Micosis fungoide. Experiencia en un hospital pediátrico

Cervini, Andrea Bettina; Torres-Huamani, A.N.; Sanchez-La-Rosa, C.; Galluzzo, Laura; Solernou, Verónica; Digiorge, Jorge; Rubio, P.

doi:10.1016/j.ad.2017.01.008

Cited by 9 publications

(7 citation statements)

References 18 publications

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“…It is usually diagnosed in early stages with no lymph node involvement, and although recurrence is common, progression is unusual. Additionally, HMF is commonly overrepresented in pediatric case series [ 74 , 75 , 76 ], where patients maintain adequate immunity.…”

Section: Clinical/demographic Patient Characteristics As a Results mentioning

confidence: 99%

“…Among all the mixed MF cases reported, three were staged as ≥II, two patients in stage IIA (early disease), and one patient in stage IVA. The latter was treated with chemotherapy and remained disease-free after 7 years of follow-up [ 76 ] ( Table 2 ). In addition, one patient was reported to have large cell transformation ( Table 2 ), which usually portends a worse prognosis; however, the patient responded well to phototherapy and topical steroids [ 81 ].…”

Section: Clinical/demographic Patient Characteristics As a Results mentioning

confidence: 99%

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Hypopigmented Mycosis Fungoides: Loss of Pigmentation Reflects Antitumor Immune Response in Young Patients

Villarreal

Gantchev

Lagacé

et al. 2020

Cancers

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Hypopigmented mycosis fungoides (HMF) is a form of cutaneous T-cell lymphoma (CTCL), a heterogeneous group of extranodal non-Hodgkin’s lymphomas. HMF has a unique set of defining features that include light colored to achromic lesions, a predilection for darker skin phototypes, an early onset of disease, and predominance of CD8+ T-cells, among others. In the current review, we detail the known pathways of molecular pathogenesis for this lymphoma and posit that an active Th1/cytotoxic antitumor immune response in part explains why this variant is primarily seen in children/adolescents and young adults, who do not exhibit signs of immunosenescence. As a result of this potent cytotoxic response, HMF patients experience mostly favorable overall prognosis, while hypopigmentation may in fact represent a useful surrogate marker of cytotoxic immunity targeting the malignant cells. Understanding the molecular processes behind the specific features that define HMF may lead to improved diagnostic accuracy, personalized prognosis by risk stratification, and improved management of HMF. Moreover, improving our knowledge of HMF may aid our further understanding of other cutaneous lymphomas.

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Section: Clinical/demographic Patient Characteristics As a Results mentioning

confidence: 99%

Section: Clinical/demographic Patient Characteristics As a Results mentioning

confidence: 99%

Hypopigmented Mycosis Fungoides: Loss of Pigmentation Reflects Antitumor Immune Response in Young Patients

Villarreal

Gantchev

Lagacé

et al. 2020

Cancers

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“…1 -3 The reported mean age at diagnosis in our study was younger than other pediatric studies. 19 -26 A lower threshold for biopsy in patients at our institution to exclude pediatric MF might explain this difference in age. Moreover, the pathological diagnosis of MF can easily be missed, and several biopsies can be necessary to establish the diagnosis.…”

Section: Discussionmentioning

confidence: 96%

“…19 -21,23 -29 Pediatric MF may show the classic presentation of erythematous patches and plaques with lymphocyte epidermotropism, yet various atypical clinical variants have been reported, including hypopigmented, psoriasiform, granulomatous slack skin, follicular, poikilodermic and purpuric. 19,21 -23,29,30 The hypopigmented variant seems to be overrepresented in childhood MF, 19,22,24,25,28 -32 and this clinical subtype is more often associated with a cytotoxic phenotype with expression of CD8 and TIA-1 reflecting the adequate antitumor immune response, which explains the better prognosis of that variant. 31,33 The association of MF with PLC has already been noted in other studies 33,34 and has been reported in a ratio as high as four out of five patients.…”

Section: Discussionmentioning

confidence: 99%

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Pediatric Cutaneous Hematologic Disorders: Cutaneous Lymphoma and Leukemia Cutis—Experience of a Tertiary-Care Pediatric Institution and Review of the Literature

et al. 2022

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Background Cutaneous hematologic malignancies are rare in children, and the literature about them is still sparse. Objective The purpose of our study was to report our experience with pediatric cases of cutaneous hematologic disorders and describe their clinical and histological features. Methods Data were retrospectively collected from the histopathologic database of the CHU Sainte-Justine, University of Montreal, Montreal, Canada. All patients up to 18 years of age with a diagnosis of a primary cutaneous lymphoma (including lymphomatoid papulosis), secondary cutaneous lymphoma or cutaneous manifestations of leukemia, followed from 1980 to 2019 at our center were reviewed. Results Thirty-six patients were included. Age at presentation ranged from birth to 18 years of age (mean 7.83 ± 5.16; median 7.0). Ten different hematologic disorders were identified according to the WHO-EORTC classifications: lymphomatoid papulosis (10 cases), mycosis fungoides (6 cases), anaplastic large cell lymphoma (4 cases), pre-B acute lymphoid leukemia (5 cases), primary cutaneous marginal zone B-cell lymphoma (4 cases), primary cutaneous CD4+medium T-cell lymphoproliferative disorder (1 case), extranodal NK/T-cell lymphoma (1 case), hydroa vacciniforme-like lymphoproliferative disorder (1 case), B-cell lymphoblastic lymphoma (1 case) and acute myeloid leukemia (3 cases). Conclusion The most common subtype of cutaneous hematologic disease in our single institution study was lymphomatoid papulosis (type A and type C), followed by mycosis fungoides. Recognition of this large clinical and histological spectrum by dermatologists is important because diagnosis is often established by biopsy of skin lesions, even in secondary cutaneous cases. Moreover, the clinicopathological correlation is of utmost importance for the final diagnosis of those pathologies.

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Hypopigmented Mycosis Fungoides

Ranawaka¹

2020

Atlas of Dermatoses in Pigmented Skin

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Micosis fungoide. Experiencia en un hospital pediátrico

Cited by 9 publications

References 18 publications

Hypopigmented Mycosis Fungoides: Loss of Pigmentation Reflects Antitumor Immune Response in Young Patients

Hypopigmented Mycosis Fungoides: Loss of Pigmentation Reflects Antitumor Immune Response in Young Patients

Pediatric Cutaneous Hematologic Disorders: Cutaneous Lymphoma and Leukemia Cutis—Experience of a Tertiary-Care Pediatric Institution and Review of the Literature

Hypopigmented Mycosis Fungoides

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