Miconazole lacquer compared with gel in treatment of denture stomatitis

Abstract

Parvinen T, Kokko J, Yli-Urpo A: Micotiazole lacquer cotnpared with gel in treattnetit of denture stotnatitis. Scand J Detit Res J994; J02: 361-6. © Munksgaard, 1994. An open, randomized, controlled study with two parallel treatment groups was done to evaluate the efficacy atid safety of a single application of a miconazole 55 mg/g denture lacquer applied once on the mucosal denture surface, as compared with those of a commercially available miconazole 2% gel applied four times daily for 2 wk, in the treatment of Ca«f//c/a-associated denture stomatitis. The efficacy variables were Ccttidida cultures on the Oricult plates taken from the palatal mucosa and the denture surface, erythema of the palatal mucosa, and smears for leukocyte migration into the palatal epithelium taken on entering the study and on days 3, 7, 14, 21, 28, and 35 after commencement of therapy. On entering the study, all patients had positive cultures of yeast in the samples from the palatal mucosa. Within the first 3 days, all gel patients and 88% of the lacquer patients had fewer than 10 colonies. The gel was statistically significantly more efficient than the lacquer on days 7 and 14. In the samples from the denture surface, all patients had more than 100 yeast colonies at inclusion and, on day 3, approximately 80% in both treatment groups had fewer than 10 colonies. From day 7 onward, the gel was statistically significantly more elficient than the lacquer. The reddening of the palatal mucosa was not statistically significantly different in the treatment groups at any of the examinations, but smears for the determination of leukocyte migration indicated that the gel was statistically significantly more efficient than the lacquer on day 7. One patient in the gel group complained of gastrointestinal disturbance and stopped the treatment. On the basis of these results, it can be concluded that a single application of the miconazole denture lacquer is safe and creates an immediate antimycotic effect, A repeated application of the lacquer is, however, needed to achieve a prolonged effect.

Interventions for the Management of Denture Stomatitis: A Systematic Review and Meta‐Analysis

“…To compare different preparations of miconazole (gel vs varnish or lacquer) in the mycological assessment, fixed‐effects meta‐analysis was performed with data provided in two studies . There was no difference in use of miconazole as gel versus varnish or lacquer (RR = 1.56, 95% CI = 0.81–2.99) and no heterogeneity ( P = .27; I 2 = 19%).…”

Antifungal activity, biofilm-controlling effect, and biocompatibility of poly(N-vinyl-2-pyrrolidinone)-grafted denture materials

“…Two widely used antifungal agents, miconazole and chlorhexidine digluconate (CD) [56–59], were used as model drugs. To establish the binding capacity of the model drugs onto each of the PNVP-grafted denture materials, sample discs were individually immersed in either 5 wt% miconazole ethanol solution or 5 wt% CD aqueous solution at ambient temperature overnight.…”

Sustained Release of a Novel Anti-Quorum-Sensing Agent against Oral Fungal Biofilms

“…Topical antifungals are usually the drug of choice for uncomplicated, localized candidiasis (30,31); these include oral gels, lozenges, or varnishes applied to treat denture stomatitis (32,33). The drugs amphotericin B, clotrimazole, flucytosine, miconazole, nistatin, itraconazole, and ketoconazole have been the mainstream antifungal regime therapies for many years.…”