Micro- and Macrocystic Lymphatic Malformation

McCormack, Lindsay; Jones, Krystal M.; Huang, Jennifer T.

doi:10.1016/j.jpeds.2019.12.004

Cited by 10 publications

(7 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The ML classifications were based on a previous classification modified by Kim et al in 2016 ( 1 ). The pathological types referred to the types described in previous studies, including macrocystic-type (≥1 cm), microcystic-type (<1 cm), and mixed cystic-type ( 12 , 13 ). The size of the ML was defined as the length of the cyst.…”

Section: Methodsmentioning

confidence: 99%

Preoperative complications in children with mesenteric lymphatic malformations: Incidence, risk factors and outcomes

et al. 2022

View full text Add to dashboard Cite

BackgroundPreoperative complications of mesenteric lymphatic malformations (ML) in children are various and complex. We aim to analyze the incidences and risk factors of three major preoperative complications (hemorrhage of the cyst, infection of the cyst and intestinal volvulus) in ML patients, and explore their influence on the outcomes.MethodsThis retrospective cohort study enrolled ML patients undergoing surgery at Beijing Children's Hospital between June 2016 and June 2022 and classified them according to different preoperative complications, preoperative hemorrhage or infection, and preoperative intestinal volvulus. The groups were examined and compared according to sex, age at admission, presenting symptoms, laboratory examinations, imaging examinations, preoperative treatments, cyst characteristics, surgical details, perioperative clinical data, and follow-up. Logistic regression analysis was performed to identify the independent risk factors for preoperative hemorrhage or infection, and preoperative intestinal volvulus.ResultsOf the 104 enrolled ML patients, 27 (26.0%) had preoperative hemorrhage or infection, and 22 (21.2%) had preoperative intestinal volvulus. Univariate analysis showed that patients with preoperative hemorrhage or infection had a higher rate of ML in the mesocolon (44.4 vs. 23.4%, p < 0.038) and larger cysts (10 vs. 8 cm, p = 0.042) than patients without preoperative hemorrhage or infection. Multivariable logistic regression analysis found that the location (OR, 3.1; 95% CI, 1.1–8.6; p = 0.026) and size of the cyst (≥7.5 cm) (OR, 6.2; 95% CI, 1.6–23.4; p = 0.007) were independent risk factors for preoperative hemorrhage or infection. Preoperative intestinal volvulus was only found in ML at the intestinal mesentery. Further analysis showed that ML in the jejunal mesentery was an independent risk factor for preoperative intestinal volvulus (OR, 3.3; 95% CI, 1.1–10.0; p = 0.027). Patients with preoperative hemorrhage or infection spent more on hospitalization costs than patients without preoperative hemorrhage or infection (3,000 vs. 2,674 dollars, p = 0.038).ConclusionsML patients should be treated as soon as possible after diagnosis. The location and size of the cyst were independent risk factors for preoperative hemorrhage or infection. ML in the jejunal mesentery was an independent risk factor for preoperative intestinal volvulus.

show abstract

Section: Methodsmentioning

confidence: 99%

Preoperative complications in children with mesenteric lymphatic malformations: Incidence, risk factors and outcomes

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Considering that the previously reported classifications of ML could not be applied to OL, a simple classification of OL reported was used in this study, including Group 1 (patients with clinical features due to the size of the cyst), Group 2 (patients with clinical features due to the preoperative complications of the cyst), and Group 3 (patients without clinical features but whose cysts were incidentally detected) [ 4 , 6 , 17 ]. According to the number and size of the cysts contained, the pathological types included macrocystic-type (single or multilocular, ≥ 1 cm), microcystic-type (single or multilocular, < 1 cm) and mixed cystic-type (multilocular) [ 18 , 19 ]. Both ML and OL are almost cystic lymphatic malformations, making it impossible to measure their specific length, width and height; thus, in our study, the size of the cysts refers to the length of the entire cyst that was obtained from surgical records for patients undergoing open surgery and from preoperative imaging findings for patients undergoing laparoscopic surgery.…”

Section: Methodsmentioning

confidence: 99%

Mesenteric and omental lymphatic malformations in children: seven-year surgical experience from two centers in China

Yan,

Fu,

Liu

et al. 2024

BMC Pediatr

View full text Add to dashboard Cite

Purpose To compare the clinical characteristics, surgical management and prognosis of mesenteric lymphatic malformations (ML) and omental lymphatic malformations (OL) in children. Methods This retrospective study included 148 ML patients and 53 OL patients who underwent surgical treatment at two centers between January 2016 and December 2022. Details about the patients’ clinical characteristics, cyst characteristics, preoperative complications, surgical methods, and prognosis were retrieved and compared. Results No significant differences in sex ratio, prenatal diagnosis, or age of diagnosis were noted between ML and OL patients. Vomiting was more common in ML patients than in OL patients (46.6% vs. 22.6%, P = 0.002), but OL patients were more likely to be misdiagnosed (35.8% vs. 18.9%, P = 0.012). The size of the cysts in OL patients was significantly larger than that in ML patients (14.0 [4.0–30.0] vs. 10.0 [2.0–50.0] cm, P<0.001), and cysts with turbid fluid were more common in OL patients (38.0% vs. 20.6%, P<0.001). More OL patients than ML patients had preoperative hemorrhage or infection of cysts (41.5% vs. 31.8%, P<0.016). Cyst excision was performed in 137 (92.6%) ML patients and 51 (96.2%) OL patients, and the incidence of postoperative complications was lower (12.6% vs. 4.2%, P = 0.165) among OL patients. The main postoperative complications included adhesive ileus and recurrence of cysts. Additionally, more OL patients than ML patients were treated with laparoscopic surgery (69.8% vs. 39.2%, P<0.001). Conclusions There were differences in clinical characteristics, cyst characteristics and preoperative complications between ML and OL patients. Cyst excision was the most common surgical method that was used to treat both ML and OL patients, and laparoscopic surgery could be a feasible surgical approach for treating OL patients with a good prognosis. Trial registration Retrospectively registered.

show abstract

“…Considering that the previously reported classi cations of ML could not be applied to OL, the simple classi cation of OL reported was used in this study, including Group 1 (patients with clinical features due to the size of the cyst), Group 2 (patients with clinical features due to the preoperative complications of the cyst), and Group 3 (patients without clinical features but incidentally detected) [4,6,17]. According to the number and size of cysts contained, the pathological types included macrocystic-type (single or multilocular, ≥ 1 cm), microcystic-type (single or multilocular, < 1 cm) and mixed cystic-type (multilocular) [18,19]. The size of the cysts referred to the length of the entire cyst obtained from surgical records for patients undergoing open surgery and from preoperative imaging ndings for patients undergoing laparoscopic surgery.…”

Section: Methodsmentioning

confidence: 99%

Mesenteric and omental lymphatic malformations in children: seven-year surgical experience from two centers in China

Yan

Fu²,

Liu

et al. 2023

Preprint

View full text Add to dashboard Cite

Purpose To compare the clinical characteristics, surgical management and prognosis of mesenteric lymphatic malformations (ML) and omental lymphatic malformations (OL) in children. Methods This retrospective study included 148 ML patients and 53 OL patients who underwent surgical treatment at two centers between January 2016 and December 2022. Details of the patients’ clinical characteristics, cyst characteristics, preoperative complications, surgical methods, and prognosis were retrieved and compared. Results No significant differences between ML and OL patients were noted in sex ratio, prenatal diagnosis, and age of diagnosis. The presence of vomiting was more common in ML patients than in OL patients (46.6% vs. 22.6%, P = 0.002), but OL patients were more likely to be misdiagnosed (35.8% vs. 18.8%, P = 0.012). The size of cysts in OL patients was significantly larger than that in ML patients (14.0 [8.0, 17.3] vs. 10.0 [6.0, 13.0] cm, P＜0.001), and cysts with turbid fluid were more common in OL patients (38.0% vs. 20.6%, P＜0.001). Cyst excision was performed in 137 (92.6%) ML patients and 51 (96.2%) OL patients, and the incidence of postoperative complications was lower (12.6% vs. 4.2%, P = 0.165) among the latter. The main postoperative complications included adhesive ileus and recurrence of cysts. Additionally, laparoscopic surgery was more commonly undergone among OL patients (69.8% vs. 39.2%, P＜0.001). Conclusions Compared with ML patients, OL patients are more prone to misdiagnosis and infection, but the prognosis of surgical treatment is better. Laparoscopic cyst excision may be the preferred treatment for OL patients.

show abstract

Micro- and Macrocystic Lymphatic Malformation

Cited by 10 publications

References 2 publications

Preoperative complications in children with mesenteric lymphatic malformations: Incidence, risk factors and outcomes

Preoperative complications in children with mesenteric lymphatic malformations: Incidence, risk factors and outcomes

Mesenteric and omental lymphatic malformations in children: seven-year surgical experience from two centers in China

Mesenteric and omental lymphatic malformations in children: seven-year surgical experience from two centers in China

Contact Info

Product

Resources

About