MicRNA-320 facilitates the brain parenchyma injury via regulating IGF-1 during cerebral I/R injury in mice

Liu, Liang; Wang, Jun; Yuan, Yanrong; Zhang, Yan; Liu, Huili; Wu, Chunli; Yan, Yongmin

doi:10.1016/j.biopha.2018.03.036

Cited by 31 publications

(15 citation statements)

References 18 publications

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“…In case of neurodegeneration, oxidative stress dependent neurotoxicity and apoptosis was linked with following microRNAs: miR-98 , miR-132 , miR-153 , miR-200a , miR-186 , miR-221 , miR-196a , miR-22 , miR-107 , miR-223 , miR-320 , miR-125b , miR-181 , miR-365 , miR-193 , miR-49 , miR-378 , miR-25 , miR-30d-5p , miR-26b , miR-592-5p , miR-153 , miR-155 , miR-212 , miR-183/96/182 cluster, miR-146a [94,151,153,154,155,156,157,158,159,160,161,162,163,164,165,166,167,168,169,170,171,172,173,174,175,176,177,178,179,180,181,182,183,184,185,186]. MicroRNAs that are linked to the therapy resistance and sensitivity are the ones engaged in cancer cell survival.…”

Section: More About Microrna In Neuropathologymentioning

confidence: 99%

MicroRNA in Brain pathology: Neurodegeneration the Other Side of the Brain Cancer

Godlewski

Lenart

Salińska

2019

ncRNA

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The mammalian brain is made up of billions of neurons and supporting cells (glial cells), intricately connected. Molecular perturbations often lead to neurodegeneration by progressive loss of structure and malfunction of neurons, including their death. On the other side, a combination of genetic and cellular factors in glial cells, and less frequently in neurons, drive oncogenic transformation. In both situations, microenvironmental niches influence the progression of diseases and therapeutic responses. Dynamic changes that occur in cellular transcriptomes during the progression of developmental lineages and pathogenesis are controlled through a variety of regulatory networks. These include epigenetic modifications, signaling pathways, and transcriptional and post-transcriptional mechanisms. One prominent component of the latter is small non-coding RNAs, including microRNAs, that control the vast majority of these networks including genes regulating neural stemness, differentiation, apoptosis, projection fates, migration and many others. These cellular processes are also profoundly dependent on the microenvironment, stemness niche, hypoxic microenvironment, and interactions with associated cells including endothelial and immune cells. Significantly, the brain of all other mammalian organs expresses the highest number of microRNAs, with an additional gain in expression in the early stage of neurodegeneration and loss in expression in oncogenesis. However, a mechanistic explanation of the concept of an apparent inverse correlation between the odds of cancer and neurodegenerative diseases is only weakly developed. In this review, we thus will discuss widespread de-regulation of microRNAome observed in these two major groups of brain pathologies. The deciphering of these intricacies is of importance, as therapeutic restoration of pre-pathological microRNA landscape in neurodegeneration must not lead to oncogenesis and vice versa. We thus focus on microRNAs engaged in cellular processes that are inversely regulated in these diseases. We also aim to define the difference in microRNA networks between pro-survival and pro-apoptotic signaling in the brain.

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Section: More About Microrna In Neuropathologymentioning

confidence: 99%

MicroRNA in Brain pathology: Neurodegeneration the Other Side of the Brain Cancer

Godlewski

Lenart

Salińska

2019

ncRNA

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“…In a traumatic brain injury (TBI) rat model, IGF-1 is shown to increase in the ipsilateral side of the brain injury (Santi et al, 2018). In addition, exogenous IGF-1 has been found to protect the cerebral parenchyma in stroke models and to result in improved neurological outcomes (Liang et al, 2018). Generally, IGF-1 combines with IGF-1 receptor (IGF-1R) to exert functions.…”

Section: Introductionmentioning

confidence: 99%

Astrocytic Insulin-Like Growth Factor-1 Protects Neurons Against Excitotoxicity

Chen

Tong

et al. 2019

Front. Cell. Neurosci.

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Background Exogenous insulin like growth factor-1 (IGF-1) is known to be neuroprotective in animal models with brain insults, while it can also cause hyperexcitability in rodents. In this regard, the role of endogenous IGF-1 in brain responses to brain insults like excitotoxicity, a common pathology in brain injuries, remains to be elucidated. Here, we investigated the potential role of cell-specific endogenous IGF-1 in the kainic acid (KA) -induced degeneration of the neurons. Methods Kainic acid was given to primary cultured cortical neurons and co-cultured astrocytes were added as a supportive system. We evaluated the cell proliferation rate, IGF-1 level in different groups and applied the PCR-Chip assay to explore the downstream of IGF-1. In addition, we applied the viral transfer of astrocytic IGF-1 to rodents treated with KA and assessed the associated molecular marker and behavioral outcomes in these rodents. Results We found KA induced increased cell death and hyperphosphorylated tau in neurons; co-cultured astrocytes could prevent these pathologies, and this rescuing effect was abrogated with blockade of the astrocytic IGF-1 with AG1024 (IGF-1R inhibitor). PCR-Chip assay identified that astrocytic IGF-1 could decrease the p-GSK-3 at Tyr 216 in neurons treated with KA and this effect was abrogated with AG1024 as well. In addition, in vivo study showed that gene transfer of astrocytic IGF-1 decreased p-tau and cognitive dysfunction in KA mice. Conclusion Our results show astrocytic IGF-1 exhibits neuroprotective properties in neurodegenerative processes in the CNS.

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“…PTEN suppresses axon and neurite regeneration by inhibiting the activation of the PI3K-Akt pathway [ 74 ]. Moreover, miR-320-3p can also target IGF-1 [ 75 ]. IGF-1 modulates brain plasticity by affecting neurite growth, synapse formation, neuronal excitability, and neurotransmitter release [ 76 ].…”

Section: Discussionmentioning

confidence: 99%

Deep Sequencing of the Rat MCAO Cortexes Reveals Crucial circRNAs Involved in Early Stroke Events and Their Regulatory Networks

Wang

Yang

et al. 2021

Neural Plasticity

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Circular RNAs (circRNAs) are highly enriched in the central nervous system and significantly involved in a range of brain-related physiological and pathological processes. Ischemic stroke is a complex disorder caused by multiple factors; however, whether brain-derived circRNAs participate in the complex regulatory networks involved in stroke pathogenesis remains unknown. Here, we successfully constructed a cerebral ischemia-injury model of middle cerebral artery occlusion (MCAO) in male Sprague-Dawley rats. Preliminary qualitative and quantitative analyses of poststroke cortical circRNAs were performed through deep sequencing, and RT-PCR and qRT-PCR were used for validation. Of the 24,858 circRNAs expressed in the rat cerebral cortex, 294 circRNAs were differentially expressed in the ipsilateral cerebral cortex between the MCAO and sham rat groups. Cluster, GO, and KEGG analyses showed enrichments of these circRNAs and their host genes in numerous biological processes and pathways closely related to stroke. We selected 106 of the 294 circRNAs and constructed a circRNA-miRNA-mRNA interaction network comprising 577 sponge miRNAs and 696 target mRNAs. In total, 15 key potential circRNAs were predicted to be involved in the posttranscriptional regulation of a series of downstream target genes, which are widely implicated in poststroke processes, such as oxidative stress, apoptosis, inflammatory response, and nerve regeneration, through the competing endogenous RNA mechanism. Thus, circRNAs appear to be involved in multilevel actions that regulate the vast network of multiple mechanisms and events that occur after a stroke. These results provide novel insights into the complex pathophysiological mechanisms of stroke.

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MicRNA-320 facilitates the brain parenchyma injury via regulating IGF-1 during cerebral I/R injury in mice

Cited by 31 publications

References 18 publications

MicroRNA in Brain pathology: Neurodegeneration the Other Side of the Brain Cancer

MicroRNA in Brain pathology: Neurodegeneration the Other Side of the Brain Cancer

Astrocytic Insulin-Like Growth Factor-1 Protects Neurons Against Excitotoxicity

Deep Sequencing of the Rat MCAO Cortexes Reveals Crucial circRNAs Involved in Early Stroke Events and Their Regulatory Networks

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