Micellar Solubilization of Testosterone III: Dissolution Behavior of Testosterone in Aqueous Solutions of Selected Surfactants

The Influence of Water Content of Triglyceride Oils on the Solubility of Steroids

“…The X-ray diffraction pattern of the recrystallized estradiol was in accordance with the crystal structure of the hemihydrate. DSC of recrystallized testosterone showed two well-defined endothermic peaks at 125°C and 163°C in agreement with the literature (11). TGA of recrystallized testosterone exhibited a loss of weight of 5.9%, consistent with the expected loss of water from a monohydrate of testosterone.…”

“…The monohydrate form of testosterone produced by recrystallization in acetone was dried to the anhydrous state by heating to 80°C for 48 h in the presence of phosphorus pentoxide (10)(11). This process was carried out using both radiolabeled and non-radiolabeled testosterone monohydrate.…”

Crystallographic data for testosterone hydrate and anhydrate

“…In a previous study on the solution behavior of testosterone in aqueous media, conversion of the anhydrate form to a hydrate was reported (Thakkar & Hall, 1969). Since testosterone is a natural hormone and exists in an aqueous environment, characterization of this form is important.…”

Estimation of Intragastric Solubility of Drugs: In What Medium?

“…Miconazole is known to form polymorphs (25,26); the melting point of solid miconazole in SGF SLS at 2 h was not distinct (63Y81-C) whereas the melting point of the powder used in solubility studies was 95-C. Temporary formation of supersaturated solutions of carbamazepine (27) and testosterone (28) in presence of SLS has also been reported.…”