“…For example, microlens arrays require relief microstructures with smooth convex surface profiles, and in vitro modeling of blood vessels requires circular microchannels. − In recent years, spherical hollow features have attracted considerable attention from scientists and engineers due to their wide applications in biomedical and optical fields. Extensive efforts have therefore been devoted to the construction of spherical microcavities, including thermally reflowed microball molding, , magnet-assisted microbead molding, , gas expansion molding, − and droplet molding. − Due to the geometrical contraction of the spherical microcavity’s opening, the replication of spherical microcavities from microballs or microbeads inevitably suffers from the difficulty of demolding or even obtaining fractured spherical microcavities. The gas expansion molding method offers an elegant solution for this problem, which exploits the expansion of air trapped inside the patterned pits to fabricate the spherical microcavity arrays without requiring demolding.…”