Miconazole and nystatin used as topical antifungal drugs interact equally strongly with warfarin

Kovač, Mirjana; Mitić, Gorana; Kovac, Z.

doi:10.1111/j.1365-2710.2011.01246.x

Cited by 26 publications

(14 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Protocols for oral hygienic management that have been reported until recently are mainly for use of gauze soaked with physiological saline solution,13 hydrogen peroxide, chlorohexidine, betadine, and nystatin in order to wipe off teeth or soft tissue in the mouth or to perform toothbrushing 26-31. Hydrogen peroxide is not recommended because it can be a stimulus to oral mucosa when it is not properly diluted 6,26.…”

Section: Discussionmentioning

confidence: 99%

Effect of an Oral Hygienic Care Program for Stroke Patients in the Intensive Care Unit

et al. 2014

View full text Add to dashboard Cite

PurposeThe effects of an oral hygienic care program (OHCP) have been reported in several diseases. However, no study exists investigating the influence of an OHCP on stroke patients or patients in the intensive care unit (ICU) has been reported, thus we sought to investigate the potential effect of an OHCP.Materials and MethodsFifty-six consecutive stroke patients who were admitted to the ICU were randomly assigned to two groups: the intervention (29 patients) and control groups (27 patients). The OHCP included tooth brushing with an inter-dental brush and tongue cleaner and cleaning with chlorhexidine was administered to patients by one dentist once per day during admission in the ICU (mean, 2.2 weeks). The plague index, gingival index, clinical attachment loss, and colonization degree of candida albicans were assessed.ResultsAfter OHCP, the plaque index, gingival index, and colonization degree of candida albicans in saliva showed a significant decrease in the intervention group compared to those of the control group (p<0.05). However, no significant difference was observed in clinical attachment loss and the colonization degree of candida albicans on the tongue (p>0.05).ConclusionOur OHCP was effective in improving the oral hygienic status and periodontal health of stroke patients during their stay in the ICU. Therefore, we recommend administration of the OHCP for stroke patients during their stay in the ICU.

show abstract

Section: Discussionmentioning

confidence: 99%

Effect of an Oral Hygienic Care Program for Stroke Patients in the Intensive Care Unit

et al. 2014

View full text Add to dashboard Cite

show abstract

“…For nystatin, only one report of an interaction with warfarin has been identified. (Kovac et al, 2012).…”

Section: Warfarin Miconazole and Nystatin: Publication Evidencementioning

confidence: 99%

Nystatin and miconazole: pharmacological and clinical evidence regarding interactions with warfarin

Pemberton

2016

Oral Diseases

View full text Add to dashboard Cite

show abstract

“…Miconazole, for example, may interact with anticoagulants, phenytoin, terbinafine, antipsychotics, cyclosporin and some statins used to treat hypercholesterolaemia. Nystatin may cause a bitter taste, allergic reactions and adrenal insufficiency . Therefore, alternative antifungal agents are needed to deal with DS.…”

Section: Introductionmentioning

confidence: 99%

Ricinus communis treatment of denture stomatitis in institutionalised elderly

Pinelli

Montandon

Corbi

et al. 2013

J of Oral Rehabilitation

View full text Add to dashboard Cite

This study compared the effectiveness of Ricinus communis (RC) with Nystatin (NYS) and Miconazole (MIC) in the treatment of institutionalised elderly with denture stomatitis (DS). They (n = 30) were randomly distributed into three groups: MIC, NYS or RC. Clinical and mycological evaluations were performed prior to the use of the antifungal (baseline) and repeated after 15 and 30 days of treatment. The sample was clinically examined for oral mucosal conditions. Standard photographs were taken of the palate, and the oral candidiasis was classified (Newton's criteria). Mycological investigation was performed by swabbing the palatal mucosa, and Candida spp. were quantified by counting the number of colony-forming units (cfu mL⁻¹). The clinical and mycological data were analysed, respectively by Wilcoxon and Student's t-test (α = 0.05). Significant improvement in the clinical appearance of DS in the MIC and RC groups was observed between the 1st and 3rd collections (MIC - P = 0.018; RC - P = 0.011) as well as between the 2nd and 3rd collections (MIC - P = 0.018; RC - P = 0.011). Neither groups showed a statistically significant reduction in cfu mL⁻¹ at any time. Although none of the treatments decreased the cfu mL⁻¹, it was concluded that Ricinus communis can improve the clinical condition of denture stomatitis in institutionalised elderly patients, showing similar results to Miconazole.

show abstract

Miconazole and nystatin used as topical antifungal drugs interact equally strongly with warfarin

Cited by 26 publications

References 13 publications

Effect of an Oral Hygienic Care Program for Stroke Patients in the Intensive Care Unit

Effect of an Oral Hygienic Care Program for Stroke Patients in the Intensive Care Unit

Nystatin and miconazole: pharmacological and clinical evidence regarding interactions with warfarin

Ricinus communis treatment of denture stomatitis in institutionalised elderly

Contact Info

Product

Resources

About