Micro-ecology restoration of colonic inflammation by in-Situ oral delivery of antibody-laden hydrogel microcapsules

Li, Bo; Li, Xin; Chu, Xiangxiang; Lou, Pengcheng; Yuan, Yin; Zhuge, Aoxiang; Zhu, Xueling; Shen, Yangfan; Pan, Jinghua; Zhang, Liyuan; Li, Lanjuan; Wang, Zhongwen

doi:10.1016/j.bioactmat.2021.12.022

Cited by 9 publications

(3 citation statements)

References 50 publications

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“…Polysaccharides participate in many biological activities, such as cytoskeleton formation, energy metabolism, blood glucose regulation and immunity modulation, are biocompatible and biodegradable, and can be easily extracted, processed and modified. Polysaccharides extracted from plants (for example, alginate 105,106 , cellulose 107 , starch 108 , carrageenan 109 , pectin 110 , guar gum 109 , mannan 111 , glucomannan 112 and inulin 113 ), animals (for example, chitosan 101,114 , hyaluronate 5 and chondroitin sulfate 115 ) and microbes (for example, pullulan 116 and β-glucan 117 ) are being explored for oral drug delivery. Polysaccharide nanoparticle formulations can orally deliver small molecules, oligonucleotides, peptides and proteins 94 .…”

Section: Biological Materialsmentioning

confidence: 99%

Bioinspired oral delivery devices

et al. 2023

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Oral administration is a widespread and convenient drug delivery approach. However, oral delivery can be affected by the complex digestive tract environment, including irregular tissue morphology, the presence of digestive enzymes, mucus and mucosal barriers, and spatiotemporal variance in physiological parameters. These obstacles can prevent the oral delivery of many therapeutics. To overcome these challenges, oral delivery devices can be designed with bioinspired compositions, structures or functions to make more drugs available for oral administration. Various bioinspired oral delivery devices have been developed by harnessing biological materials and living microorganisms, or by imitating biological structures and functions. In this Review, we discuss the design and modification of bioinspired oral delivery devices, examining engineering strategies to target specific tissues and applications. We highlight how key bottlenecks in oral delivery can be addressed through bioinspired designs, concluding with an outlook on the remaining challenges towards the clinical translation of bioinspired oral delivery devices. SectionsIntroduction Naturally derived oral delivery devices Bioinspired oral delivery Target tissues Outlook

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Section: Biological Materialsmentioning

confidence: 99%

Bioinspired oral delivery devices

et al. 2023

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“…[ 40 ] In‐situ delivery of therapeutic antibodies is one of the most important issues of in situ cancer immunotherapies that are mediated by injectable, edible, sprayable, or implantable hydrogels. [ 41 ] The swelling capacity of hydrogel can impact on antigen‐antibody interaction and chemical binding. Also, cell trafficking immune cell activation in recombinant proteins delivery or immunomodulatory drugs release is directly dependent on the swelling capacity index of the hydrogel as well as the porosity, power of hydrogen bond power, and biocompatibility focusing on osmotic properties.…”

Section: Physicochemical Properties Of Hydrogelsmentioning

confidence: 99%

Cancer Immunotherapy Using Bioengineered Micro/Nano Structured Hydrogels

Askari,

Shokrollahi Barough,

Rahmanian

et al. 2023

Adv Healthcare Materials

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Hydrogels, a class of materials with a three‐dimensional network structure, are widely used in various applications of therapeutic delivery, particularly cancer therapy. Micro and nanogels as a miniaturized structure of the bioengineered hydrogels could provide extensive benefits over the common hydrogels in encapsulation and controlled release of small molecular drugs, macromolecular therapeutics, and even cells. Cancer immunotherapy is rapidly developing, and micro/nanostructured hydrogels have gained wide attention regarding their engineered payload release properties that enhance systemic anticancer immunity. Additionally, they are a great candidate due to their local administration properties with the focus on local immune cells manipulation in favor of active and passive immunotherapies. Although applied locally, such micro/nanostructured can also activate systemic antitumor immune responses by releasing nanovaccines safely and effectively inhibiting tumor metastasis and recurrence. However, such hydrogels are mostly used as local administered carriers to stimulate the immune cells by releasing tumor lysate, drugs, or nanovaccines. In this review, we summarize the latest developments in cancer immunotherapy using micro/nanostructured hydrogels with a particular emphasis on their function depending on the administration route. Moreover, the potential for clinical translation of these hydrogel‐based cancer immunotherapies is also discussed.This article is protected by copyright. All rights reserved

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“…The formed polymeric network with suitable mechanical strength enables the sustained release of protein drugs as well as prevents their degradation by proteases [92a, 98] . Natural materials such as chitosan, alginate, and hyaluronic acid are commonly used to fabricate hydrogels due to their high biocompatibility [57a, 92b, 97a] . Stimuli‐responsive hydrogels are capable of undergoing conformational changes in response to physiological environmental signals, such as pH, temperature, redox, and ionic changes, leading to swelling of the hydrogel system and subsequent release of the drug [21, 92a] .…”

Section: Oral Protein Delivery Systemsmentioning

confidence: 99%

Recent Advances in Oral and Transdermal Protein Delivery Systems

et al. 2022

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Protein and peptide drugs are predominantly administered by injection to achieve high bioavailability, but this greatly compromises patient compliance. Oral and transdermal drug delivery with minimal invasiveness and high adherence represent attractive alternatives to injection administration. However, oral and transdermal administration of bioactive proteins must overcome biological barriers, namely the gastrointestinal and skin barriers, respectively. The rapid development of new materials and technologies promises to address these physiological obstacles. This review provides an overview of the latest advances in oral and transdermal protein delivery, including chemical strategies, synthetic nanoparticles, medical microdevices, and biomimetic systems for oral administration, as well as chemical enhancers, physical approaches, and microneedles in transdermal delivery. We also discuss challenges and future perspectives of the field with a focus on innovation and translation.

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Micro-ecology restoration of colonic inflammation by in-Situ oral delivery of antibody-laden hydrogel microcapsules

Cited by 9 publications

References 50 publications

Bioinspired oral delivery devices

Bioinspired oral delivery devices

Cancer Immunotherapy Using Bioengineered Micro/Nano Structured Hydrogels

Recent Advances in Oral and Transdermal Protein Delivery Systems

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