Micro-Capillary Coatings Based on Spiropyran Polymeric Brushes for Metal Ion Binding, Detection, and Release in Continuous Flow

Dunne, Aishling; Delaney, Colm; McKeon, Aoife; Nesterenko, Pavel N.; Paull, Brett; Benito‐Lopez, Fernando; Diamond, Dermot; Florea, Larisa

doi:10.3390/s18041083

Cited by 15 publications

(10 citation statements)

References 37 publications

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“…Another important component of complex hybrid photoactive molecules are photochromes [6][7][8], which also have a wide range of possible applications, such as optical molecular memory units, light-transforming membranes, sensors, etc. [9][10][11][12][13][14][15]. We have synthesized a hybrid compound whose molecule is built from photochromic spiropyran fragments and two fluorophores, 7-hydroxycoumarin and azomethin [16].…”

Section: Introductionmentioning

confidence: 99%

Excited State Proton Transfers in Hybrid Compound Based on Indoline Spiropyran of the Coumarin Type and Azomethinocoumarin in the Presence of Metal Ions

et al. 2021

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Spectral-luminescence properties of a hybrid compound containing a coumarin-type spiropyran and an azomethinocoumarin fragment in toluene-acetonitrile solution in the presence of Li+, Ca2+, Zn2+ and Mg2+ ions are reported. Two excited state proton transfers can occur in the hybrid compound—the transfer of a proton from the OH group of the 7-hydroxy coumarin tautomer to the N atom of the C=N bond of the azomethine fragment leading to green ESIPT fluorescence with a maximum at 540 nm and from the OH group of the 7-hydroxy coumarin tautomer to the carbonyl group of the pyrone chromophore, which leads to the formation of the 2-hydroxyl-tautomer T of coumarin with blue fluorescence with a maximum at 475 nm. Dependence of these excited state proton transfers on the metal nature and irradiation with an external UV source is discussed.

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Section: Introductionmentioning

confidence: 99%

Excited State Proton Transfers in Hybrid Compound Based on Indoline Spiropyran of the Coumarin Type and Azomethinocoumarin in the Presence of Metal Ions

et al. 2021

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“…Means of identifying this conformation change commonly include nuclear magnetic resonance (NMR) and optical methods such as UV/Vis, fluorescence, luminescence and optically detected magnetic resonance (ODMR) spectroscopic techniques. The significantly different physico-chemical properties between SP and MC allow for the utilization of SP in a wide variety of applications, such as switchable photo-induced polarity sensors [31], volume change actuators [32][33][34] and wettability modulators [35], as well as for photo-control of binding/release of ions [36][37][38][39], cell adhesion [40] and membrane permeability [41]. Moreover, these molecules can be used to tune surface morphology [33], mechanical properties [42,43] and surface stress [24,44].…”

mentioning

confidence: 99%

Silicon Microcantilever Sensors to Detect the Reversible Conformational Change of a Molecular Switch, Spiropyan

Grogan

Amarandei

Lawless

et al. 2020

Sensors

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The high sensitivity of silicon microcantilever sensors has expanded their use in areas ranging from gas sensing to bio-medical applications. Photochromic molecules also represent promising candidates for a large variety of sensing applications. In this work, the operating principles of these two sensing methods are combined in order to detect the reversible conformational change of a molecular switch, spiropyran. Thus, arrays of silicon microcantilever sensors were functionalized with spiropyran on the gold covered side and used as test microcantilevers. The microcantilever deflection response was observed, in five sequential cycles, as the transition from the spiropyran (SP) (CLOSED) to the merocyanine (MC) (OPEN) state and vice-versa when induced by UV and white light LED sources, respectively, proving the reversibility capabilities of this type of sensor. The microcantilever deflection direction was observed to be in one direction when changing to the MC state and in the opposite direction when changing back to the SP state. A tensile stress was induced in the microcantilever when the SP to MC transition took place, while a compressive stress was observed for the reverse transition. These different type of stresses are believed to be related to the spatial conformational changes induced in the photochromic molecule upon photo-isomerisation.Sensors 2020, 20, 854 2 of 12 areas ranging from gas, humidity and thermal sensing to novel applications in microbiology, genomics and cancer detection [9][10][11][12][13][14][15]. Innovative microcantilever coatings include polymer brushes-based on phenylboronic acid which have been used to detect glucose binding events [15] and graphene oxide (GO) thin films for high-sensitivity humidity sensing [16]. Other examples involve the use of microcantilever sensors for detection of various diseases through, for example, antibody-antigen interactions for the detection of disease-related C-reactive proteins or for the screening of heart-related diseases by using cardiomyocytes functionalized microcantilevers [17][18][19]. Different fabrication methods for microcantilevers as well as the range of available modification methods in the substrate and sensing layer allow for the realization of different types of cantilever-based sensors [20,21]. An improvement in microcantilevers sensor efficiency of the n-type over p-type silicon cantilevers was demonstrated, and this effect was explained by their greater piezoresistive coefficient [20]. Examples include micromachined silicon cantilever paddle sensors which can be used in high flow rate gas sensing [20,21], and resonant cantilevers for pressure sensing [22].Spiropyrans (SP) are one of the most popular families of photochromic molecules [23,24]. Upon irradiation with UV light, the orthogonal SP isomer converts to the planar merocyanine (MC) form due to the photo-cleavage of the C spiro -O bond. The MC isomer shows a strong absorption band in the visible region due to its conjugation. When the MC is exposed to visible light, the structu...

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“…• Soft stimuli-responsive polymer actuators for controlling flow direction and flow rate (Figure 1C) (Delaney et al, 2017;Saez et al, 2018). • Functionalised channels walls endowed with sensing capabilities for monitoring changes in pH, metal ion concentrations, solvent polarity, and biochemistry (Figure 1D) (Florea et al, 2012(Florea et al, , 2013a(Florea et al, , 2013bLuka et al, 2015;Shakeri et al, 2022;Dunne et al, 2018). • Surface tension/interfacial tension modulation for flow (regime) control and fluid mixing (Diguet et al, 2011;Venancio-Marques et al, 2013).…”

Section: Strategies For Extending Biochemical Sensor Lifetimementioning

confidence: 99%

Sensors and “The internet of biochemical things”

Florea

Diamond²

2022

Front. Sens.

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In this perspective article, we consider the pathway biochemical sensing will take as the huge businesses underpinning Big Data and the Internet of Things seek new layers of highly valuable information to integrate into our increasingly digitised world. Up to now, the complexity of biochemical sensing has limited its inclusion in a manner similar to more reliable and lower cost technologies based on physical transducers. At its core, this complexity arises from the fundamental need for biochemical sensors to interact intimately at the molecular level with one or more specific components (analytes) in samples that are often highly complex and hostile to the sensors. This limits the functional lifetime of biochemical sensors to at best days or weeks or most commonly single use, making long-term embedded use-models developed for Internet of Things applications beyond reach. Nevertheless, even single use sensors can lead to “big data”, if used in large enough scale (e.g., COVID-19 diagnostics), and progress in continuous is beginning to make headway towards longer-term use models in health and environmental monitoring. New concepts exploiting advanced materials and biomimetic concepts offer opportunities to further extend the lifetime of biochemical sensing devices.

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Micro-Capillary Coatings Based on Spiropyran Polymeric Brushes for Metal Ion Binding, Detection, and Release in Continuous Flow

Cited by 15 publications

References 37 publications

Excited State Proton Transfers in Hybrid Compound Based on Indoline Spiropyran of the Coumarin Type and Azomethinocoumarin in the Presence of Metal Ions

Excited State Proton Transfers in Hybrid Compound Based on Indoline Spiropyran of the Coumarin Type and Azomethinocoumarin in the Presence of Metal Ions

Silicon Microcantilever Sensors to Detect the Reversible Conformational Change of a Molecular Switch, Spiropyan

Sensors and “The internet of biochemical things”

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