Micro- and macrorheology of mucus

Lai, Samuel K.; Wang, Xiaocong; Wirtz, Denis; Hanes, Justin

doi:10.1016/j.addr.2008.09.012

Cited by 1,010 publications

(1,102 citation statements)

References 180 publications

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“…An integrated structure of biopolymers describes the mucus at the chemical level [24]. The physical behavior of this structure is a complex non-Newtonian, thixotropic gel.…”

Section: Mucus Nanoparticle Interaction Studies Via Rheological Measumentioning

confidence: 99%

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Methods to determine the interactions of micro- and nanoparticles with mucus

Grießinger¹,

Dünnhaupt²,

Cattoz

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

100

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“…An integrated structure of biopolymers describes the mucus at the chemical level [24]. The physical behavior of this structure is a complex non-Newtonian, thixotropic gel.…”

Section: Mucus Nanoparticle Interaction Studies Via Rheological Measumentioning

confidence: 99%

“…According to shear stress mucus acts as a viscous liquid or an elastic solid. The rheological properties of mucus differ as a function of shear stress, time rate of shearing and length scale [24].…”

Section: Mucus Nanoparticle Interaction Studies Via Rheological Measumentioning

confidence: 99%

Methods to determine the interactions of micro- and nanoparticles with mucus

Grießinger¹,

Dünnhaupt²,

Cattoz

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

100

View full text Add to dashboard Cite

“…To overcome this biological barrier caused by some novel inhalation pharmaceuticals, functionalized and nontoxic nanocarriers can be used. Inspired from viruses, nanosized particles with neutrally charged coatings such as polyethylene glycol (PEG) can efficiently penetrate the mucus layer in contrast to charged particles (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

A Model for the Transient Subdiffusive Behavior of Particles in Mucus

Ernst¹,

John

Guenther³

et al. 2017

Biophysical Journal

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In this study we have applied a model to explain the reported subdiffusion of particles in mucus, based on the measured mean squared displacements (MSD). The model considers Brownian diffusion of particles in a confined geometry, made from permeable membranes. The applied model predicts a normal diffusive behavior at very short and long time lags, as observed in several experiments. In between these timescales, we find that the ''subdiffusive'' regime is only a transient effect, MSDft a ; a < 1. The only parameters in the model are the diffusion-coefficients at the limits of very short and long times, and the distance between the permeable membranes L. Our numerical results are in agreement with published experimental data for realistic assumptions of these parameters. Finally, we show that only particles with a diameter less than 40 nm are able to pass through a mucus layer by passive Brownian motion.

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“…Viscosity values of human respiratory mucus of 12 to 15 Pa·s with a relaxation time of about 40 s and an elastic modulus of 1 to 2 Pa is supposed to represent an optimal rheological profile for mucociliary clearance [98]. Mucus possess pseudoplasticity, elastothixotropy, spinability (capacity to be drawn out into long threads [Spinnbarkeit]) and adhesiveness [99].…”

Section: Mucus Propertiesmentioning

confidence: 99%

Biofluid Flow and Heat Transfer

Thiriet¹,

Sheu²,

Garon³

2016

Handbook of Fluid Dynamics, Second Edition

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2nd EditionInternational audienceMajor moving biological fluids, or biofluids, are blood and air that cooperate to bring oxygento the body’s cells and eliminate carbon dioxide produced by these cells. Blood is conveyed ina closed network composed of 2 circuits in series — the systemic and pulmonary circulation—, each constituted by arteries, capillaries, and veins, under the synchronized action of theleft and right cardiac pumps, respectively. Air is successively inhaled from and exhaled to theatmosphere through the airway openings (nose and/or mouth). In the head, blood generatesthe cerebrospinal fluid in choroid plexi of all compartments of the ventricular system andreceives it in arachnoid villi. Other biofluids are either secreted, such as bile from the liverand breast milk that both transport released substances with specific tasks, or excreted,such as urine from kidneys or sweat from skin glands that both convey useless materials andwaste produced by the cell metabolism. In addition to the convective transport, peristalsis,which results from the radial contraction and relaxation of mural smooth muscles, propelsthe content of the lumen of the muscular bioconduit (e.g., digestive tract) in an anterogradedirection.Blood circulation and air flow in the respiratory tract are widely explored because oftheir vital functions. Note that inhaled air is transported through the respiratory tract bytwo processes: convection down to bronchioles and diffusion down to pulmonary alveoli.1Furthermore, investigations of these physiological flows in deformable bioconduits give riseto models such as the Starling resistance that themselves become object of new study fieldsin physics and mechanics (e.g., collapsible tubes) as well as of new developments in math-ematical modeling and scientific computing. Whereas fluid–structure interaction problemsin aeronautics and civil engineering deal with materials of distinct properties, blood streamand vessel wall correspond to two domains of nearly equal physical properties, as both bloodand vessels have densities close to that of water. New processing strategies must then beconceived

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Micro- and macrorheology of mucus

Cited by 1,010 publications

References 180 publications

Methods to determine the interactions of micro- and nanoparticles with mucus

Methods to determine the interactions of micro- and nanoparticles with mucus

A Model for the Transient Subdiffusive Behavior of Particles in Mucus

Biofluid Flow and Heat Transfer

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