2022
DOI: 10.1016/j.ejphar.2022.174990
|View full text |Cite
|
Sign up to set email alerts
|

Michael acceptor-dependent pro-oxidative intervention against angiogenesis by [6]-dehydroshogaol, a pungent constituent of ginger

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
3
0

Year Published

2023
2023
2024
2024

Publication Types

Select...
4

Relationship

0
4

Authors

Journals

citations
Cited by 4 publications
(6 citation statements)
references
References 48 publications
0
3
0
Order By: Relevance
“… [ 487 ] [ 377 ] [ 488 ] TrxR TrxR-interfering drug delivery system (based on RGD-PEG-PUSeSe-PEG-RGD self-assembling micelles)→TrxR→Cancer Se-methylselenocysteine (SMC)→TrxR→AD (NCT01497431, etc.) Butaselen (BS)→TrxR1→Hepatocellular carcinoma BBSKE (Ethaselen)→TrxR1→Cancer ACZ2→TrxR1→Gastric cancer Ethaselen→TrxR1→Lung cancer [ 360 ] [ 489 ] [ 490 ] [ 491 ] [ 492 ] [ 493 ] Michael receptor TrxR [ 6 ]-dehydroshogaol→TrxR→Cancer DVD-445 and its extended analogues→TrxR→Cancer [ 494 ] [ 495 ] Quinazoline derivatives TXNIP Quinazoline derivatives (D-2 & C-1)→TXNIP→Diabetes [ 496 ] Imidazole derivatives Trx1 PX-12 (1-methylpropyl 2-imidazolyl disulfide)→Trx1→Cancer [ 497 ] Benzopyrane derivatives Trx & TrxR SIMR1281→Trx & TrxR→Cancer [ 498 ] Other compounds and therapeutic methods Trx Ac-Cys-Pro-Cys-amide (thioredoxin-mimetic peptide)→Atherosclerosis Ascorbate & menadione→Trx→Cancer HSA-Trx→Trx→ND, PD, Cardiomyopathy PPa@GA/DSPE-PEG2K NPs→Trx→Cancer Au nanoclusters→...…”
Section: Therapeutic Potential Of Trx Proteins In Aging Diseasesmentioning
confidence: 99%
“… [ 487 ] [ 377 ] [ 488 ] TrxR TrxR-interfering drug delivery system (based on RGD-PEG-PUSeSe-PEG-RGD self-assembling micelles)→TrxR→Cancer Se-methylselenocysteine (SMC)→TrxR→AD (NCT01497431, etc.) Butaselen (BS)→TrxR1→Hepatocellular carcinoma BBSKE (Ethaselen)→TrxR1→Cancer ACZ2→TrxR1→Gastric cancer Ethaselen→TrxR1→Lung cancer [ 360 ] [ 489 ] [ 490 ] [ 491 ] [ 492 ] [ 493 ] Michael receptor TrxR [ 6 ]-dehydroshogaol→TrxR→Cancer DVD-445 and its extended analogues→TrxR→Cancer [ 494 ] [ 495 ] Quinazoline derivatives TXNIP Quinazoline derivatives (D-2 & C-1)→TXNIP→Diabetes [ 496 ] Imidazole derivatives Trx1 PX-12 (1-methylpropyl 2-imidazolyl disulfide)→Trx1→Cancer [ 497 ] Benzopyrane derivatives Trx & TrxR SIMR1281→Trx & TrxR→Cancer [ 498 ] Other compounds and therapeutic methods Trx Ac-Cys-Pro-Cys-amide (thioredoxin-mimetic peptide)→Atherosclerosis Ascorbate & menadione→Trx→Cancer HSA-Trx→Trx→ND, PD, Cardiomyopathy PPa@GA/DSPE-PEG2K NPs→Trx→Cancer Au nanoclusters→...…”
Section: Therapeutic Potential Of Trx Proteins In Aging Diseasesmentioning
confidence: 99%
“…An example of this is the increased pro-oxidative capacity or the 6-dehydroshogaol. Liu et al (2022) investigated the mechanism of action for reducing angiogenesis through the comparative analysis of 6-gingerol, 6-shogaol, and 6-dehydroshogaol (Liu et al, 2022).…”
Section: S Emi -Synthe Ti C Derivative Smentioning
confidence: 99%
“…Liu et al. ( 2022 ) investigated the mechanism of action for reducing angiogenesis through the comparative analysis of 6‐gingerol, 6‐shogaol, and 6‐dehydroshogaol (Liu et al., 2022 ). The study found a higher capacity of 6‐dehydroshogaol to inhibit the cellular migration and invasion of people's umbilical vein endothelial cells.…”
Section: Semi‐synthetic Derivativesmentioning
confidence: 99%
“…Weng et al showed that 6-shogaol inhibited the expression of MMP-2/-9 and urokinase-type fibrinogen activator (uPA) in Hep3B cells by suppressing NF-kB, MAPK, PI3k/Akt, and STAT3 activity, thereby blocking vascular regeneration [ 40 ]. In addition, studies have shown that 6-shogaol can effectively inhibit tumor angiogenesis, which is related to its own structure, Michael receptors, and the number of Michael receptors is correlated with their antiangiogenic activity [ 85 ].These studies suggest that 6-shogaol is a potent inhibitor of tumor angiogenesis.…”
Section: The Therapeutic Mechanism Of 6-shogaol On Cancermentioning
confidence: 99%