Micelles from self-assembled double-hydrophilic PHEMA-glycopolymer-diblock copolymers as multivalent scaffolds for lectin binding

Park, H.; Walta, Stefan; Rosencrantz, Ruben R.; Körner, A.; Schulte, C.; Elling, Lothar; Richtering, Walter; Böker, Alexander

doi:10.1039/c5py00797f

Cited by 30 publications

(24 citation statements)

References 62 publications

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“…22 On the other hand, glycomaterials also display interesting characteristics in many biological recognition events, such as cell-cell adhesion and development of new tissues, and thus have potential applications in targeted drug delivery, tissue engineering, and synthesis of biocompatible materials. 23,24 Micro-organisms exhibit preferential adhesion to specific substrates, and this characteristic is a plausible target in the design of new antimicrobial compounds. It was suggested that the phagocytic cells of certain nonopsonized Escherichia coli express type I fimbriae that recognize mannose.…”

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confidence: 99%

Increasing bacterial affinity and cytocompatibility with four-arm star glycopolymers and antimicrobial α-polylysine

Pranantyo

Zheng

et al. 2017

Polym. Chem.

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A series of four-arm star copolymers, incorporating glycopolymer and antimicrobial polypeptide domains, was developed in the design of forthcoming anti-infective agents. Mannose, glucose, and galactosebased glycopolymers with a variety of well-defined chain lengths were prepared via atom transfer radical polymerization, whereas linear α-polylysine was prepared via ring-opening polymerization of N-carboxyanhydride monomers. Copper-catalyzed azide-alkyne cycloaddition was employed for 'click' conjugation of the glycopolymer arms and the polypeptide chains. The glycopolymer-polypeptide conjugates were non-hemolytic and exhibited higher cytocompatibility than the linear α-polylysine. The conjugates with shorter chains of mannose-based glycopolymer arms showed an enhanced bactericidal efficacy against Gram-negative and Gram-positive bacteria, with a therapeutic selectivity half of that of the linear α-polylysine. The pendant mannose moieties of the conjugates increased microbial targeting due to their specific affinity for bacterial surfaces, and binding competition with free mannopyranoside was demonstrated. Therefore, the molecular combination of glycopolymers and polypeptides without loss of their respective activities provides an interesting concept in the design of antimicrobial agents to combat infectious disease.

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confidence: 99%

Increasing bacterial affinity and cytocompatibility with four-arm star glycopolymers and antimicrobial α-polylysine

Pranantyo

Zheng

et al. 2017

Polym. Chem.

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“…At higher concentration between 5 and 20 wt% large particles were observed via optical microscopy. Micelles from self‐assembled DHBCs including a glycopolymer block were presented by Böker and co‐workers . A DHBC, namely, poly(2‐hydroxyethyl methacrylate)‐ b ‐poly(2‐O‐( N ‐acetyl‐β‐ d ‐glucosamine)ethyl methacrylate), was formed via ATRP.…”

Section: Double Hydrophilic Block Copolymer Systems For Self‐assemblymentioning

confidence: 99%

Double Hydrophilic Block Copolymer Self‐Assembly in Aqueous Solution

Schmidt

2018

Macro Chemistry & Physics

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Self‐assembly of double hydrophilic block copolymers (DHBCs) in water is an emerging area of research. The self‐assembly process can be derived from aqueous two‐phase systems that are composed of hydrophilic homopolymers at elevated concentration. Consecutively, DHBCs form self‐assembled structures like micelles, vesicles, or particles at high concentrations in water and without the use of external triggers that would change solubility of individual blocks. Careful choice of the two hydrophilic blocks and design of the polymer structure allows formation of self‐assembled structures with high efficiency. The present contribution highlights recent research in the area of DHBC self‐assembly, including the polymer types employed and strategies for crosslinking of the self‐assembled structures. Moreover, an overview of aqueous multiphase systems and theoretical considerations of DHBC self‐assembly are presented, as well as an outlook regarding potential future applications in areas such as the biomedical field.

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“…In such a way, various examples of DHBC self-assembled structures were described, e.g. vesicles, 21,22 micelles [23][24][25] or particles. [26][27][28] In addition, mesophases of DHBCs in water were observed at high concentrations.…”

Section: Introductionmentioning

confidence: 99%

Poly(ethylene glycol) brush-b-poly(N-vinylpyrrolidone)-based double hydrophilic block copolymer particles crosslinked via crystalline α-cyclodextrin domains

Nakeeb

Kochovski

et al. 2019

RSC Adv.

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Micelles from self-assembled double-hydrophilic PHEMA-glycopolymer-diblock copolymers as multivalent scaffolds for lectin binding

Cited by 30 publications

References 62 publications

Increasing bacterial affinity and cytocompatibility with four-arm star glycopolymers and antimicrobial α-polylysine

Increasing bacterial affinity and cytocompatibility with four-arm star glycopolymers and antimicrobial α-polylysine

Double Hydrophilic Block Copolymer Self‐Assembly in Aqueous Solution

Poly(ethylene glycol) brush-b-poly(N-vinylpyrrolidone)-based double hydrophilic block copolymer particles crosslinked via crystalline α-cyclodextrin domains

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