Micelle-based nanoparticles with stimuli-responsive properties for drug delivery

Abstract

Cancer treatment often causes adverse effects and toxicity, as chemotherapy drugs affect both cancerous and healthy cells. Scientists seek to target tumor cells specifically and minimize harm to normal cells. Smart nanoparticles (NPs) are a modern technique that can release drugs when triggered by internal or external stimuli, such as temperature, pH, ultrasound, etc. This review covers stimuli-responsive micelle-based nanoparticles (SRM-NPs), a promising drug delivery platform that can enhance drug efficacy and reduce toxicity. It discusses the recent developments and applications of SRM-NPs, their responsiveness to different stimuli, and their potential to overcome drug resistance and adaptive responses. It also addresses the challenges and issues related to their stability, reproducibility, biocompatibility, safety, and optimization. The study concludes that SRM-NPs have great potential for drug delivery, but more research and development are needed to improve their clinical utility.

Colloidal and Biological Characterization of Dual Drug-Loaded Smart Micellar Systems

“…In this context, the so-called "smart" copolymers have attracted interest as their physicochemical properties can be modulated in response to the modification of a specific external stimulus. In order to increase the efficiency of PMs as DDSs, pH-and thermo-sensitive copolymers are extensively studied as these stimuli can be easily modified to trigger the API release at specific conditions [5,11,12]. This modification, which can be physical or chemical in nature, is most often reversible.…”