Michael acceptor-dependent pro-oxidative intervention against angiogenesis by [6]-dehydroshogaol, a pungent constituent of ginger

Li, Xuefeng; Wang, Yihua; Zheng, Yayuan; Duan, De-Chen; Dai, Fang; Zhou, Bo

doi:10.1016/j.ejphar.2022.174990

Cited by 4 publications

(6 citation statements)

References 48 publications

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“… [ 487 ] [ 377 ] [ 488 ] TrxR TrxR-interfering drug delivery system (based on RGD-PEG-PUSeSe-PEG-RGD self-assembling micelles)→TrxR→Cancer Se-methylselenocysteine (SMC)→TrxR→AD (NCT01497431, etc.) Butaselen (BS)→TrxR1→Hepatocellular carcinoma BBSKE (Ethaselen)→TrxR1→Cancer ACZ2→TrxR1→Gastric cancer Ethaselen→TrxR1→Lung cancer [ 360 ] [ 489 ] [ 490 ] [ 491 ] [ 492 ] [ 493 ] Michael receptor TrxR [ 6 ]-dehydroshogaol→TrxR→Cancer DVD-445 and its extended analogues→TrxR→Cancer [ 494 ] [ 495 ] Quinazoline derivatives TXNIP Quinazoline derivatives (D-2 & C-1)→TXNIP→Diabetes [ 496 ] Imidazole derivatives Trx1 PX-12 (1-methylpropyl 2-imidazolyl disulfide)→Trx1→Cancer [ 497 ] Benzopyrane derivatives Trx & TrxR SIMR1281→Trx & TrxR→Cancer [ 498 ] Other compounds and therapeutic methods Trx Ac-Cys-Pro-Cys-amide (thioredoxin-mimetic peptide)→Atherosclerosis Ascorbate & menadione→Trx→Cancer HSA-Trx→Trx→ND, PD, Cardiomyopathy PPa@GA/DSPE-PEG2K NPs→Trx→Cancer Au nanoclusters→...…”

Section: Therapeutic Potential Of Trx Proteins In Aging Diseasesmentioning

confidence: 99%

Thioredoxin (Trx): A redox target and modulator of cellular senescence and aging-related diseases

Yang,

Lin,

Huang

et al. 2024

Redox Biology

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Section: Therapeutic Potential Of Trx Proteins In Aging Diseasesmentioning

confidence: 99%

Thioredoxin (Trx): A redox target and modulator of cellular senescence and aging-related diseases

Yang,

Lin,

Huang

et al. 2024

Redox Biology

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“…An example of this is the increased pro-oxidative capacity or the 6-dehydroshogaol. Liu et al (2022) investigated the mechanism of action for reducing angiogenesis through the comparative analysis of 6-gingerol, 6-shogaol, and 6-dehydroshogaol (Liu et al, 2022).…”

Section: S Emi -Synthe Ti C Derivative Smentioning

confidence: 99%

“…Liu et al. ( 2022 ) investigated the mechanism of action for reducing angiogenesis through the comparative analysis of 6‐gingerol, 6‐shogaol, and 6‐dehydroshogaol (Liu et al., 2022 ). The study found a higher capacity of 6‐dehydroshogaol to inhibit the cellular migration and invasion of people's umbilical vein endothelial cells.…”

Section: Semi‐synthetic Derivativesmentioning

confidence: 99%

Review of the anticancer properties of 6‐shogaol: Mechanisms of action in cancer cells and future research opportunities

Figueroa‐González,

Quintas‐Granados,

Reyes‐Hernández

et al. 2024

Food Science & Nutrition

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Cancer is a major global health challenge that affects every nation and accounts for a large portion of the worldwide disease burden. Furthermore, cancer cases will rise significantly in the next few decades. The Food and Drug Administration has approved more than 600 drugs for treating diverse types of cancer. However, many conventional anticancer medications cause side effects, and drug resistance develops as the treatment proceeds with a concomitant impact on patients' quality of life. Thus, exploring natural products with antitumor properties and nontoxic action mechanisms is essential. Ginger (Zingiber officinale Roscoe) rhizome has a long history of use in traditional medicine, and it contains biologically active compounds, gingerols and shogaols. The main ginger shogaol is 6‐shogaol, whose concentration dramatically increases during the processing of ginger, primarily due to the heat‐induced conversion of 6‐gingerol. Some studies have demonstrated that 6‐shogaol possesses biological and pharmacological properties, such as antioxidant, anti‐inflammatory, and anticancer activities. The mechanism of action of 6‐shogaol as an anticancer drug includes induction of paraptosis, induction of apoptosis, increase in the production of reactive oxygen species, induction of autophagy, and the inhibition of AKT/mTOR signaling. Despite this knowledge, the mechanism of action of 6‐shogaol is not fully understood, and the scientific data on its therapeutic dose, safety, and toxicity are not entirely described. This review article examines the potential of 6‐shogaol as an anticancer drug, addressing the limitations of current medications; it covers 6‐shogaol's attributes, mechanism of action in cancer cells, and opportunities for future research.

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“…Weng et al showed that 6-shogaol inhibited the expression of MMP-2/-9 and urokinase-type fibrinogen activator (uPA) in Hep3B cells by suppressing NF-kB, MAPK, PI3k/Akt, and STAT3 activity, thereby blocking vascular regeneration [ 40 ]. In addition, studies have shown that 6-shogaol can effectively inhibit tumor angiogenesis, which is related to its own structure, Michael receptors, and the number of Michael receptors is correlated with their antiangiogenic activity [ 85 ].These studies suggest that 6-shogaol is a potent inhibitor of tumor angiogenesis.…”

Section: The Therapeutic Mechanism Of 6-shogaol On Cancermentioning

confidence: 99%

Anticancer perspective of 6-shogaol: anticancer properties, mechanism of action, synergism and delivery system

Jia,

Li,

Meng

et al. 2023

Chin Med

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Cancer is a malignant disease that has plagued human beings all the time, but the treatment effect of commonly used anticancer drugs in clinical practice is not ideal by reason of their drug tolerance and Strong adverse reactions to patients. Therefore, it is imperative to find effective and low-toxic anticancer drugs. Many research works have shown that natural products in Chinese herbal medicine have great anticancer potential, such as 6-shogaol, a monomer composition obtained from Chinese herbal ginger, which has been confirmed by numerous in vitro or vivo studies to be an excellent anti-cancer active substance. In addition, most notably, 6-shogaol has different selectivity for normal and cancer cells during treatment, which makes it valuable for further research and clinical development. Therefore, this review focus on the anti-cancer attributes, the mechanism and the regulation of related signaling pathways of 6-shogaol. In addition, its synergy with commonly used anticancer drugs, potential drug delivery systems and prospects for future research are discussed. This is the first review to comprehensively summarize the anti-cancer mechanism of 6-shogaol, hoping to provide a theoretical basis and guiding significance for future anti-cancer research and clinical development of 6-shogaol. Graphical Abstract

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Michael acceptor-dependent pro-oxidative intervention against angiogenesis by [6]-dehydroshogaol, a pungent constituent of ginger

Cited by 4 publications

References 48 publications

Thioredoxin (Trx): A redox target and modulator of cellular senescence and aging-related diseases

Thioredoxin (Trx): A redox target and modulator of cellular senescence and aging-related diseases

Review of the anticancer properties of 6‐shogaol: Mechanisms of action in cancer cells and future research opportunities

Anticancer perspective of 6-shogaol: anticancer properties, mechanism of action, synergism and delivery system

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