

A Hydraulic Soft Microhand with an Application of Live Insect Manipulation

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