Micelle co-assembly in surfactant/ionic liquid mixtures

Chen, Lang G.; Strassburg, Stephen; Bermudez, Harry

doi:10.1016/j.jcis.2016.05.020

Cited by 13 publications

(6 citation statements)

References 57 publications

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“…The formation of polymeric micelles is due to the association of molecules on reaching the threshold concentration and temperature. This is called critical micellization concentration and critical micellization temperature (Chen et al 2016a). Their size usually varies in between 10-100 nm which primarily depends on the property of surfactants from which they are prepared.…”

Section: Micellesmentioning

confidence: 99%

Current development of theragnostic nanoparticles for women’s cancer treatment

Kashyap,

Kumari,

Singh

et al. 2024

Biomed. Mater.

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In the biomedical industry, nanoparticles (NPs - exclusively small particles with size ranging from 1 – 100 nanometres) are recently employed as powerful tools due to their huge potential in sophisticated and enhanced cancer theragnostic (i.e. therapeutics and diagnostics). Cancer is a life-threatening disease caused by carcinogenic agents and mutation in cells, leading to uncontrolled cell growth and harming the body's normal functioning while affecting several factors like low levels of ROS, hyperactive antiapoptotic mRNA expression, reduced proapoptotic mRNA expression, damaged DNA repair, and so on. NPs are extensively used in early cancer diagnosis and are functionalized to target receptors overexpressing cancer cells for effective cancer treatment. This review focuses explicitly on how NPs alone and combined with imaging techniques and advanced treatment techniques have been researched against “women’s cancer” such as breast, ovarian, and cervical cancer which are substantially occurring in women. NPs, in combination with numerous imaging techniques (like PET, SPECT, MRI, etc.) have been widely explored for cancer imaging and understanding tumor characteristics. Moreover, NPs in combination with various advanced cancer therapeutics (like magnetic hyperthermia, pH responsiveness, photothermal therapy, etc.), have been stated to be more targeted and effective therapeutic strategies with negligible side effects. Furthermore, this review will further help to improve treatment outcomes and patient quality of life based on the theragnostic application-based studies of NPs in women’s cancer treatment.

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Section: Micellesmentioning

confidence: 99%

Current development of theragnostic nanoparticles for women’s cancer treatment

Kashyap,

Kumari,

Singh

et al. 2024

Biomed. Mater.

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“…We recently reported the synthesis and study of a series of inherently biodegradable oxime-functionalized ILs [26] proposed as a base for a green decontamination IL-surfactant system. Although it is a well-established fact that the properties of ILs can be tuned with surfactants [27][28][29], using nonconventional surfactants (e.g., gemini surfactants) calls for more broad and detailed studies [30,31]. The gemini surfactants consist of two hydrophilic head groups and two hydrophobic chains covalently connected through a spacer group [32][33][34].…”

Section: Introductionmentioning

confidence: 99%

“…Gemini surfactants have been studied to shed light on the effect of structural variation of surfactants on their binding ability with drugs, which, in turn, may also open new approaches for designing tunable drug carrier systems [35]. A mixed system of surfactant and ILs/SAILs with distinct morphology and physicochemical properties improves their performance in terms of cooperative combination [27][28][29][30][31]. The IL-surfactant interaction plays a crucial role for some applications in pharmaceutical and biomedical science, namely, in enhancing the permeability of drugs across biological membranes [36].…”

Section: Introductionmentioning

confidence: 99%

Mixed Oxime-Functionalized IL/16-s-16 Gemini Surfactants System: Physicochemical Study and Structural Transitions in the Presence of Promethazine as a Potential Chiral Pollutant

et al. 2022

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The increasing concern about chiral pharmaceutical pollutants is connected to environmental contamination causing both chronic and acute harmful effects on living organisms. The design and application of sustainable surfactants in the remediation of polluted sites require knowledge of partitioning between surfactants and potential pollutants. The interfacial and thermodynamic properties of two gemini surfactants, namely, alkanediyi-α,ω-bis(dimethylhexadecyl ammonium bromide) (16-s-16, where s = 10, 12), were studied in the presence of the inherently biodegradable oxime-functionalized ionic liquid (IL) 4-((hydroxyimino)methyl)-1-(2-(octylamino)-2-oxoethyl)pyridin-1-ium bromide (4-PyC8) in an aqueous solution using surface tension, conductivity, fluorescence, FTIR and 1H NMR spectroscopic techniques. The conductivity, surface tension and fluorescence measurements indicated that the presence of the IL 4-PyC8 resulted in decreasing CMC and facilitated the aggregation process. The various thermodynamic parameters, interfacial properties, aggregation number and Stern–Volmer constant were also evaluated. The IL 4-PyC8-gemini interactions were studied using DLS, FTIR and NMR spectroscopic techniques. The hydrodynamic diameter of the gemini aggregates in the presence of promethazine (PMZ) as a potential chiral pollutant and the IL 4-PyC8 underwent a transition when the drug was added, from large aggregates (270 nm) to small micelles, which supported the gemini:IL 4-PyC8:promethazine interaction. The structural transitions in the presence of promethazine may be used for designing systems that are responsive to changes in size and shape of the aggregates as an analytical signal for selective detection and binding pollutants.

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“…Their surfactant molecules can be aggregated either by cationic, anionic, zwitterionic or non-ionic groups [ 5 ]. In aqueous solution, the non-polar hydrocarbon chain “tail” can be arranged into the center of a ball like structure “head” to form a micelle, because they are hydrophobic or “water hating” ( Scheme 1 ) [ 6 , 7 ]. They can be formed from a fatty acid, a salt of a fatty acid (soap), phospholipids, or other similar molecules.…”

Section: Introductionmentioning

confidence: 99%

Micelles Structure Development as a Strategy to Improve Smart Cancer Therapy

Hanafy

El‐Kemary

Leporatti

2018

Cancers

207

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Micelles as colloidal suspension have attracted considerable attention due to their potential use for both cancer diagnosis and therapy. These structures have proven their ability to deliver poorly water-soluble anticancer drugs, improve drug stability, and have good penetration and site-specificity, leading to enhance therapeutic efficacy. Micelles are composed of hydrophobic and hydrophilic components assembled into nanosized spherical, ellipsoid, cylindrical, or unilamellar structures. For their simple formation, they are widely studied, either by using opposite polymers attachment consisting of two or more block copolymers, or by using fatty acid molecules that can modify themselves in a rounded shape. Recently, hybrid and responsive stimuli nanomicelles are formed either by integration with metal nanoparticles such as silver, gold, iron oxide nanoparticles inside micelles or by a combination of lipids and polymers into single composite. Herein, through this special issue, an updated overview of micelles development and their application for cancer therapy will be discussed.

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Micelle co-assembly in surfactant/ionic liquid mixtures

Cited by 13 publications

References 57 publications

Current development of theragnostic nanoparticles for women’s cancer treatment

Current development of theragnostic nanoparticles for women’s cancer treatment

Mixed Oxime-Functionalized IL/16-s-16 Gemini Surfactants System: Physicochemical Study and Structural Transitions in the Presence of Promethazine as a Potential Chiral Pollutant

Micelles Structure Development as a Strategy to Improve Smart Cancer Therapy

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