Micellar electrokinetic capillary chromatography analysis of diuretics in pharmaceutical formulations

Luis, M Luz; Corujedo, Sara Junco; Blanco, Domingo; Fraga, Jose María; Jiménez, Ana I.; Jiménez, Francisco Jiménez; Arias, J. J.

doi:10.1016/s0039-9140(02)00018-8

Cited by 29 publications

(10 citation statements)

References 20 publications

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“…Several analytical methods have been published for the determination of Hydrchlorothiazide in tablet susingflowinjection 6 , spectrophotometric [7][8][9] , densitometric 10 , HPLC [7][8][9][10][11][12][13] , electrophoretic [14][15] andpolarographic 16 methods. The simultaneous determination of EPR and HCTZ was studied by HPTLC 17 , HPLC and derivative spectrophotmetry 18 .…”

Section: Figure 2 Chemical Structures Of Hydrchlorothiazide (Hctz)mentioning

confidence: 99%

Development and Validation of a New Stability-Indicating Liquid Chromatographic Method for the Simultaneous Determination of Eprosartan and Hydrchlorothiazide in Tablets

2014

Chem Sci Trans

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A validated stability-indicating high-performance liquid chromatographic method has been developed for the simultaneous determination of Eprosartan and hydrochlorothiazide in tablet dosage forms. Chromatographic separation was performed on HPLC system of waters Model 2997 using X Bridge Shield RP18 (150 x 3.0 mm i.d., 3.5 µm particle size) column with a mixture of 0.1% formic acid and acetonitrile as mobile phase with a flow rate of 0.8 mL/min (gradient mode) with UV detection at 235 nm. The combinationof drugs was subjected to stress conditions such as acidic, alkaline, oxidation photolytic and thermal degradations and the method was validated as per ICH guidelines.

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Section: Figure 2 Chemical Structures Of Hydrchlorothiazide (Hctz)mentioning

confidence: 99%

Development and Validation of a New Stability-Indicating Liquid Chromatographic Method for the Simultaneous Determination of Eprosartan and Hydrchlorothiazide in Tablets

2014

Chem Sci Trans

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“…Several methods have been reported for the assay of TRI. In pharmaceutical preparations, it has been assayed using micellar electrokinetic chromatography [2], chemometric spectrophotometry [3], micellar liquid chromatography [4], spectrophotometry [5], fluorimetry [6], chemometric fluorimetry [7], potentiometry [8], adsorptive stripping voltammetry [9], thin-layer chromatography (TLC) [10], and capillary electrophoresis [11]. Xipamide (XIP) is a sulfonamide diuretic drug ( Fig.…”

Section: Introductionmentioning

confidence: 99%

Stability-indicating HPLC-DAD method development, validation, and stress degradation studies for triamterene and xipamide in their combined tablet dosage form

El-Kimary¹

2016

Acta Chromatographica

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“…1, 2009 that permit the determination of this diuretic drug in pharmaceuticals and biological samples (milk, urine, plasma and serum). 11,12 These methods include spectrophotometry, [13][14][15][16][17][18] variable-angle scanning fluorescence spectrometry, 19 spectrofluorimetry, 20,21 diffuse reflectance spectroscopy, 22 potentiometry, 23 voltammetry, 24 chromatography, [25][26][27][28][29][30][31][32][33][34][35] capillary electrophoresis, [36][37][38][39] and flow-injection analysis. 40,41 However, many of these methods are often time-consuming, technically demanding and require the use of costly, highly specialized instruments.…”

Section: Introductionmentioning

confidence: 99%

Potentiometric sensor for furosemide determination in pharmaceuticals, urine, blood serum and bovine milk

Santini¹,

Pezza²,

Sequinel³

et al. 2009

J. Braz. Chem. Soc.

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A construção, avaliação e aplicação analítica de um sensor potenciométrico do tipo PtHgHg 2 (Fur) 2 Grafite, onde Fur significa íon 4-cloro-N-furfuril-5-sulfamoil-antranilato, são descritas. O eletrodo responde a Fur com sensibilidade de (−58,4 ± 0,9) mV década -1 no intervalo de 5,0 × 10 -7 -1,0 × 10 -2 mol L -1 , a pH 7,0-9,0 e com um limite de detecção de 3,8 × 10 -7 mol L -1 . O eletrodo é facilmente construído e de baixo custo, apresenta um rápido tempo de resposta (10-20 s) e pode ser usado por um período de 6 meses sem qualquer variação considerável nas suas características de desempenho. O eletrodo proposto mostrou boa seletividade na presença de várias substâncias, bem como na presença de alguns carboxilatos e ânions inorgânicos. O eletrodo foi aplicado com sucesso na determinação de furosemida em medicamentos, urina, soro sanguíneo e amostras comerciais de leite bovino.The construction, evaluation and analytical application of a potentiometric sensor, namely, PtHgHg 2 (Fur) 2 Graphite, where Fur stands for 4-chloro-N-furfuryl-5-sulphamoyl-anthranilate ion, are described. This electrode has a linear dynamic range between 5.0 × 10 -7 -1.0 × 10 -2 mol L -1 with a near-Nernstian slope of (-58.4± 0.9) mV decade -1 and a detection limit of 3.8 × 10 -7 mol L -1 . The potentiometric response is independent of the pH of the solution in the pH range 7.0-9.0. The electrode shows easy construction, low-cost, fast response time (within 10-20 s) and can be used for a period of 6 months without significant change in its performance characteristics. The proposed sensor displayed good selectivities over a variety of other anions (carboxylates and inorganic anions). Application of this potentiometric sensor for the furosemide determination in pharmaceuticals, urine, blood serum and commercial milk samples is reported.Keywords: 4-cloro-N-furfuryl-5-sulphamoylanthranilate-sensitive electrode, potentiometry, pharmaceuticals, urine, human blood serum, bovine milk IntroductionFurosemide or frusemide (HFur, 4-chloro-N-furfuryl-5-sulphamoyl-anthranilic acid) is formally a sulfonamide, an antibacterial agent (Figure 1). However, the intense and fast dieresis produced by this drug has extended its application as a powerful acidic diuretic for diverse treatments in humans and veterinary medicine. Furosemide is often classified as a loop diuretic due to its predominant action in the nephron, where the drug interferes with the tubular re-absorption of sodium on Henle's loop. 1 The renal excretion of ions is not limited to sodium and chloride, but it may also influence potassium, magnesium, calcium and, to a lesser extent, hydrogen carbonate ions. 2 In the clinical practice, the effects of furosemide are applied in the treatment of edema associated with pulmonary, cardiac, hepatic and renal disease, and of hypertension accompanied by fluid retention or impaired renal failure. 3-7 A marked diuresis is also associated to loss of weight, a side effect that has been incorrectly abused in the sport practice to achieve acute weight ...

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Micellar electrokinetic capillary chromatography analysis of diuretics in pharmaceutical formulations

Cited by 29 publications

References 20 publications

Development and Validation of a New Stability-Indicating Liquid Chromatographic Method for the Simultaneous Determination of Eprosartan and Hydrchlorothiazide in Tablets

Development and Validation of a New Stability-Indicating Liquid Chromatographic Method for the Simultaneous Determination of Eprosartan and Hydrchlorothiazide in Tablets

Stability-indicating HPLC-DAD method development, validation, and stress degradation studies for triamterene and xipamide in their combined tablet dosage form

Potentiometric sensor for furosemide determination in pharmaceuticals, urine, blood serum and bovine milk

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