Micellar nanocontainers based on PAAm-b-PEO-b-PAAm triblock copolymers for poorly soluble drugs

Zheltonozhskaya, Tatyana; Partsevskaya, Sofia; Fedorchuk, Sergey; Klymchuk, D. O.; Gomza, Yu. P.; Permyakova, N. M.; Kunitskaya, L. R.

doi:10.1016/j.eurpolymj.2012.10.028

Cited by 15 publications

(5 citation statements)

References 32 publications

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“…This mechanism depends on the ratio of the mers in the copolymer composition. Previously, Zheltonozhskaya et al − ,, demonstrated the participation of the transmultimers of the amide groups of triblock copolymers in the formation of the hydrogen bond system between the poly(ethylene oxide) and PAAm segments (see Figure , structure f). The enhanced temperature-dependent response of wettability for P(OEGMA188- co -AAm) copolymers with a high mole fraction of hydrophilic AAm (see Figure a), not accompanied by any significant changes in coating thickness (see Figure ), suggests the formation at transition temperature T c of more hydrophobic structures realized by hydrogen bonding between ether oxygens of OEGMA188 and amide fragments of AAm (see Figure , structure f) where water molecules are caged.…”

Section: Results and Discussionmentioning

confidence: 97%

“…In turn, PAAm in water at room temperature (that is, above T c ) forms different hydrogen bond structures, − including free amide groups (Figure , structure c), cis-trans -multimers (Figure , structure d), and trans -multimers (Figure , structure e) of amide groups. However, the amount of cis-trans -associates as well as trans -associates of the amide groups in PAAm is significantly smaller than that of free amide groups.…”

Section: Results and Discussionmentioning

confidence: 99%

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Temperature- and pH-Responsive Schizophrenic Copolymer Brush Coatings with Enhanced Temperature Response in Pure Water

Shymborska

Stetsyshyn

Awsiuk

et al. 2023

ACS Appl. Mater. Interfaces

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Novel brush coatings were fabricated with glass surface-grafted chains copolymerized using surface-initiated atom transfer radical polymerization (SI-ATRP) from 2-(2-methoxyethoxy)ethyl methacrylate (OEGMA188) and acrylamide (AAm), taken in different proportions. P(OEGMA188-co-AAm) brushes with AAm mole fraction >44% (determined with XPS and TOF-SIMS spectroscopy) and nearly constant with the depth copolymer composition (TOF-SIMS profiling) exhibit unusual temperature-induced transformations: The contact angle of water droplets on P(OEGMA188-co-AAm) coatings increases by ∼45° with temperature, compared to 17–18° for POEGMA188 and PAAm. The thickness of coatings immersed in water and the morphology of coatings imaged in air show a temperature response for POEGMA188 (using reflectance spectroscopy and AFM, respectively), but this response is weak for P(OEGMA188-co-AAm) and absent for PAAm. This suggests mechanisms more complex than a simple transition between hydrated loose coils and hydrophobic collapsed chains. For POEGMA188, the hydrogen bonds between the ether oxygens of poly(ethylene glycol) and water hydrogens are formed below the transition temperature T c and disrupted above T c when polymer–polymer interactions are favored. Different hydrogen bond structures of PAAm include free amide groups, cis-trans-multimers, and trans-multimers of amide groups. Here, hydrogen bonds between free amide groups and water dominate at T < T c but structures favored at T > T c, such as cis-trans-multimers and trans-multimers of amide groups, can still be hydrated. The enhanced temperature-dependent response of wettability for P(OEGMA188-co-AAm) with a high mole fraction of AAm suggests the formation at T c of more hydrophobic structures, realized by hydrogen bonding between the ether oxygens of OEGMA188 and the amide fragments of AAm, where water molecules are caged. Furthermore, P(OEGMA188-co-AAm) coatings immersed in pH buffer solutions exhibit a ‘schizophrenic’ behavior in wettability, with transitions that mimic LCST and UCST for pH = 3, LCST for pH = 5 and 7, and any transition blocked for pH = 9.

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Section: Results and Discussionmentioning

confidence: 97%

Section: Results and Discussionmentioning

confidence: 99%

Temperature- and pH-Responsive Schizophrenic Copolymer Brush Coatings with Enhanced Temperature Response in Pure Water

Shymborska

Stetsyshyn

Awsiuk

et al. 2023

ACS Appl. Mater. Interfaces

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“…На основі триблок-кополімерів поліетиленоксиду і поліакриламіду та їхніх частково гідролізованих похідних розроблено міцелярні наноконтейнери для зв'язування і доставки протиракового препарату доксорубіцину [90][91][92].…”

Section: д г вишневський)unclassified

From Organics to Polymers

Kolendo

Savchenko

Vretik

et al. 2017

Bull. T. Shevchenko Nat. Univ. Kyiv. Chem.

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Polymers, composites, their components and complexes for application in information tecnologies and biotechnology as well as for medicine and solar energy transfer have been obtained. In particular, new high-resolution photochromic polymer materials with a significant nonlinear optical effect of the third order have been developed. They are perspective for the creation of high-speed optical switches in optical recording and information storage. A new way of recording information based on the generation of the second harmonic with new photochromic polymers has been found. The perspectivity of alken-functionalised poly(phenyl/naphthylmethacrylates) as basic compounds for polarization-sensitive polymeric media was prooved.The chemical modification of polymers by benzenesulfonamide derivatives for biostabilization of plastic masses and providing hydrophilic properties for their surface was carried out. A fundamentally new approach is developed in which processes of energy transfer of excited states in polymer macromolecule to the photostabilaser are used for effective stabilization of polymer materials. Thermostabilized samples of polystyrene with covalently bonded of imidophenylmethacrylates have been developed. The branched copolymers are highly efficient matrices for the synthesis of stable gold, silver, CdS and Au / CdS nanoparticles and copolymers that can be used as nanovectors for the target delivery of highly toxic antitumor drugs. New effective preparations for desinfaсtion of fish nurseries, dressing and hygienic materials, linen and clothes have been developed.

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“…Such polymers have enormous technological applicability and they find use in drug delivery systems, nano-templating, DNA transfer, paints, cosmetics, personal care products, water treatment, enhanced oil recovery and more [3][4][5][6][7]. Generally, amphiphilic block copolymers form core-corona type micelles in aqueous solution with a core made of hydrophobic blocks and shell from the hydrated hydrophilic blocks [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Self-assembly of multi-responsive poly(N-isopropylacrylamide)-b-poly(N,N-dimethylaminopropylacrylamide) in aqueous media

Khimani

Yusa

Nagae

et al. 2015

European Polymer Journal

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Micellar nanocontainers based on PAAm-b-PEO-b-PAAm triblock copolymers for poorly soluble drugs

Cited by 15 publications

References 32 publications

Temperature- and pH-Responsive Schizophrenic Copolymer Brush Coatings with Enhanced Temperature Response in Pure Water

Temperature- and pH-Responsive Schizophrenic Copolymer Brush Coatings with Enhanced Temperature Response in Pure Water

From Organics to Polymers

Self-assembly of multi-responsive poly(N-isopropylacrylamide)-b-poly(N,N-dimethylaminopropylacrylamide) in aqueous media

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