MicF : an antisense RNA gene involved in response of Escherichia coli to global stress factors 1 1Edited by D. Draper

Delihas, Nicholas; Forst, Steven

doi:10.1006/jmbi.2001.5029

Cited by 195 publications

(154 citation statements)

References 88 publications

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“…1c), whereas H-NS converts circular DNA substrates into compact, dumbbell-shaped structures . In agreement with an antagonistic function of these proteins, H-NS-mediated transcriptional repression is enhanced in mutants lacking HU, but alleviated when HU is overexpressed [Manna and Gowrishankar, 1994;Delihas and Forst, 2001]. A general connection between HU-induced architectural changes and gene regulation is further supported by numerous reports that link HU to promoter function, although the molecular details are frequently unknown [Wagner, 2000].…”

Section: Mechansims Of Nucleoid Organizationmentioning

confidence: 77%

The bacterial nucleoid: A highly organized and dynamic structure

Thanbichler

Wang

Shapiro

2005

J of Cellular Biochemistry

121

101

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Recent advances in bacterial cell biology have revealed unanticipated structural and functional complexity, reminiscent of eukaryotic cells. Particular progress has been made in understanding the structure, replication, and segregation of the bacterial chromosome. It emerged that multiple mechanisms cooperate to establish a dynamic assembly of supercoiled domains, which are stacked in consecutive order to adopt a defined higher-level organization. The position of genetic loci on the chromosome is thereby linearly correlated with their position in the cell. SMC complexes and histone-like proteins continuously remodel the nucleoid to reconcile chromatin compaction with DNA replication and gene regulation. Moreover, active transport processes ensure the efficient segregation of sister chromosomes and the faithful restoration of nucleoid organization while DNA replication and condensation are in progress.

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Section: Mechansims Of Nucleoid Organizationmentioning

confidence: 77%

The bacterial nucleoid: A highly organized and dynamic structure

Thanbichler

Wang

Shapiro

2005

J of Cellular Biochemistry

121

101

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“…Thus, there does not appear to be any mechanism for monitoring the relative expression of OmpC and OmpF and for ensuring that the appropriate ratio is achieved. It is possible that there is feedback into the porin osmoregulatory network from cellular components other than OmpC and OmpF, e.g., from other proteins that are controlled by EnvZ and OmpR or from regulatory RNAs such as MicF (13). However, from the point of view of porin osmoregulation this would be an internal feedback loop, and the control system would still be open loop.…”

Section: Discussionmentioning

confidence: 99%

Continuous Control in Bacterial Regulatory Circuits

2004

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We show that for two well-characterized regulatory circuits in Escherichia coli, Tn10 tetracycline resistance and porin osmoregulation, the transcriptional outputs in individual cells are graded functions of the applied stimuli. These systems are therefore examples of naturally occurring regulatory circuits that exhibit continuous control of transcription. Surprisingly, however, we find that porin osmoregulation is open loop; i.e., the porin expression level does not feed back into the regulatory circuit. This mode of control is particularly interesting for an organism such as E. coli, which proliferates in diverse environments, and raises important questions regarding the biologically relevant inputs and outputs for this system.

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“…The expression of many sRNA genes is growth phase dependent or stress related [3,7]. Their small size makes it difficult to detect by biochemical or genetic methods [6].…”

Section: Introductionmentioning

confidence: 99%

Esre: A novel essential non‐coding RNA in Escherichia coli

Chen¹,

Wang²,

Li³

et al. 2012

FEBS Letters

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Edited by Tamas DalmayKeywords: Escherichia coli sRNA Essential sRNA Esre yigP a b s t r a c t YigP gene (GeneID: 948915) locates between ubiquinone biosynthetic genes ubiE and ubiB in Escherichia coli. GeneBank annotates yigP as a putative protein-coding gene. In this study, we found a new essential sRNA gene, esre, locates within the region of yigP. The E. coli strain with inactive esre must rely on a complementary plasmid to survive. Moreover, RACE experiments showed esre encodes an RNA molecule of 252 nt. Further experiments revealed esre gene is immune to frame shift mutations and the function of esre depends mostly on the RNA secondary structure, which are typical traits of sRNA. Since it is difficult to predict the target of an essential sRNA, more research is needed to reveal the function and mechanism of esre.

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MicF : an antisense RNA gene involved in response of Escherichia coli to global stress factors 1 1Edited by D. Draper

Cited by 195 publications

References 88 publications

The bacterial nucleoid: A highly organized and dynamic structure

The bacterial nucleoid: A highly organized and dynamic structure

Continuous Control in Bacterial Regulatory Circuits

Esre: A novel essential non‐coding RNA in Escherichia coli

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