Micro-assembly using optically controlled bubble microrobots in saline solution

Hu, Wenqi; Ishii, K.; Ohta, Aaron T.

doi:10.1109/icra.2012.6225284

Cited by 20 publications

(13 citation statements)

References 28 publications

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“…Bubble microrobots can be utilized to perform microassembly by pushing multiple objects in a pattern. The authors have demonstrated independent control of three bubble microrobots to realize parallel manipulation [39]. However, these bubble microrobots also suffer from limited manipulation force capabilities, thus restricting their applications.…”

Section: Multi-microrobot Control Using Optical Energymentioning

confidence: 97%

Controlling multiple microrobots: recent progress and future challenges

2015

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Robots the size of several microns have numerous application in medicine, biology, and manufacturing. However, simultaneous control of multiple robots at this scale is difficult since the robot itself is too small to carry power, sensors, communication, and control on-board. In this paper, we have summarized different approaches, ranging from specialized robot design and fabrication to specialized ways of actuating robots, with the aim of independent control of a team/swarm of microrobots. We have also discussed the challenges for each approach. In the light of the challenges, we have proposed some directions where the future researchers can focus in order to solve the problem of independent control of a team of microrobots.

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Section: Multi-microrobot Control Using Optical Energymentioning

confidence: 97%

Controlling multiple microrobots: recent progress and future challenges

2015

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“…The optically absorbent substrate is a 1.1-mm-thick glass slide coated with a 200-nmthick layer of indium tin oxide (ITO), and a 1-μm-thick layer of amorphous silicon (α-silicon). The ITO and α-silicon layers of the absorbent substrate absorb 70% of the incident laser light [20], heating up the substrate and creating air microbubbles in the water solution.…”

Section: A Setup Of the Poration Systemmentioning

confidence: 99%

Molecular delivery and transfection by laser-induced oscillating microbubbles

Fan

Ohta

2014

The 9th IEEE International Conference on Nano/Micro Engineered and Molecular Systems (NEMS)

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Exogenous molecules were successfully delivered into localized single mammalian adherent cells with oscillating microbubbles induced by microsecond laser pulses. The shear stress due to the oscillation of the microbubble causes the poration of a nearby cell. Specific single cells can be porated by adjusting the laser position to create the microbubbles beneath the target cell. The poration of localized single cells was demonstrated with the delivery of 500-kDa FITC-Dextran dye and 16-kb plasmids.

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“…The optically absorbent substrate consisted of a 1.1-mm-thick glass slide coated with a 200-nm-thick layer of indium tin oxide (ITO), topped by a 1-μm-thick layer of amorphous silicon (α-silicon). The majority of the incident light (70%) was absorbed in the ITO and α-silicon layers of the absorbent substrate [20] and converted into heat, creating microbubbles at the surface of the substrate. The laser pulse was controlled with a function generator (Agilent 33220A) to change pulse width and frequency, allowing control over the bubble size and oscillation speed.…”

Section: Light-induced Microbubble Poration Of Localized Cellsmentioning

confidence: 99%

Light-induced microbubble poration of localized cells

Fan

Ohta

2013

2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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Molecular delivery into localized NIH/3T3 cells was achieved with microbubbles produced by laser pulses focused on an optically absorbent substrate. The laser-induced bubble expansion and contraction resulted in cell poration. The microbubbles are localized at the laser focal point, so molecular delivery can be directed at specific localized cells. This was demonstrated with the delivery of 3-kDa FITC-Dextran. Single-cell molecular delivery was achieved, even in the presence of nearby cells. The efficiency of the cell poration was up to 95%, with a corresponding cell viability of 98%.

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Micro-assembly using optically controlled bubble microrobots in saline solution

Cited by 20 publications

References 28 publications

Controlling multiple microrobots: recent progress and future challenges

Controlling multiple microrobots: recent progress and future challenges

Molecular delivery and transfection by laser-induced oscillating microbubbles

Light-induced microbubble poration of localized cells

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