Micro-feeding and dosing of powders via a small-scale powder pump

Besenhard, Maximilian O.; Fathollahi, Sara; Siegmann, Eva; Slama, Eyke; Faulhammer, Eva; Khinast, Johannes G.

doi:10.1016/j.ijpharm.2016.12.029

Cited by 17 publications

(11 citation statements)

References 18 publications

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“…Moreover, the total amount of powder fed over time is constant and known. The presented work is a follow-up from the data presented by Besenhard et al ( 22 ). A more advanced design of the micro-feeder system with a number of improvements compared with the previous one was developed ( 22 ).…”

Section: Introductionmentioning

confidence: 67%

Performance Evaluation of a High-Precision Low-Dose Powder Feeder

et al. 2020

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Highly potent active pharmaceutical ingredients (APIs) and low-dose excipients, or excipients with very low density, are notoriously hard to feed with currently available commercial technology. The micro-feeder system presented in this work is capable of feeding low-dose rates of powders with different particle sizes and flow properties. Two different grades of lactose, di-calcium phosphate, croscarmellose sodium, silicon dioxide, a spray-dried intermediate, and an active ingredient were studied to vary material properties to test performance of the system. The current micro-feeder system is a volumetric feeder combined with a weighing balance at the outlet that measures feeder output rates. Feeding results are shown as a so-called “displacement-feed factor” curve for each material. Since the powder mass and volume are known in the micro-feeder system, in this work, we characterized an observed density variation during processing via a “displacement-feed factor” profile for each of the fed powders. This curve can be later used for calibrating the system to ensure an accurate, constant feed rate and in addition predicting feeding performance for that material at any feed rate. There is a relation between powder properties and feeding performance. Powders with finer particles and higher compressibility show densification during their feeding process. However, powders with larger particles and lower compressibility show both “densification” and “powder bed expansion,” which is the manifestation of dilation and elastic recovery of particles during the micro-feeding process. Through the application of the displacement-feed factor, it is possible to provide precise feeding accuracy of low-dose materials. Graphical abstract

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Section: Introductionmentioning

confidence: 67%

Performance Evaluation of a High-Precision Low-Dose Powder Feeder

et al. 2020

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“…Solutions for stable feeding of very small amounts have been previously introduced e.g. in the publications of Besenhard et al (Besenhard et al, 2017(Besenhard et al, , 2016. Particle engineering has also been postulated as a means to ensure a proper content uniformity with low drug load formulations (Sun et al, 2017).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Comparison between integrated continuous direct compression line and batch processing – The effect of raw material properties

Karttunen

Wikström

Tajarobi

et al. 2019

European Journal of Pharmaceutical Sciences

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“…The chamber has also a gas inlet that helps the solid to flow through the reactor inlet. The feeding principle is similar to that of the work of Besenhard et al 22 The solid feeding rate depends on the displacement speed of the syringe pump and it is independent of the gas flow introduced into the system. In this manner, the effect of the S/G ratio was studied independently of the gas velocity.…”

Section: Entrained Flow Reactor Descriptionmentioning

confidence: 97%